Kcnmb1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1) - Rat Genome Database

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Gene: Kcnmb1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1) Rattus norvegicus
Analyze
Symbol: Kcnmb1
Name: potassium calcium-activated channel subfamily M regulatory beta subunit 1
RGD ID: 2961
Description: Exhibits potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to localize to voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; LOC60591; maxi K channel subunit beta-1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta; slo-beta-1; slowpoke-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnmb1em1Mcwi   Kcnmb1em3Mcwi  
Genetic Models: SS-Kcnmb1em3Mcwi SS-Kcnmb1em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21018,557,510 - 18,614,824 (+)NCBI
Rnor_6.0 Ensembl1018,906,010 - 18,919,639 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01018,910,586 - 18,922,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01018,790,595 - 18,800,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,904,902 - 18,912,604 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11018,905,950 - 18,913,652 (+)NCBI
Celera1018,189,045 - 18,196,906 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Amberg GC and Santana LF, Circ Res 2003 Nov 14;93(10):965-71. Epub 2003 Oct 9.
2. Bautista L, etal., Circ Res. 2009 Jun 19;104(12):1364-72. doi: 10.1161/CIRCRESAHA.108.190645. Epub 2009 May 21.
3. Bukiya AN, etal., FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.
4. Bukiya AN, etal., Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.
5. Bukiya AN, etal., Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.
6. Chang CP, etal., Brain Res Mol Brain Res 1997 Apr;45(1):33-40.
7. Chang H, etal., J Cell Physiol. 2011 Jun;226(6):1660-75. doi: 10.1002/jcp.22497.
8. Chang T, etal., Am J Hypertens. 2006 Jul;19(7):678-85.
9. Falk T, etal., Neuroscience 2003;120(2):387-404.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Jiang Z, etal., Genomics 1999 Jan 1;55(1):57-67.
13. Li S, etal., Diabetes Metab Res Rev. 2011 Jul;27(5):461-9. doi: 10.1002/dmrr.1196.
14. Lu T, etal., Biophys J. 2008 Dec;95(11):5165-77. doi: 10.1529/biophysj.108.138339. Epub 2008 Sep 12.
15. MGD data from the GO Consortium
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. RGD comprehensive gene curation
21. Senti M, etal., Circ Res. 2005 Dec 9;97(12):1360-5. Epub 2005 Nov 17.
22. Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
23. Via M, etal., J Hum Genet. 2005;50(11):604-6. Epub 2005 Sep 10.
24. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
Additional References at PubMed
PMID:12388098   PMID:14966080   PMID:16113069   PMID:17209121   PMID:17293477   PMID:19321803   PMID:19940072   PMID:20139169   PMID:20334613   PMID:20443052   PMID:20936291   PMID:21438011  
PMID:22660813   PMID:25371198   PMID:28487419   PMID:29040972   PMID:29093563   PMID:30012867   PMID:31738403   PMID:32967457  


Genomics

Comparative Map Data
Kcnmb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21018,557,510 - 18,614,824 (+)NCBI
Rnor_6.0 Ensembl1018,906,010 - 18,919,639 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01018,910,586 - 18,922,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01018,790,595 - 18,800,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,904,902 - 18,912,604 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11018,905,950 - 18,913,652 (+)NCBI
Celera1018,189,045 - 18,196,906 (+)NCBICelera
Cytogenetic Map10q12NCBI
KCNMB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5170,374,671 - 170,389,634 (-)EnsemblGRCh38hg38GRCh38
GRCh385170,374,671 - 170,389,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375169,801,675 - 169,816,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,737,745 - 169,749,216 (-)NCBINCBI36hg18NCBI36
Build 345169,737,744 - 169,749,216NCBI
Celera5165,837,099 - 165,848,570 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5164,904,047 - 164,915,563 (-)NCBIHuRef
CHM1_15169,238,046 - 169,249,557 (-)NCBICHM1_1
Kcnmb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,912,955 - 33,923,641 (+)NCBIGRCm39mm39
GRCm39 Ensembl1133,913,013 - 33,923,641 (+)Ensembl
GRCm381133,962,955 - 33,973,641 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,963,013 - 33,973,641 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,863,013 - 33,873,638 (+)NCBIGRCm37mm9NCBIm37
MGSCv361133,863,286 - 33,871,275 (+)NCBImm8
Celera1136,374,009 - 36,384,630 (+)NCBICelera
Cytogenetic Map11A4NCBI
Kcnmb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540823,325,225 - 23,335,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540823,306,286 - 23,335,170 (-)NCBIChiLan1.0ChiLan1.0
KCNMB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15172,495,762 - 172,507,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5172,495,762 - 172,507,318 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05165,712,588 - 165,747,948 (-)NCBIMhudiblu_PPA_v0panPan3
KCNMB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,536,841 - 41,545,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,537,225 - 41,545,344 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,491,752 - 41,497,517 (+)NCBI
ROS_Cfam_1.0441,912,957 - 41,922,108 (+)NCBI
UMICH_Zoey_3.1441,733,152 - 41,738,919 (+)NCBI
UNSW_CanFamBas_1.0441,919,686 - 41,925,451 (+)NCBI
UU_Cfam_GSD_1.0442,430,404 - 42,436,172 (+)NCBI
Kcnmb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721395,728,790 - 95,736,033 (+)NCBI
SpeTri2.0NW_0049366094,451,526 - 4,458,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,618,603 - 53,631,197 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,616,532 - 53,631,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21657,959,628 - 57,972,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,580,617 - 72,591,070 (-)NCBI
ChlSab1.1 Ensembl2372,577,813 - 72,591,588 (-)Ensembl
Vero_WHO_p1.0NW_0236660346,070,733 - 6,081,816 (+)NCBI
Kcnmb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473319,582,646 - 19,593,581 (+)NCBI

