Pemt (phosphatidylethanolamine N-methyltransferase) - Rat Genome Database

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Gene: Pemt (phosphatidylethanolamine N-methyltransferase) Rattus norvegicus
Analyze
Symbol: Pemt
Name: phosphatidylethanolamine N-methyltransferase
RGD ID: 3297
Description: Enables phosphatidylethanolamine N-methyltransferase activity and phosphatidylethanolamine binding activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; phosphatidylcholine biosynthetic process; and positive regulation of lipoprotein metabolic process. Located in brush border membrane and sarcolemma. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; choline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PE N-methyltransferase; PEAMT; Pempt; PHOMETH; phospholipid methyltransferase; PLMT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,775,910 - 44,849,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,775,911 - 44,850,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,476,153 - 49,542,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,966,515 - 49,032,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,470,127 - 44,536,484 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,339,821 - 46,404,640 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,339,821 - 46,404,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,096,652 - 46,161,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11046,313,743 - 46,316,512 (-)NCBI
Celera1044,035,617 - 44,101,504 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
GW 4064  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sarin  (ISO)
SCH 23390  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver. Cui Z, etal., J Biol Chem 1993 Aug 5;268(22):16655-63.
2. Suppression of rat hepatoma cell growth by expression of phosphatidylethanolamine N-methyltransferase-2. Cui Z, etal., J Biol Chem. 1994 Oct 7;269(40):24531-3.
3. Increase of phosphatidylethanolamine N-methyltransferase activity in the small bowel brush-border membrane after massive intestinal distal resection in rats. Furtado VC, etal., APMIS. 2007 Jul;115(7):814-9.
4. Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT. Gao X, etal., J Lipid Res. 2015 Sep;56(9):1701-10. doi: 10.1194/jlr.M059287. Epub 2015 Jun 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats. Hartz CS, etal., J Nutr. 2006 Dec;136(12):3005-9.
8. Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats. Hirche F, etal., Ann Nutr Metab. 2006;50(2):139-46. Epub 2006 Jan 3.
9. Adriamycin depresses in vivo and in vitro phosphatidylethanolamine N-methylation in rat heart sarcolemma. Iliskovic N, etal., Mol Cell Biochem. 1997 Nov;176(1-2):235-40.
10. Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency. Johnson PI and Blusztajn JK, Neurochem Res. 1998 May;23(5):583-7.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. Kharbanda KK, etal., J Hepatol. 2007 Feb;46(2):314-21. Epub 2006 Oct 26.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Inhibition of phosphatidylcholine synthesis via the phosphatidylethanolamine methylation pathway impairs incorporation of bulk lipids into VLDL in cultured rat hepatocytes. Nishimaki-Mogami T, etal., J Lipid Res. 2002 Jul;43(7):1035-45.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase. Samborski RW, etal., J Lipid Res. 1993 Jan;34(1):125-37.
21. Alteration in the phosphatidylcholine biosynthesis of rat liver microsomes caused by vitamin B6 deficiency. She QB, etal., Biosci Biotechnol Biochem. 1995 Feb;59(2):163-7.
Additional References at PubMed
PMID:12072432   PMID:12477932   PMID:12482759   PMID:14651853   PMID:16756957   PMID:24270810   PMID:25667419   PMID:27869233  


Genomics

Comparative Map Data
Pemt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,775,910 - 44,849,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,775,911 - 44,850,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,476,153 - 49,542,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,966,515 - 49,032,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,470,127 - 44,536,484 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,339,821 - 46,404,640 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,339,821 - 46,404,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,096,652 - 46,161,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11046,313,743 - 46,316,512 (-)NCBI
Celera1044,035,617 - 44,101,504 (-)NCBICelera
Cytogenetic Map10q22NCBI
PEMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,505,563 - 17,592,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,505,563 - 17,591,708 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,408,877 - 17,495,022 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,349,602 - 17,435,719 (-)NCBINCBI36Build 36hg18NCBI36
Build 341717,349,603 - 17,421,504NCBI
Celera1718,348,298 - 18,434,406 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,161,232 - 17,247,817 (-)NCBIHuRef
CHM1_11717,417,546 - 17,503,772 (-)NCBICHM1_1
T2T-CHM13v2.01717,452,171 - 17,538,580 (-)NCBIT2T-CHM13v2.0
Pemt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,861,440 - 59,937,394 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,861,440 - 59,937,315 (-)EnsemblGRCm39 Ensembl
GRCm381159,970,614 - 60,046,561 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,970,614 - 60,046,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,784,119 - 59,850,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,786,812 - 59,853,034 (-)NCBIMGSCv36mm8
MGSCv361160,507,197 - 60,573,128 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.81NCBI
Pemt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577367,288 - 443,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577365,031 - 443,138 (+)NCBIChiLan1.0ChiLan1.0
PEMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11756,733,691 - 56,819,906 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01733,703,800 - 33,790,470 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,651,026 - 38,737,202 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,651,024 - 38,737,202 (+)Ensemblpanpan1.1panPan2
PEMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,871,685 - 41,960,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,872,108 - 41,960,828 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,009,850 - 42,098,909 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,977,629 - 42,066,973 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,977,968 - 42,066,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,944,901 - 42,034,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,892,196 - 41,981,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,084,267 - 42,173,368 (+)NCBIUU_Cfam_GSD_1.0
Pemt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,659,756 - 61,735,456 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,128,616 - 1,207,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,131,792 - 1,207,460 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11260,880,367 - 60,919,279 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,139,567 - 63,158,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PEMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,540,096 - 16,626,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,539,985 - 16,611,279 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,287,408 - 4,373,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pemt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,817,915 - 3,908,888 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,818,115 - 3,907,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pemt
411 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:66
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000004488
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat

