Esyt1 (extended synaptotagmin 1) - Rat Genome Database

Name: Esyt1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Esyt1 (extended synaptotagmin 1) Rattus norvegicus

Analyze

Symbol:

Esyt1

Name:

extended synaptotagmin 1

RGD ID:

3053

Description:

Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in endoplasmic reticulum membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human ESYT1 (extended synaptotagmin 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E-Syt1; extended synaptotagmin protein 1; extended synaptotagmin-1; extended synaptotagmin-like protein 1; Fam62a; family with sequence similarity 62 (C2 domain containing), member A; Mbc2; membrane bound C2 domain containing protein; membrane-bound C2 domain-containing protein; MGC124625; vp115

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ESYT1 (extended synaptotagmin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Esyt1 (extended synaptotagmin-like protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Esyt1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ESYT1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ESYT1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Esyt1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ESYT1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ESYT1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Esyt1 (extended synaptotagmin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NUMBL (NUMB like endocytic adaptor protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ESYT1 (extended synaptotagmin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Esyt1 (extended synaptotagmin-like protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	esyt1a (extended synaptotagmin-like protein 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	esyt1b (extended synaptotagmin-like protein 1b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Esyt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TCB1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TCB2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TCB3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	esyt-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	esyt1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	928,848 - 946,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	928,848 - 946,199 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,690,831 - 3,708,186 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,566,813 - 5,584,172 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,864,442 - 5,881,776 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,924,216 - 2,941,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,924,603 - 2,941,122 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,897,632 - 2,914,841 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,790,700 - 1,808,060 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,791,039 - 1,808,005 (-)	NCBI
Celera	7	802,008 - 819,338 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

choline (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

dieldrin (ISO)

diuron (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenthion (ISO)

folic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

methapyrilene (ISO)

methotrexate (ISO)

nickel atom (ISO)

paracetamol (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

trovafloxacin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum-plasma membrane tethering (IEA)

intermembrane lipid transfer (IEA,ISO,ISS)

phospholipid transport (IEA)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA,ISO,ISS)

extrinsic component of cytoplasmic side of plasma membrane (IBA)

plasma membrane (IEA)

Molecular Function

calcium ion binding (IBA)

calcium-dependent phospholipid binding (IBA)

identical protein binding (IEA,ISO)

lipid binding (IEA)

metal ion binding (IEA)

phosphatidylcholine binding (IBA)

phosphatidylethanolamine binding (IBA)

phosphatidylinositol binding (IBA)

phospholipid transfer activity (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains.	Morris NJ, etal., Biochim Biophys Acta 1999 May 18;1431(2):525-30.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:17110338	PMID:19946888	PMID:22871113	PMID:23791178	PMID:27065097

Genomics

Comparative Map Data

Esyt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	928,848 - 946,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	928,848 - 946,199 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,690,831 - 3,708,186 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,566,813 - 5,584,172 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,864,442 - 5,881,776 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,924,216 - 2,941,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,924,603 - 2,941,122 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,897,632 - 2,914,841 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,790,700 - 1,808,060 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,791,039 - 1,808,005 (-)	NCBI
Celera	7	802,008 - 819,338 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

ESYT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,128,267 - 56,144,674 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,118,250 - 56,144,674 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,522,051 - 56,538,458 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,808,321 - 54,824,722 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	56,174,129 - 56,190,606 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,561,123 - 53,577,517 (+)	NCBI		HuRef
CHM1_1	12	56,489,351 - 56,505,826 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,095,865 - 56,112,273 (+)	NCBI		T2T-CHM13v2.0

Esyt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,346,117 - 128,361,728 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,345,834 - 128,361,740 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,510,248 - 128,525,859 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,509,965 - 128,525,871 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	127,947,304 - 127,962,915 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,913,197 - 127,928,808 (-)	NCBI		MGSCv36	mm8
Celera	10	130,902,178 - 130,917,817 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	76.85	NCBI

Esyt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,733,071 - 3,745,876 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,732,968 - 3,746,856 (+)	NCBI	ChiLan1.0	ChiLan1.0

ESYT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	38,184,345 - 38,200,835 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,770,870 - 32,787,352 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,021,770 - 33,037,988 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,021,770 - 33,037,988 (-)	Ensembl	panpan1.1		panPan2

ESYT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	448,807 - 462,154 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	448,881 - 461,332 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	510,556 - 525,658 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	455,687 - 470,823 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	455,519 - 470,822 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	433,143 - 448,267 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	676,264 - 691,357 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	800,278 - 815,384 (+)	NCBI		UU_Cfam_GSD_1.0

