MIR2115 (microRNA 2115) - Rat Genome Database

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Gene: MIR2115 (microRNA 2115) Homo sapiens
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Symbol: MIR2115
Name: microRNA 2115
RGD ID: 3497327
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,316,360 - 48,316,459 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,316,360 - 48,316,459 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,357,850 - 48,357,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef348,411,877 - 48,411,976 (-)NCBIHuRef
CHM1_1348,310,155 - 48,310,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:19390579   PMID:20224791  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:46166
Count of gene targets:16447
Count of transcripts:35012
Interacting mature miRNAs:hsa-miR-2115-3p, hsa-miR-2115-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 7 3 16 2 23 2 52 8 57 9 21 21 2 12
Below cutoff 15 19 13 1 6 34 18 105 2 17 12 1 8 28

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000516657
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,316,360 - 48,316,459 (-)Ensembl
RefSeq Acc Id: NR_031749
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,316,360 - 48,316,459 (-)NCBI
GRCh37348,357,850 - 48,357,949 (-)RGD
HuRef348,411,877 - 48,411,976 (-)ENTREZGENE
CHM1_1348,310,155 - 48,310,254 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR2115 COSMIC
Ensembl Genes ENSG00000252466 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000516657 ENTREZGENE
GTEx ENSG00000252466 GTEx
HGNC ID HGNC:37309 ENTREZGENE
Human Proteome Map MIR2115 Human Proteome Map
miRBase MI0010634 ENTREZGENE
NCBI Gene 100313840 ENTREZGENE
PharmGKB PA165697571 PharmGKB
RNAcentral URS000075A638 RNACentral
  URS000075D549 RNACentral
  URS000075F01D RNACentral