Esyt1 (extended synaptotagmin 1) - Rat Genome Database

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Gene: Esyt1 (extended synaptotagmin 1) Rattus norvegicus
Analyze
Symbol: Esyt1
Name: extended synaptotagmin 1
RGD ID: 3053
Description: Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Orthologous to human ESYT1 (extended synaptotagmin 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E-Syt1; extended synaptotagmin protein 1; extended synaptotagmin-1; extended synaptotagmin-like protein 1; Fam62a; family with sequence similarity 62 (C2 domain containing), member A; Mbc2; membrane bound C2 domain containing protein; membrane-bound C2 domain-containing protein; MGC124625; vp115
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27928,848 - 946,199 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7928,848 - 946,199 (-)Ensembl
Rnor_6.072,924,216 - 2,941,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,924,603 - 2,941,122 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,897,632 - 2,914,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,790,700 - 1,808,060 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,791,039 - 1,808,005 (-)NCBI
Celera7802,008 - 819,338 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. Morris NJ, etal., Biochim Biophys Acta 1999 May 18;1431(2):525-30.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17110338   PMID:19946888   PMID:22871113   PMID:23791178   PMID:27065097  


Genomics

Comparative Map Data
Esyt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27928,848 - 946,199 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7928,848 - 946,199 (-)Ensembl
Rnor_6.072,924,216 - 2,941,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,924,603 - 2,941,122 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,897,632 - 2,914,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,790,700 - 1,808,060 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,791,039 - 1,808,005 (-)NCBI
Celera7802,008 - 819,338 (-)NCBICelera
Cytogenetic Map7q11NCBI
ESYT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,128,267 - 56,144,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1256,118,250 - 56,144,674 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,522,051 - 56,538,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,808,321 - 54,824,722 (+)NCBINCBI36hg18NCBI36
Celera1256,174,129 - 56,190,606 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,561,123 - 53,577,517 (+)NCBIHuRef
CHM1_11256,489,351 - 56,505,826 (+)NCBICHM1_1
T2T-CHM13v2.01256,095,865 - 56,112,273 (+)NCBI
Esyt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,346,117 - 128,361,728 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,345,834 - 128,361,740 (-)Ensembl
GRCm3810128,510,248 - 128,525,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,509,965 - 128,525,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,947,304 - 127,962,915 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,913,197 - 127,928,808 (-)NCBImm8
Celera10130,902,178 - 130,917,817 (-)NCBICelera
Cytogenetic Map10D3NCBI
Esyt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,733,071 - 3,745,876 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,732,968 - 3,746,856 (+)NCBIChiLan1.0ChiLan1.0
ESYT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,021,770 - 33,037,988 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,021,770 - 33,037,988 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,770,870 - 32,787,352 (-)NCBIMhudiblu_PPA_v0panPan3
ESYT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110448,807 - 462,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10448,881 - 461,332 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10510,556 - 525,658 (+)NCBI
ROS_Cfam_1.010455,687 - 470,823 (+)NCBI
ROS_Cfam_1.0 Ensembl10455,519 - 470,822 (+)Ensembl
UMICH_Zoey_3.110433,143 - 448,267 (+)NCBI
UNSW_CanFamBas_1.010676,264 - 691,357 (+)NCBI
UU_Cfam_GSD_1.010800,278 - 815,384 (+)NCBI
Esyt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,318,429 - 58,333,665 (-)NCBI
SpeTri2.0NW_004936646536,561 - 551,806 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESYT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,514,510 - 21,535,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,517,956 - 21,535,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,986,045 - 23,003,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESYT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,066,624 - 52,085,114 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,068,884 - 52,085,726 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,899,607 - 193,916,061 (-)NCBIVero_WHO_p1.0
Esyt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,863,094 - 11,877,642 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462480211,863,094 - 11,891,632 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH140472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27928,908 - 929,117 (+)MAPPERmRatBN7.2
Rnor_6.072,924,277 - 2,924,485NCBIRnor6.0
Rnor_5.072,897,693 - 2,897,901UniSTSRnor5.0
RGSC_v3.471,790,761 - 1,790,969UniSTSRGSC3.4
Celera7802,069 - 802,277UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:65
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000006119
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 68 35 39 11 8
Low 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082107   ⟹   ENSRNOP00000070299
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7928,848 - 946,199 (-)Ensembl
Rnor_6.0 Ensembl72,924,603 - 2,941,122 (-)Ensembl
RefSeq Acc Id: NM_017249   ⟹   NP_058945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27928,848 - 946,199 (-)NCBI
Rnor_6.072,924,216 - 2,941,213 (-)NCBI
Rnor_5.072,897,632 - 2,914,841 (-)NCBI
RGSC_v3.471,790,700 - 1,808,060 (-)RGD
Celera7802,008 - 819,338 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058945 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD10051 (Get FASTA)   NCBI Sequence Viewer  
  AAI01858 (Get FASTA)   NCBI Sequence Viewer  
  EDL84844 (Get FASTA)   NCBI Sequence Viewer  
  Q9Z1X1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058945   ⟸   NM_017249
- UniProtKB: Q9Z1X1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070299   ⟸   ENSRNOT00000082107
Protein Domains
C2   SMP-LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1X1-F1-model_v2 AlphaFold Q9Z1X1 1-1088 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694940
Promoter ID:EPDNEW_R5465
Type:single initiation site
Name:Esyt1_1
Description:extended synaptotagmin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,941,167 - 2,941,227EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 1804680 1804681 C T snv WKY/N (KNAW), FHH/EurMcwi (MDC)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3053 AgrOrtholog
BioCyc Gene G2FUF-35358 BioCyc
Ensembl Genes ENSRNOG00000060753 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070299 ENTREZGENE
  ENSRNOP00000070299.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082107 ENTREZGENE
  ENSRNOT00000082107.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7937926 IMAGE-MGC_LOAD
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2C_KIAA1228 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ext_Synaptotagmin_C2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ext_Synaptotagmin_C2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin_SMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29579 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124625 IMAGE-MGC_LOAD
NCBI Gene 29579 ENTREZGENE
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Esyt1 PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219887
UniProt A0A0G2JXJ7_RAT UniProtKB/TrEMBL
  ESYT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3T1L3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Esyt1  extended synaptotagmin 1  Esyt1  extended synaptotagmin protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Esyt1  extended synaptotagmin protein 1  Esyt1  extended synaptotagmin-like protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Esyt1  extended synaptotagmin-like protein 1  Fam62a  family with sequence similarity 62 (C2 domain containing), member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-08 Fam62a  family with sequence similarity 62 (C2 domain containing), member A  Mbc2  membrane bound C2 domain containing protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mbc2  membrane bound C2 domain containing protein       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains five C2 domains 69883