Esyt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,318,429 - 58,333,665 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	538,794 - 552,036 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936646	536,561 - 551,806 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ESYT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,514,510 - 21,535,929 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,517,956 - 21,535,320 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	22,986,045 - 23,003,135 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ESYT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,066,624 - 52,085,114 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	52,068,884 - 52,085,726 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	193,899,607 - 193,916,061 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Esyt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,863,094 - 11,877,642 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	11,863,094 - 11,891,632 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Esyt1
53 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	65
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000006119
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat

Markers in Region

RH140472

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	928,908 - 929,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	2,924,277 - 2,924,485	NCBI	Rnor6.0
Rnor_5.0	7	2,897,693 - 2,897,901	UniSTS	Rnor5.0
RGSC_v3.4	7	1,790,761 - 1,790,969	UniSTS	RGSC3.4
Celera	7	802,069 - 802,277	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	68	35	39	11	8
Low									6		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF099138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000082107 ⟹ ENSRNOP00000070299

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	928,848 - 946,199 (-)	Ensembl
Rnor_6.0 Ensembl	7	2,924,603 - 2,941,122 (-)	Ensembl

RefSeq Acc Id:

NM_017249 ⟹ NP_058945

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	928,848 - 946,199 (-)	NCBI
Rnor_6.0	7	2,924,216 - 2,941,213 (-)	NCBI
Rnor_5.0	7	2,897,632 - 2,914,841 (-)	NCBI
RGSC_v3.4	7	1,790,700 - 1,808,060 (-)	RGD
Celera	7	802,008 - 819,338 (-)	RGD

Sequence:

