6620401K05Rik (RIKEN cDNA 6620401K05 gene) - Rat Genome Database

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Gene: 6620401K05Rik (RIKEN cDNA 6620401K05 gene) Mus musculus
Analyze
Symbol: 6620401K05Rik (Ensembl: Atrip)
Name: RIKEN cDNA 6620401K05 gene (Ensembl:ATR interacting protein)
RGD ID: 32722963
MGI Page MGI
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within DNA damage response. Part of ATR-ATRIP complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Used to study Seckel syndrome. Orthologous to human ATRIP (ATR interacting protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; triptonide.
Type: protein-coding
Previously known as: ATM and Rad3 related interacting protein; ATR-interacting protein; Atrip
RGD Orthologs
Human
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,888,815 - 108,903,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,887,001 - 108,903,192 (-)EnsemblGRCm39 Ensembl
GRCm389109,059,747 - 109,074,124 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,057,933 - 109,074,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,962,261 - 108,976,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9108,618,529 - 108,632,920 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ATR-ATRIP complex  (IPI,ISO)
nucleoplasm  (ISO)
nucleus  (NAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073  


Genomics

Comparative Map Data
6620401K05Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,888,815 - 108,903,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,887,001 - 108,903,192 (-)EnsemblGRCm39 Ensembl
GRCm389109,059,747 - 109,074,124 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,057,933 - 109,074,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,962,261 - 108,976,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9108,618,529 - 108,632,920 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
ATRIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,446,737 - 48,467,645 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,446,710 - 48,467,645 (+)EnsemblGRCh38hg38GRCh38
GRCh37348,488,141 - 48,509,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef348,542,265 - 48,561,084 (+)NCBIHuRef
CHM1_1348,440,399 - 48,459,354 (+)NCBICHM1_1
T2T-CHM13v2.0348,474,745 - 48,495,650 (+)NCBIT2T-CHM13v2.0
ATRIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,626,828 - 40,642,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,626,831 - 40,642,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,544,311 - 40,560,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,112,221 - 41,128,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,112,229 - 41,128,080 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,349,655 - 40,365,496 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,754,240 - 40,770,084 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,034,936 - 41,050,787 (-)NCBIUU_Cfam_GSD_1.0


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK020102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000045011   ⟹   ENSMUSP00000044831
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,888,815 - 108,903,192 (-)Ensembl
GRCm38.p6 Ensembl9109,059,747 - 109,074,124 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128062   ⟹   ENSMUSP00000118499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,887,538 - 108,889,406 (-)Ensembl
GRCm38.p6 Ensembl9109,058,470 - 109,060,338 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159614   ⟹   ENSMUSP00000124854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,889,729 - 108,894,461 (-)Ensembl
GRCm38.p6 Ensembl9109,060,661 - 109,065,393 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160217   ⟹   ENSMUSP00000125264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,887,001 - 108,903,139 (-)Ensembl
GRCm38.p6 Ensembl9109,057,933 - 109,074,071 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,887,004 - 108,903,188 (-)Ensembl
GRCm38.p6 Ensembl9109,057,936 - 109,074,120 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161163
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,888,878 - 108,891,357 (-)Ensembl
GRCm38.p6 Ensembl9109,059,810 - 109,062,289 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161270
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,896,533 - 108,898,587 (-)Ensembl
GRCm38.p6 Ensembl9109,067,465 - 109,069,519 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161521   ⟹   ENSMUSP00000125615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,888,853 - 108,903,120 (-)Ensembl
GRCm38.p6 Ensembl9109,059,785 - 109,074,052 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194199
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,900,814 - 108,903,134 (-)Ensembl
GRCm38.p6 Ensembl9109,071,746 - 109,074,066 (-)Ensembl
RefSeq Acc Id: NM_172774   ⟹   NP_766362
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,888,815 - 108,903,192 (-)NCBI
GRCm389109,059,747 - 109,074,124 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein BAB31994 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000044831.3
  ENSMUSP00000118499.3
  ENSMUSP00000124854.2
  ENSMUSP00000125264.2
  ENSMUSP00000125615.2
RefSeq Acc Id: NP_766362   ⟸   NM_172774
- Sequence:
Ensembl Acc Id: ENSMUSP00000124854   ⟸   ENSMUST00000159614
Ensembl Acc Id: ENSMUSP00000044831   ⟸   ENSMUST00000045011
Ensembl Acc Id: ENSMUSP00000125264   ⟸   ENSMUST00000160217
Ensembl Acc Id: ENSMUSP00000118499   ⟸   ENSMUST00000128062
Ensembl Acc Id: ENSMUSP00000125615   ⟸   ENSMUST00000161521

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BMG1-F1-model_v2 AlphaFold Q8BMG1 1-785 view protein structure

Promoters
RGD ID:8670956
Promoter ID:EPDNEW_M13509
Type:initiation region
Name:Atrip-trex1_2
Description:Mus musculus Atrip-Trex1 readthrough (Atrip-trex1), long non-codingRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13507  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389109,074,078 - 109,074,138EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000025646 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045011.9 UniProtKB/Swiss-Prot
  ENSMUST00000128062.3 UniProtKB/TrEMBL
  ENSMUST00000159614.3 UniProtKB/TrEMBL
  ENSMUST00000160217.8 UniProtKB/TrEMBL
  ENSMUST00000161521.8 UniProtKB/TrEMBL
InterPro ATRIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235610 UniProtKB/Swiss-Prot
MGD MGI:1925349 ENTREZGENE
NCBI Gene 6620401K05Rik ENTREZGENE
PANTHER ATR-INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28594 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen 6620401K05Rik PhenoGen
UniProt ATRIP_MOUSE UniProtKB/Swiss-Prot
  D3YUE0_MOUSE UniProtKB/TrEMBL
  E9Q6L5_MOUSE UniProtKB/TrEMBL
  F6U6D4_MOUSE UniProtKB/TrEMBL
  I6L9G2_MOUSE UniProtKB/TrEMBL
  Q3T9R3_MOUSE UniProtKB/TrEMBL
  Q9CRN1_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QLS8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 6620401K05Rik  RIKEN cDNA 6620401K05 gene  Atrip  ATR interacting protein  Symbol and/or name change 5135510 APPROVED