Rab12 (RAB12, member RAS oncogene family) - Rat Genome Database

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Gene: Rab12 (RAB12, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab12
Name: RAB12, member RAS oncogene family
RGD ID: 3527
Description: Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including Golgi vesicle fusion to target membrane; endocytic recycling; and secretion by cell. Predicted to act upstream of or within cellular response to type II interferon. Located in secretory granule. Orthologous to human RAB12 (RAB12, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC680714; LOC100362985; LOC102551479; LOC680714; ras-related protein Rab-12; ras-related protein Rab-12-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,927,119 - 113,953,722 (-)NCBIGRCr8
mRatBN7.29106,480,301 - 106,506,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9106,480,301 - 106,506,910 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9114,869,871 - 114,895,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,992,575 - 120,018,922 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09118,335,731 - 118,360,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09114,683,985 - 114,709,613 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,684,039 - 114,709,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09114,153,790 - 114,211,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,369,269 - 79,370,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19105,834,937 - 105,854,349 (-)NCBI
Celera9103,654,511 - 103,681,028 (-)NCBICelera
Cytogenetic Map9q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
GDP binding  (ISO,ISS)
GTP binding  (IEA,TAS)
GTPase activity  (IBA,IEA)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of rab12 as a secretory granule-associated small GTP-binding protein in atrial myocytes. Iida H, etal., Circ Res 1996 Feb;78(2):343-7.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:19144319   PMID:20937701   PMID:21718402   PMID:23357852   PMID:26740112  


Genomics

Comparative Map Data
Rab12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,927,119 - 113,953,722 (-)NCBIGRCr8
mRatBN7.29106,480,301 - 106,506,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9106,480,301 - 106,506,910 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9114,869,871 - 114,895,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,992,575 - 120,018,922 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09118,335,731 - 118,360,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09114,683,985 - 114,709,613 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,684,039 - 114,709,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09114,153,790 - 114,211,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,369,269 - 79,370,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19105,834,937 - 105,854,349 (-)NCBI
Celera9103,654,511 - 103,681,028 (-)NCBICelera
Cytogenetic Map9q37NCBI
RAB12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38188,609,437 - 8,639,383 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl188,609,437 - 8,639,383 (+)EnsemblGRCh38hg38GRCh38
GRCh37188,609,435 - 8,639,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36188,599,443 - 8,629,380 (+)NCBINCBI36Build 36hg18NCBI36
Celera188,493,793 - 8,523,729 (+)NCBICelera
Cytogenetic Map18p11.22NCBI
HuRef188,573,832 - 8,603,702 (+)NCBIHuRef
CHM1_1188,609,630 - 8,639,561 (+)NCBICHM1_1
T2T-CHM13v2.0188,772,604 - 8,802,430 (+)NCBIT2T-CHM13v2.0
Rab12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,801,507 - 66,826,712 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,801,507 - 66,826,724 (-)EnsemblGRCm39 Ensembl
GRCm381766,494,512 - 66,519,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1766,494,512 - 66,519,729 (-)EnsemblGRCm38mm10GRCm38
MGSCv371766,843,852 - 66,869,010 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361766,399,903 - 66,403,053 (-)NCBIMGSCv36mm8
Celera1770,794,697 - 70,819,774 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1737.88NCBI
Rab12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554023,103,708 - 3,110,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554023,102,709 - 3,109,701 (-)NCBIChiLan1.0ChiLan1.0
RAB12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21729,812,893 - 29,842,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11815,505,488 - 15,535,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0185,646,023 - 5,675,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1187,972,938 - 8,002,396 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl187,972,938 - 8,027,500 (-)Ensemblpanpan1.1panPan2
RAB12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1774,752,697 - 74,791,872 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha774,156,331 - 74,183,601 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0774,816,718 - 74,843,988 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl774,816,718 - 74,843,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1774,519,047 - 74,546,312 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0774,537,542 - 74,564,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0774,843,119 - 74,870,370 (+)NCBIUU_Cfam_GSD_1.0
Rab12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494471,800,038 - 71,822,597 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366702,315,442 - 2,338,509 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366702,315,930 - 2,338,489 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl699,216,228 - 99,244,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1699,216,225 - 99,244,627 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAB12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11867,572,529 - 67,600,646 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1867,572,519 - 67,601,428 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605042,507,756 - 42,535,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477017,635,901 - 17,653,919 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477017,636,031 - 17,654,863 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab12
146 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000026177
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

