Mcpt10 (mast cell protease 10) - Rat Genome Database

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Gene: Mcpt10 (mast cell protease 10) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt10
Name: mast cell protease 10
RGD ID: 3063
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle; INTERACTS WITH 3,7-dihydropurine-6-thione; Alisol A; Alisol B.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GLP II; GLP-2; granzyme-like protein 2; granzyme-like protein II; mast cell protease X; rMCP-10; rMCP-X
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,885,728 - 33,888,787 (-)NCBIGRCr8
mRatBN7.21529,915,483 - 29,918,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,915,483 - 29,918,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,571,852 - 31,574,829 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,719,053 - 32,722,030 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,961,466 - 30,964,443 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,644,471 - 34,647,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,644,464 - 34,694,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X6,578,813 - 6,581,777 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,484,090 - 34,487,054 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,448,011 - 34,502,106 (+)NCBI
Celera1529,376,420 - 29,379,384 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum. Amerik AYu, etal., FEBS Lett 1993 Jun 14;324(2):226-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mcpt10
229 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH130893  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01534,667,438 - 34,668,061NCBIRnor6.0
Rnor_5.01538,557,543 - 38,558,166UniSTSRnor5.0
Rnor_5.0X6,578,989 - 6,579,613UniSTSRnor5.0
RH 3.4 Map15260.09UniSTS
Cytogenetic Map15p12UniSTS
Cytogenetic Map15p13UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027950   ⟹   ENSRNOP00000027950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,860,148 (+)Ensembl
Rnor_6.0 Ensembl1534,644,476 - 34,694,209 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000049315   ⟹   ENSRNOP00000043846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,981 - 29,860,148 (+)Ensembl
Rnor_6.0 Ensembl1534,667,347 - 34,670,217 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072426   ⟹   ENSRNOP00000067099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,514 - 29,860,148 (+)Ensembl
Rnor_6.0 Ensembl1534,644,558 - 34,647,421 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079505   ⟹   ENSRNOP00000073163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,644,477 - 34,694,180 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079782   ⟹   ENSRNOP00000075590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,130 - 29,860,145 (+)Ensembl
Rnor_6.0 Ensembl1534,644,477 - 34,694,210 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080221   ⟹   ENSRNOP00000070668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,644,464 - 34,694,244 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083314   ⟹   ENSRNOP00000070193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,691,246 - 34,693,034 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097106   ⟹   ENSRNOP00000083076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,915,483 - 29,917,777 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099690   ⟹   ENSRNOP00000097551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,802,380 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101483   ⟹   ENSRNOP00000092595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,861 - 29,802,383 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106620   ⟹   ENSRNOP00000083423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,915,483 - 29,918,127 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107633   ⟹   ENSRNOP00000086840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,915,486 - 29,918,511 (-)Ensembl
RefSeq Acc Id: NM_017146   ⟹   NP_058842
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,885,728 - 33,888,712 (-)NCBI
mRatBN7.21529,915,483 - 29,918,467 (-)NCBI
RefSeq Acc Id: XM_039093844   ⟹   XP_038949772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,885,826 - 33,888,787 (-)NCBI
mRatBN7.21529,915,579 - 29,918,540 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000070668   ⟸   ENSRNOT00000080221
RefSeq Acc Id: ENSRNOP00000075590   ⟸   ENSRNOT00000079782
RefSeq Acc Id: ENSRNOP00000073163   ⟸   ENSRNOT00000079505
RefSeq Acc Id: ENSRNOP00000067099   ⟸   ENSRNOT00000072426
RefSeq Acc Id: ENSRNOP00000070193   ⟸   ENSRNOT00000083314
RefSeq Acc Id: ENSRNOP00000043846   ⟸   ENSRNOT00000049315
RefSeq Acc Id: ENSRNOP00000027950   ⟸   ENSRNOT00000027950
RefSeq Acc Id: XP_038949772   ⟸   XM_039093844
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000083423   ⟸   ENSRNOT00000106620
RefSeq Acc Id: ENSRNOP00000083076   ⟸   ENSRNOT00000097106
RefSeq Acc Id: ENSRNOP00000086840   ⟸   ENSRNOT00000107633
RefSeq Acc Id: ENSRNOP00000097551   ⟸   ENSRNOT00000099690
RefSeq Acc Id: ENSRNOP00000092595   ⟸   ENSRNOT00000101483
RefSeq Acc Id: NP_058842   ⟸   NM_017146
- Peptide Label: precursor
- UniProtKB: Q06606 (UniProtKB/Swiss-Prot),   A0A8I6A223 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97594-F1-model_v2 AlphaFold P97594 1-248 view protein structure
AF-Q06606-F1-model_v2 AlphaFold Q06606 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3063 AgrOrtholog
BioCyc Gene G2FUF-13663 BioCyc
Ensembl Genes ENSRNOG00000049991 Ensembl
  ENSRNOG00000063482 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000068082 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012129 UniProtKB/Swiss-Prot
  ENSRNOG00055012135 UniProtKB/Swiss-Prot
  ENSRNOG00060024605 UniProtKB/Swiss-Prot
  ENSRNOG00060024972 UniProtKB/Swiss-Prot
  ENSRNOG00065030859 UniProtKB/Swiss-Prot
  ENSRNOG00065031370 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049315.5 UniProtKB/TrEMBL
  ENSRNOT00000072426.3 UniProtKB/TrEMBL
  ENSRNOT00000097106.1 UniProtKB/TrEMBL
  ENSRNOT00000099690.1 UniProtKB/Swiss-Prot
  ENSRNOT00000101483.1 UniProtKB/TrEMBL
  ENSRNOT00000106620.1 UniProtKB/TrEMBL
  ENSRNOT00000107633 ENTREZGENE
  ENSRNOT00000107633.1 UniProtKB/Swiss-Prot
  ENSRNOT00055020613 UniProtKB/Swiss-Prot
  ENSRNOT00055020623 UniProtKB/Swiss-Prot
  ENSRNOT00060042575 UniProtKB/Swiss-Prot
  ENSRNOT00060043290 UniProtKB/Swiss-Prot
  ENSRNOT00065053190 UniProtKB/Swiss-Prot
  ENSRNOT00065054080 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54269 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAST CELL PROTEASE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcpt10 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049991 RatGTEx
  ENSRNOG00000063482 RatGTEx
  ENSRNOG00000068082 RatGTEx
  ENSRNOG00055012129 RatGTEx
  ENSRNOG00055012135 RatGTEx
  ENSRNOG00060024605 RatGTEx
  ENSRNOG00060024972 RatGTEx
  ENSRNOG00065030859 RatGTEx
  ENSRNOG00065031370 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY26_RAT UniProtKB/TrEMBL
  A0A8I5ZW69_RAT UniProtKB/TrEMBL
  A0A8I5ZX66_RAT UniProtKB/TrEMBL
  A0A8I6A223 ENTREZGENE
  A0A8I6AHB8_RAT UniProtKB/TrEMBL
  A0A8L2QXY5_RAT UniProtKB/TrEMBL
  A6KH76_RAT UniProtKB/TrEMBL
  GRZ2_RAT UniProtKB/Swiss-Prot
  MCPT8_RAT UniProtKB/Swiss-Prot
  Q06606 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mcpt10  mast cell protease 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in duodenum 632831