show sequence

CCCGGGGGAGCACCATATATTACTGGGGGGAGCCGGAGCAGACACTGAGCTGTCTGCAGCTGCT
CGGGCGGGCACTCCTAGAAGCCGCCCCATGGAGCGCTCCCCTGAAGAGGGCGCCGGCCCCGAGC
CCTCAGGGCAGTCCCCGGCCACGGACTCCACGCGGGAGCGGGACGGGGGCTCTGGGGTCCCACC
TGCCGGCCCAGGTGCGGCGAGCGAGGCCCTGGCGGTGCTGACTTCCTTCGGACGCCGCTTGTTG
GTGCTGGTGCCGGTGTACCTGGCAGGGGCAGCGGGTCTTAGCGTGGGTTTCGTGCTTTTCGGCC
TCGCCCTCTACCTGGGCTGGCGCCGGGTCCGCGACGGGAAAGAACGGAGCCTGAGGGCAGCGAG
GCAGCTGCTGGATGACGAGGAGCGGATCACGGCAGAAACGCTTTATATGAGCCATCGGGAACTA
CCTGCCTGGGTCAGCTTCCCAGATGTGGAAAAGGCGGAGTGGCTGAATAAGATTGTGGTGCAGG
TATGGCCCTTCCTAGGCCAATATATGGAGAAGCTTCTGGCTGAAACGGTAGCCCCAGCTGTCCG
GGGAGCTAACCCCCATCTGCAAACTTTCACATTTACTCGTGTGGAGCTGGGTGAAAAGCCAGTA
AGAATCATCGGAGTCAAGGTTCACCCTAGTCAGAGAAAAGATCAGATTCTACTGGACTTGAATG
TCAGCTACGTGGGGGACCTACAGATTGATGTGGAAGTTAAAAAATACTTCTGCAAAGCCGGAGT
CAAGGGCATGCAGCTCCACGGTGTCTTGCGGGTGATTCTTGAGCCGCTCATAGGGGACCTTCCT
ATCGTGGGGGCAGTGTCCATGTTCTTCATCAAACGCCCGACACTTGACATCAACTGGACAGGGA
TGACCAACCTGCTGGATATCCCAGGACTTAGCTCACTCTCTGACACGATGATCATGGACTCCAT
TGCTGCCTTCCTTGTGCTCCCTAACCGACTGTTGGTGCCCCTTGTGCCTGACCTTCAAGATGTG
GCCCAGCTGCGGTCCCCACTACCCAGGGGCATTATCCGGATTCACCTGCTGGCAGCCCGAGGTC
TGAGTTCCAAGGACAAGTATGTGAAAGGCCTGATTGAGGGCAAATCGGATCCCTATGCGCTTGT
TCGAGTGGGCACCCAGACATTCTGCAGCCGCGTCATAGATGAGGAGCTCAACCCTCGCTGGGGA
GAGACGTATGAGGTGATAGTCCATGAAGTTCCAGGACAGGAGATCGAGGTGGAGGTATTTGACA
AGGATCCAGATAAAGATGACTTTCTGGGAAGAATGAAGCTGGACGTAGGGAAGGTATTACAGGC
TGGAGTCCTGGATAATTGGTACCCTCTACAAGGTGGGCAAGGCCAAGTTCACTTGAGGTTAGAA
TGGCTATCACTTCTACCAGATGCAGAAAAGCTGGATCAGGTTCTACAGTGGAATCGAGGCATCA
CTTCTCGGCCAGAGCCCCCGTCAGCTGCCATCCTTGTTGTCTACTTGGATCGAGCCCAGGATCT
TCCTCTGAAGAAAGGCAACAAGGAACCCAATCCCATGGTGCAACTGTCAGTTCAGGATGTGACC
CAGGAGAGCAAGGCTACCTACAGCACCAACTGCCCAGTGTGGGAGGAGGCTTTCCGATTCTTCC
TGCAAGACCCTCGAAGCCAGGAGCTTGATGTGCAGGTGAAGGACGACTCCAGGGCCCTGACTTT
AGGGGCCCTGACCCTCCCCCTTGCTCGCCTGTTGACTGCCTCTGAACTCACCCTGGACCAGTGG
TTCCAGCTCAGCAGCTCAGGCCCAAACTCCAGGCTCTACATGAAACTGGTCATGCGGATCCTGT
ACTTAGATTCCTCAGAAATGCGCTTGCCCACTGAGCCTGGTGCCCAGGACTGGGACAGTGAGAG
TCCAGAGACAGGCAGCAGTGTGGATGCCCCACCTCGGCCCTACCACACGACTCCTAACAGCCAC
TTTGGGACTGAGAATGTTCTTCGGATCCATGTATTAGAAGCCCAGGACCTAATTGCCAAAGACC
GTTTCTTGGGGGGGCTGGTTAAGGGCAAATCAGACCCCTACGTCAAACTGAAGGTGGCAGGAAG
AAGTCTCCGGACCCACGTTGTTCGGGAGGATCTCAATCCCCGCTGGAATGAGGTTTTTGAGGTG
ATTGTCACATCAATCCCTGGCCAAGAGCTTGACATTGAGGTCTTTGATAAGGACTTGGACAAGG
ATGACTTTTTGGGCAGGTATAAAGTGGGTCTCACCACAGTGCTCAACAGTGGCTTTCTTGATGA
GTGGCTGACCCTGGAGGATGTCCCATCTGGGCGCCTGCACTTGCGCCTGGAGCGTCTGAGCCCC
AGACCGACTGCTGCTGAGTTAGAGGAGGTGCTGCAGGTGAACAGCCTGATCCAGACCCAGAAGA
GCTCAGAGCTGGCGGCAGCCCTGCTGTCTGTCTACTTGGAGCGCTCAGAAGATCTGCCGCTCCG
AAAAGGAACCAAGCCTCCCAGTCCTTATGCTATTCTAACCGTGGGAGAGACATCCCATAAAACT
AAGACTGTCTCCCAGACTTCAGCCCCCATCTGGGAGGAGAGTGCCTCCTTTCTCATCAGGAAGC
CACATGCTGAGAGCCTGGAGCTGCAGGTTCGGGGTGAAGGGACAGGCACCTTGGGCTCCATATC
CCTGCCTCTCTCTGAGCTCCTCCAGGAAGAGCAACTCTGCCTGGACCGCTGGTTTGCACTCAGC
GGTCAGGGTCAGGTGCTAATGAGAGTGCAGCTAGGGATCCTGGTATCCCAGCATTCAGGAGTGG
AAGCCCACAGCCACAGCTCCTCCTCTCTCAATGAAGAGCCTGAGGTTTTAGGGGACCCCACTCA
CACCGCCTCCCCAGTCTTAGAGGTCAGGCATCGCCTGACACATGGTGACAGTCCCTCTGAGGCT
TTGATTGGGCCCCTGGGCCAGGTGAAGCTGACAGTGTGGTACCACAGTGACGAACAGAAGCTGA
TCAGTATTATTCATAGCTGCCGGGCCCTTCGACAAAATGGACGTGATCTCCCAGACCCCTATGT
GTCAGTGTTGCTGCTCCCAGACAAGAACCGAGGCACCAAGAGGAAGACCTCACAGAAGAAGAGG
ACCCTCAATCCTGAGTTCAATGAGCGGTTTGAATGGGACCTGCCCCTGGATGGGACTCTTAGGA
GGAAGCTCGATGTCTCTGTGAAGTCAAACTCCTCCTTCATGTCAAGAGAGCGTGAGCTTCTGGG
GAAGGTGCAGCTGGATCTAGCAGAGATAGACCTTTCCCAGGGTGCAGCCCAGTGGTACGACCTG
ATAGATGACAGAGACAAGGGCGGTTCCTAAGAGCTGGACTGTGACAGCCTGGCACTGCTGACTT
CTCGCCTTGCCTCATGCCCCTGTGTAATGAGCCTTCACAGCTGGGGCTCCAGGGCTGAGCCTGT
GCCCTTTTGCCTTCTGGGCCCATATAAAGGGTCTTCGCCTGACCAAAGAGGATCACATTGTCCC
CACTACTGCACGGCCTTCCTTGCGCTGCGGGCTCCTAGGGCGGGGCCTGAGCTGGTTATTTCCT
GCCTGCACCTCCTCCTTCCCACTCCTCAGGGCCTCACGCACCGCACCTGTGCCTGGCCGCTGGC
AGCCCTAGCAGTGGCGTAGCTCATGCCAAATACAGCTTCCGGAAAGCCTTTTTTTTTTTTTTTT
TTTACATAATAAAAAAATACACAGAAAACAGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058945	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD10051	(Get FASTA)	NCBI Sequence Viewer
	AAI01858	(Get FASTA)	NCBI Sequence Viewer
	EDL84844	(Get FASTA)	NCBI Sequence Viewer
	Q9Z1X1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_058945 ⟸ NM_017249

