Col4a5<sup>em2Matsu</sup> (collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 2, Matsu) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Col4a5em2Matsu (collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 2, Matsu) Rattus norvegicus
Analyze
Symbol: Col4a5em2Matsu
Name: collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 2, Matsu
RGD ID: 329969892
Description: Genome editing was performed using the rGONAD method to produce three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em2 mutant carries a premature stop coden after 15 amino acids due to insertion of a 42bp stop codon.
ASSOCIATED WITH premature death; ASSOCIATED WITH proteinuria
Type: allele  of Col4a5  
Previously known as: Col4a5^[em2Matsu]; WKY-Col4a5em2Matsu
Is Marker For: Strains:   WKY-Col4a5em2Matsu  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
proteinuria  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Creation of X-linked Alport syndrome rat model with Col4a5 deficiency. Namba M, etal., Sci Rep. 2021 Oct 21;11(1):20836. doi: 10.1038/s41598-021-00354-y.

Genomics


Related Rat Strains
The following Strains have been annotated to Col4a5em2Matsu
WKY-Col4a5em2Matsu    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-11 Col4a5em2Matsu  collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 2, Matsu  WKY-Col4a5em2Matsu  collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 2, Matsu  Symbol changed 629549 APPROVED