PDE6B (phosphodiesterase 6B) - Rat Genome Database

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Gene: PDE6B (phosphodiesterase 6B) Pan paniscus
Analyze
Symbol: PDE6B
Name: phosphodiesterase 6B
RGD ID: 329330958
Description: ENCODES a protein that exhibits 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN detection of light stimulus (ortholog); retina development in camera-type eye (ortholog); retinal cell apoptotic process (ortholog); PARTICIPATES IN altered visual phototransduction pathway; retinitis pigmentosa pathway; visual phototransduction pathway; ASSOCIATED WITH Animal Disease Models (ortholog); cherubism (ortholog); cone-rod dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred); photoreceptor outer segment membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23866,524 - 979,062 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14831,856 - 936,701 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl4646,516 - 701,680 (+)Ensemblpanpan1.1panPan2


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDE6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23866,524 - 979,062 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14831,856 - 936,701 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl4646,516 - 701,680 (+)Ensemblpanpan1.1panPan2
PDE6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384625,573 - 670,782 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4625,573 - 670,782 (+)EnsemblGRCh38hg38GRCh38
GRCh374619,362 - 664,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364609,373 - 654,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 344609,394 - 654,542NCBI
Celera4559,794 - 605,337 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4594,501 - 639,532 (+)NCBIHuRef
CHM1_14619,152 - 664,469 (+)NCBICHM1_1
T2T-CHM13v2.04586,384 - 670,456 (+)NCBIT2T-CHM13v2.0
Pde6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,536,239 - 108,579,609 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,536,257 - 108,580,263 (+)EnsemblGRCm39 Ensembl
GRCm385108,388,373 - 108,431,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,388,391 - 108,432,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv375108,817,392 - 108,860,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,628,742 - 108,672,038 (+)NCBIMGSCv36mm8
Celera5105,508,147 - 105,551,677 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.07NCBI
Pde6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,468,302 - 1,511,435 (-)NCBIGRCr8
mRatBN7.2141,323,310 - 1,366,450 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,323,310 - 1,366,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,205,011 - 1,248,120 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,506,768 - 2,549,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,203,442 - 1,246,548 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,328,690 - 2,371,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,328,750 - 2,371,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,327,104 - 2,370,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,871,037 - 1,914,170 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,871,039 - 1,914,188 (-)NCBI
Celera141,345,195 - 1,388,316 (-)NCBICelera
Cytogenetic Map14p22NCBI
Pde6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514234,972 - 279,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514234,972 - 279,420 (+)NCBIChiLan1.0ChiLan1.0
PDE6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,746,571 - 91,775,372 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,746,571 - 91,775,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha394,212,075 - 94,240,253 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0392,746,064 - 92,774,237 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,746,065 - 92,774,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,917,662 - 91,945,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,972,847 - 92,000,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,354,937 - 92,383,124 (-)NCBIUU_Cfam_GSD_1.0
Pde6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,717,209 - 68,770,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,417,453 - 22,472,185 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,418,037 - 22,472,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl880,378 - 110,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1880,378 - 111,960 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28131,905 - 148,422 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12748,117,495 - 48,168,727 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2748,118,190 - 48,162,368 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660514,503,685 - 4,551,815 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,372,072 - 26,413,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475526,372,040 - 26,413,464 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052406   ⟹   ENSPPAP00000029556
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4646,516 - 701,680 (+)Ensembl
RefSeq Acc Id: XM_055111087   ⟹   XP_054967062
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23867,491 - 979,062 (+)NCBI
NHGRI_mPanPan14832,827 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111088   ⟹   XP_054967063
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23867,491 - 979,062 (+)NCBI
NHGRI_mPanPan14832,827 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111089   ⟹   XP_054967064
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23867,472 - 979,062 (+)NCBI
NHGRI_mPanPan14832,804 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111090   ⟹   XP_054967065
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23867,491 - 979,062 (+)NCBI
NHGRI_mPanPan14832,827 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111092   ⟹   XP_054967067
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23866,524 - 979,062 (+)NCBI
NHGRI_mPanPan14831,856 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111093   ⟹   XP_054967068
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23867,491 - 979,062 (+)NCBI
NHGRI_mPanPan14832,827 - 936,701 (+)NCBI
RefSeq Acc Id: XM_055111094   ⟹   XP_054967069
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23866,524 - 979,062 (+)NCBI
NHGRI_mPanPan14831,856 - 936,701 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000029556   ⟸   ENSPPAT00000052406
RefSeq Acc Id: XP_054967067   ⟸   XM_055111092
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967069   ⟸   XM_055111094
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054967064   ⟸   XM_055111089
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967062   ⟸   XM_055111087
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967068   ⟸   XM_055111093
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967063   ⟸   XM_055111088
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967065   ⟸   XM_055111090
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BSH8 (UniProtKB/TrEMBL)
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037791 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052406.1 UniProtKB/TrEMBL
Gene3D-CATH 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene PDE6B ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
  ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA UniProtKB/TrEMBL
Pfam GAF UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A2R9BSH8 ENTREZGENE, UniProtKB/TrEMBL