- UniProtKB:

Q3T1L3 (UniProtKB/Swiss-Prot), Q9Z1X1 (UniProtKB/Swiss-Prot), A0A0G2JXJ7 (UniProtKB/TrEMBL), A6KSE8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAG
AAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDV
EKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHP
SQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFF
IKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPR
GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPRWGETYEVIVHE
VPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAE
KLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYST
NCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPN
SRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRI
HVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQE
LDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEE
VLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAP
IWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRV
QLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVK
LTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNER
FEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS

hide sequence

RefSeq Acc Id:

ENSRNOP00000070299 ⟸ ENSRNOT00000082107

Protein Domains

C2 SMP-LTD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z1X1-F1-model_v2	AlphaFold	Q9Z1X1	1-1088	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3053	AgrOrtholog
BioCyc Gene	G2FUF-35358	BioCyc
Ensembl Genes	ENSRNOG00000060753	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000070299	ENTREZGENE
	ENSRNOP00000070299.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082107	ENTREZGENE
	ENSRNOT00000082107.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7937926	IMAGE-MGC_LOAD
InterPro	C2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2C_KIAA1228	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ext_Synaptotagmin_C2A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ext_Synaptotagmin_C2B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SMP_LBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Synaptotagmin_SMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29579	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:124625	IMAGE-MGC_LOAD
NCBI Gene	29579	ENTREZGENE
PANTHER	EXTENDED SYNAPTOTAGMIN-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PF00168	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SMP_LBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Esyt1	PhenoGen
PRINTS	C2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PS50004	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00239	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49562	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC219887
UniProt	A0A0G2JXJ7	ENTREZGENE, UniProtKB/TrEMBL
	A6KSE8	ENTREZGENE, UniProtKB/TrEMBL
	ESYT1_RAT	UniProtKB/Swiss-Prot
	Q3T1L3	ENTREZGENE
	Q9Z1X1	ENTREZGENE
UniProt Secondary	Q3T1L3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-22	Esyt1	extended synaptotagmin 1	Esyt1	extended synaptotagmin protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-15	Esyt1	extended synaptotagmin protein 1	Esyt1	extended synaptotagmin-like protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Esyt1	extended synaptotagmin-like protein 1	Fam62a	family with sequence similarity 62 (C2 domain containing), member A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-08	Fam62a	family with sequence similarity 62 (C2 domain containing), member A	Mbc2	membrane bound C2 domain containing protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Mbc2	membrane bound C2 domain containing protein			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains five C2 domains	69883

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar