MIR2116 (microRNA 2116) - Rat Genome Database

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Gene: MIR2116 (microRNA 2116) Homo sapiens
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Symbol: MIR2116
Name: microRNA 2116
RGD ID: 3497322
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-2116
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1559,171,183 - 59,171,262 (-)EnsemblGRCh38hg38GRCh38
GRCh381559,171,183 - 59,171,262 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371559,463,382 - 59,463,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1536,351,331 - 36,351,410 (-)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1536,285,588 - 36,285,667 (-)NCBIHuRef
CHM1_11559,581,351 - 59,581,430 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:19390579   PMID:21037258   PMID:30939038   PMID:31678272   PMID:33073675  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PLA2G4Fhsa-miR-2116-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:32611
Count of gene targets:13967
Count of transcripts:26690
Interacting mature miRNAs:hsa-miR-2116-3p, hsa-miR-2116-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 1 57 1 2 3 8
Low 154 55 144 104 373 106 287 51 113 115 224 258 9 24 68 4
Below cutoff 43 27 15 6 24 6 62 33 26 13 11 29 21 36

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000517221
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1559,171,183 - 59,171,262 (-)Ensembl
RefSeq Acc Id: NR_031750
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,171,183 - 59,171,262 (-)NCBI
GRCh371559,463,382 - 59,463,461 (-)RGD
Celera1536,351,331 - 36,351,410 (-)RGD
HuRef1536,285,588 - 36,285,667 (-)ENTREZGENE
CHM1_11559,581,351 - 59,581,430 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1 copy number loss See cases [RCV000051621] Chr15:50864913..59646577 [GRCh38]
Chr15:51157110..59938776 [GRCh37]
Chr15:48944402..57726068 [NCBI36]
Chr15:15q21.2-22.2
pathogenic
GRCh38/hg38 15q21.3-22.2(chr15:57567950-63019415)x1 copy number loss See cases [RCV000051622] Chr15:57567950..63019415 [GRCh38]
Chr15:57860148..63311614 [GRCh37]
Chr15:55647440..61098667 [NCBI36]
Chr15:15q21.3-22.2
pathogenic
GRCh38/hg38 15q21.3-22.2(chr15:57456076-61907285)x1 copy number loss See cases [RCV000050884] Chr15:57456076..61907285 [GRCh38]
Chr15:57748274..62199484 [GRCh37]
Chr15:55535566..59986776 [NCBI36]
Chr15:15q21.3-22.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR2116 COSMIC
Ensembl Genes ENSG00000253030 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000517221 ENTREZGENE
GTEx ENSG00000253030 GTEx
HGNC ID HGNC:37310 ENTREZGENE
Human Proteome Map MIR2116 Human Proteome Map
miRBase MI0010635 ENTREZGENE
NCBI Gene 100313886 ENTREZGENE
PharmGKB PA165479174 PharmGKB
RNAcentral URS00000BA274 RNACentral
  URS00005237AB RNACentral
  URS000075B884 RNACentral