Markers in Region
RH143802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,812,078 - 44,812,192 (+)MAPPERmRatBN7.2
Rnor_6.01046,376,000 - 46,376,113NCBIRnor6.0
Rnor_5.01046,132,069 - 46,132,182UniSTSRnor5.0
Celera1044,071,185 - 44,071,298UniSTS
RH 3.4 Map10473.89UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 31 31 17
Low 3 43 26 10 19 10 8 11 74 35 24 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083698   ⟹   ENSRNOP00000074801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,775,913 - 44,849,978 (-)Ensembl
Rnor_6.0 Ensembl1046,339,821 - 46,404,642 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101753   ⟹   ENSRNOP00000093518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,775,911 - 44,850,013 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112526   ⟹   ENSRNOP00000084752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,775,911 - 44,850,013 (-)Ensembl
RefSeq Acc Id: NM_013003   ⟹   NP_037135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,775,911 - 44,842,425 (-)NCBI
Rnor_6.01046,339,821 - 46,404,640 (-)NCBI
Rnor_5.01046,096,652 - 46,161,545 (-)NCBI
Celera1044,035,617 - 44,101,504 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085286   ⟹   XP_038941214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,775,910 - 44,849,990 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037135   ⟸   NM_013003
- UniProtKB: Q5BK89 (UniProtKB/Swiss-Prot),   Q08388 (UniProtKB/Swiss-Prot),   A6HF23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074801   ⟸   ENSRNOT00000083698
RefSeq Acc Id: XP_038941214   ⟸   XM_039085286
- Peptide Label: isoform X1
- UniProtKB: A0A8L2RBC3 (UniProtKB/TrEMBL),   A0A8I6AJS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093518   ⟸   ENSRNOT00000101753
RefSeq Acc Id: ENSRNOP00000084752   ⟸   ENSRNOT00000112526

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08388-F1-model_v2 AlphaFold Q08388 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697245
Promoter ID:EPDNEW_R7769
Type:initiation region
Name:Pemt_1
Description:phosphatidylethanolamine N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,404,686 - 46,404,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3297 AgrOrtholog
BioCyc Gene G2FUF-24867 BioCyc
BioCyc Pathway PWY-6825 [phosphatidylcholine biosynthesis V] BioCyc
Ensembl Genes ENSRNOG00000054423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083698 ENTREZGENE
  ENSRNOT00000083698.2 UniProtKB/TrEMBL
  ENSRNOT00000101753.1 UniProtKB/TrEMBL
  ENSRNOT00000112526.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325819 IMAGE-MGC_LOAD
InterPro PEMT/MFAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phopholipid_MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25511 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108741 IMAGE-MGC_LOAD
NCBI Gene 25511 ENTREZGENE
PANTHER PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pemt PhenoGen
PIRSF PEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_PEMT_PEM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054423 RatGTEx
UniProt A0A8I6AJS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAY9_RAT UniProtKB/TrEMBL
  A0A8L2RBC3 ENTREZGENE, UniProtKB/TrEMBL
  A6HF23 ENTREZGENE, UniProtKB/TrEMBL
  PEMT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BK89 ENTREZGENE
UniProt Secondary Q5BK89 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pemt  phosphatidylethanolamine N-methyltransferase      Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Pempt  Phosphatidylethanolamine N-methyltransferase      Symbol withdrawn, duplicate of Pemt (RGD:3297) 67952 WITHDRAWN