MIR2277 (microRNA 2277) - Rat Genome Database
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Gene: MIR2277 (microRNA 2277) Homo sapiens
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Symbol: MIR2277
Name: microRNA 2277
RGD ID: 3497321
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-2277
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl593,620,696 - 93,620,788 (-)EnsemblGRCh38hg38GRCh38
GRCh38593,620,696 - 93,620,788 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37592,956,402 - 92,956,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera588,815,798 - 88,815,890 (-)NCBI
Cytogenetic Map5q15NCBI
HuRef588,129,353 - 88,129,445 (-)NCBIHuRef
CHM1_1592,389,111 - 92,389,203 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:19508715   PMID:20224791   PMID:21037258  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:28698
Count of gene targets:11866
Count of transcripts:24094
Interacting mature miRNAs:hsa-miR-2277-3p, hsa-miR-2277-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000515916
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl593,620,696 - 93,620,788 (-)Ensembl
RefSeq Acc Id: NR_031754
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38593,620,696 - 93,620,788 (-)NCBI
GRCh37592,956,402 - 92,956,494 (-)RGD
Celera588,815,798 - 88,815,890 (-)RGD
HuRef588,129,353 - 88,129,445 (-)ENTREZGENE
CHM1_1592,389,111 - 92,389,203 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q14.3-21.1(chr5:85966055-101335711)x1 copy number loss See cases [RCV000135748] Chr5:85966055..101335711 [GRCh38]
Chr5:85261873..100671415 [GRCh37]
Chr5:85297629..100699314 [NCBI36]
Chr5:5q14.3-21.1
pathogenic
GRCh38/hg38 5q14.3-23.3(chr5:90374606-128076423)x1 copy number loss See cases [RCV000139893] Chr5:90374606..128076423 [GRCh38]
Chr5:89670423..127412115 [GRCh37]
Chr5:89706179..127440014 [NCBI36]
Chr5:5q14.3-23.3
pathogenic
GRCh38/hg38 5q14.3-22.1(chr5:84603580-111435081)x1 copy number loss See cases [RCV000139656] Chr5:84603580..111435081 [GRCh38]
Chr5:83899398..110770779 [GRCh37]
Chr5:83935154..110798678 [NCBI36]
Chr5:5q14.3-22.1
pathogenic
GRCh38/hg38 5q14.3-23.1(chr5:92899734-119614119)x1 copy number loss See cases [RCV000141252] Chr5:92899734..119614119 [GRCh38]
Chr5:92235441..118949814 [GRCh37]
Chr5:92261197..118977713 [NCBI36]
Chr5:5q14.3-23.1
pathogenic
GRCh38/hg38 5q14.3-15(chr5:92031269-93947338)x1 copy number loss See cases [RCV000140706] Chr5:92031269..93947338 [GRCh38]
Chr5:91327086..93283043 [GRCh37]
Chr5:91362842..93308799 [NCBI36]
Chr5:5q14.3-15
likely pathogenic|uncertain significance
GRCh38/hg38 5q15-22.2(chr5:93193104-113287795)x1 copy number loss See cases [RCV000143249] Chr5:93193104..113287795 [GRCh38]
Chr5:92528810..112623492 [GRCh37]
Chr5:92554566..112651391 [NCBI36]
Chr5:5q15-22.2
pathogenic
GRCh38/hg38 5q14.3-31.1(chr5:91411708-131319563)x1 copy number loss See cases [RCV000143746] Chr5:91411708..131319563 [GRCh38]
Chr5:90707525..130655256 [GRCh37]
Chr5:90743281..130683155 [NCBI36]
Chr5:5q14.3-31.1
pathogenic
GRCh38/hg38 5q14.3-21.1(chr5:87376883-101524443)x1 copy number loss See cases [RCV000050945] Chr5:87376883..101524443 [GRCh38]
Chr5:86672700..100860147 [GRCh37]
Chr5:86708456..100888046 [NCBI36]
Chr5:5q14.3-21.1
pathogenic
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1
pathogenic
GRCh38/hg38 5q14.3-15(chr5:88936770-94102018)x1 copy number loss See cases [RCV000053480] Chr5:88936770..94102018 [GRCh38]
Chr5:88232587..93437723 [GRCh37]
Chr5:88268343..93463479 [NCBI36]
Chr5:5q14.3-15
pathogenic
GRCh38/hg38 5q14.3-21.2(chr5:89081352-104687248)x1 copy number loss See cases [RCV000053516] Chr5:89081352..104687248 [GRCh38]
Chr5:88377169..104022949 [GRCh37]
Chr5:88412925..104050848 [NCBI36]
Chr5:5q14.3-21.2
pathogenic
GRCh38/hg38 5q14.3-15(chr5:91386552-98365880)x1 copy number loss See cases [RCV000053519] Chr5:91386552..98365880 [GRCh38]
Chr5:90682369..97701584 [GRCh37]
Chr5:90718125..97729488 [NCBI36]
Chr5:5q14.3-15
pathogenic
GRCh38/hg38 5q15(chr5:93078983-95529159)x1 copy number loss See cases [RCV000053521] Chr5:93078983..95529159 [GRCh38]
Chr5:92414689..94864863 [GRCh37]
Chr5:92440445..94890619 [NCBI36]
Chr5:5q15
pathogenic
GRCh38/hg38 5q15(chr5:93598243-94237822)x1 copy number loss See cases [RCV000053522] Chr5:93598243..94237822 [GRCh38]
Chr5:92933949..93573527 [GRCh37]
Chr5:92959705..93599283 [NCBI36]
Chr5:5q15
pathogenic
GRCh38/hg38 5q15(chr5:93405010-97716265)x3 copy number gain See cases [RCV000053285] Chr5:93405010..97716265 [GRCh38]
Chr5:92740716..97051969 [GRCh37]
Chr5:92766472..97077725 [NCBI36]
Chr5:5q15
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR2277 COSMIC
Ensembl Genes ENSG00000284336 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000515916 ENTREZGENE
GTEx ENSG00000284336 GTEx
HGNC ID HGNC:37314 ENTREZGENE
Human Proteome Map MIR2277 Human Proteome Map
miRBase MI0011284 ENTREZGENE
NCBI Gene 100313887 ENTREZGENE
PharmGKB PA165660378 PharmGKB
RNAcentral URS00000D6C3F RNACentral
  URS00003CA515 RNACentral
  URS000075D14E RNACentral