Markers in Region
RH129245  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera9103,654,577 - 103,654,786UniSTS
Cytogenetic Map9q37UniSTS
RH138031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29106,505,613 - 106,505,837 (+)MAPPERmRatBN7.2
Rnor_6.09114,708,428 - 114,708,651NCBIRnor6.0
Rnor_5.09114,210,034 - 114,210,257UniSTSRnor5.0
RGSC_v3.49105,643,888 - 105,644,111UniSTSRGSC3.4
Celera9103,679,846 - 103,680,069UniSTS
Cytogenetic Map9q37UniSTS
RH129304  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera9103,654,596 - 103,654,814UniSTS
Cytogenetic Map9q37UniSTS
RH135112  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera9103,655,190 - 103,655,384UniSTS
Cytogenetic Map9q37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 43 22 6 19 6 8 11 74 34 38 11 8
Low 2 35 35 35 1 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026177   ⟹   ENSRNOP00000059602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9106,482,503 - 106,506,799 (-)Ensembl
Rnor_6.0 Ensembl9114,684,039 - 114,709,546 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098588   ⟹   ENSRNOP00000076702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9106,480,301 - 106,506,910 (-)Ensembl
RefSeq Acc Id: NM_013017   ⟹   NP_037149
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89113,927,119 - 113,953,616 (-)NCBI
mRatBN7.29106,480,301 - 106,506,799 (-)NCBI
Rnor_6.09114,683,985 - 114,709,613 (-)NCBI
Rnor_5.09114,153,790 - 114,211,219 (-)NCBI
Celera9103,654,511 - 103,681,028 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266705   ⟹   XP_063122775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89113,938,261 - 113,953,722 (-)NCBI
RefSeq Acc Id: XR_005488852
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89113,928,356 - 113,953,719 (-)NCBI
mRatBN7.29106,481,279 - 106,506,895 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037149 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122775 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41992 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059602.4
  ENSRNOP00000076702
  ENSRNOP00000076702.1
GenBank Protein P35284 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037149   ⟸   NM_013017
- UniProtKB: P35284 (UniProtKB/Swiss-Prot),   A6KF57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059602   ⟸   ENSRNOT00000026177
RefSeq Acc Id: ENSRNOP00000076702   ⟸   ENSRNOT00000098588
RefSeq Acc Id: XP_063122775   ⟸   XM_063266705
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35284-F1-model_v2 AlphaFold P35284 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3527 AgrOrtholog
BioCyc Gene G2FUF-26407 BioCyc
Ensembl Genes ENSRNOG00000019295 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026177.8 UniProtKB/TrEMBL
  ENSRNOT00000098588 ENTREZGENE
  ENSRNOT00000098588.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25530 UniProtKB/Swiss-Prot
NCBI Gene 25530 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab12 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019295 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208980
UniProt A0A8I5Y4W3_RAT UniProtKB/TrEMBL
  A6KF57 ENTREZGENE, UniProtKB/TrEMBL
  D4A376_RAT UniProtKB/TrEMBL
  P35284 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rab12  RAB12, member RAS oncogene family  LOC102551479  ras-related protein Rab-12-like  Data merged from RGD:7652518 737654 PROVISIONAL
2015-07-29 LOC102551479  ras-related protein Rab-12-like  LOC680714  hypothetical protein LOC680714  Data merged from RGD:1588252 737654 PROVISIONAL
2013-12-18 LOC102551479  ras-related protein Rab-12-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-12 Rab12  RAB12, member RAS oncogene family  LOC100362985  ras-related protein Rab-12-like  Data merged from RGD:2323709 737654 PROVISIONAL
2010-05-06 LOC100362985  ras-related protein Rab-12-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC680714  hypothetical protein LOC680714      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Rab12  RAB12, member RAS oncogene family      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to secretory granules in atrial myocytes 734515