MIR297 (microRNA 297) - Rat Genome Database

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Gene: MIR297 (microRNA 297) Homo sapiens
Analyze
Symbol: MIR297
Name: microRNA 297
RGD ID: 3184212
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-297; MIRN297
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4110,860,582 - 110,860,647 (-)EnsemblGRCh38hg38GRCh38
GRCh384110,860,582 - 110,860,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374111,781,738 - 111,781,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera4109,075,577 - 109,075,642 (-)NCBI
Cytogenetic Map4q25NCBI
HuRef4107,513,333 - 107,513,398 (-)NCBIHuRef
CHM1_14111,758,888 - 111,758,953 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aniridia  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cisplatin  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
Sporidesmin  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Aniridia  (IAGP)
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17322031   PMID:22676135   PMID:24158111   PMID:25336585   PMID:27554041   PMID:28091918   PMID:30921508   PMID:31945608   PMID:31973814  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ABCC2hsa-miR-297OncomiRDBexternal_infoNANA22676135

Predicted Targets
Summary Value
Count of predictions:15023
Count of gene targets:6228
Count of transcripts:11126
Interacting mature miRNAs:hsa-miR-297
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system musculoskeletal system renal system reproductive system adipose tissue
High
Medium
Low 2 1 1 2 1
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_030643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC024198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000401142
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4110,860,582 - 110,860,647 (-)Ensembl
RefSeq Acc Id: NR_030643
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384110,860,582 - 110,860,647 (-)NCBI
GRCh374111,781,738 - 111,781,803 (-)RGD
Celera4109,075,577 - 109,075,642 (-)RGD
HuRef4107,513,333 - 107,513,398 (-)RGD
CHM1_14111,758,888 - 111,758,953 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q25(chr4:110818535-111610698)x1 copy number loss See cases [RCV000133694] Chr4:110818535..111610698 [GRCh38]
Chr4:111739691..112531854 [GRCh37]
Chr4:111959140..112751303 [NCBI36]
Chr4:4q25
uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
NC_000004.10:g.111994000_115504000del3510001 deletion Congenital aniridia [RCV000257787] Chr4:110853395..114363395 [GRCh38]
Chr4:111774551..115284551 [GRCh37]
Chr4:111994000..115504000 [NCBI36]
Chr4:4q25-26
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR297 COSMIC
Ensembl Genes ENSG00000215961 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000401142 ENTREZGENE
GTEx ENSG00000215961 GTEx
HGNC ID HGNC:33691 ENTREZGENE
Human Proteome Map MIR297 Human Proteome Map
miRBase MI0005775 ENTREZGENE
NCBI Gene 100126354 ENTREZGENE
OMIM 615520 OMIM
PharmGKB PA164722625 PharmGKB
RNAcentral URS000075A3FD RNACentral
  URS000075D760 RNACentral