Position Markers
RH142383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,565,193 - 18,565,369 (+)MAPPER
Rnor_6.01018,919,035 - 18,919,210NCBIRnor6.0
Rnor_5.01018,797,692 - 18,797,867UniSTSRnor5.0
RGSC_v3.41018,911,999 - 18,912,174UniSTSRGSC3.4
Celera1018,196,301 - 18,196,476UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101755538619743866Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101824639453637634Rat


Genetic Models
This gene Kcnmb1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:155
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000007393, ENSRNOT00000007408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6
Low 2 35 2 4 2 2 1 28 18 11 2
Below cutoff 8 17 4 15 4 6 7 52 7 16 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007393   ⟹   ENSRNOP00000007393
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,912,865 - 18,919,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000007408   ⟹   ENSRNOP00000007408
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,911,938 - 18,919,639 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090659   ⟹   ENSRNOP00000071161
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,906,010 - 18,919,261 (+)Ensembl
RefSeq Acc Id: NM_019273   ⟹   NP_062146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,557,904 - 18,565,799 (+)NCBI
Rnor_6.01018,911,938 - 18,919,640 (+)NCBI
Rnor_5.01018,790,595 - 18,800,957 (+)NCBI
RGSC_v3.41018,904,902 - 18,912,604 (+)RGD
Celera1018,189,045 - 18,196,906 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246089   ⟹   XP_006246151
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,558,206 - 18,569,015 (+)NCBI
Rnor_6.01018,910,586 - 18,922,856 (+)NCBI
Rnor_5.01018,790,595 - 18,800,957 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767563   ⟹   XP_008765785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01018,910,587 - 18,922,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767564   ⟹   XP_008765786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01018,910,586 - 18,922,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085796   ⟹   XP_038941724
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,557,510 - 18,614,824 (+)NCBI
RefSeq Acc Id: XM_039085797   ⟹   XP_038941725
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,557,519 - 18,569,015 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062146   ⟸   NM_019273
- UniProtKB: P97678 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246151   ⟸   XM_006246089
- Peptide Label: isoform X1
- UniProtKB: P97678 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765786   ⟸   XM_008767564
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008765785   ⟸   XM_008767563
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071161   ⟸   ENSRNOT00000090659
RefSeq Acc Id: ENSRNOP00000007408   ⟸   ENSRNOT00000007408
RefSeq Acc Id: ENSRNOP00000007393   ⟸   ENSRNOT00000007393
RefSeq Acc Id: XP_038941724   ⟸   XM_039085796
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941725   ⟸   XM_039085797
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697097
Promoter ID:EPDNEW_R7622
Type:initiation region
Name:Kcnmb1_1
Description:potassium calcium-activated channel subfamily M regulatory betasubunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01018,912,187 - 18,912,247EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2961 AgrOrtholog
Ensembl Genes ENSRNOG00000005465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007393 UniProtKB/Swiss-Prot
  ENSRNOP00000007408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071161 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007393 UniProtKB/Swiss-Prot
  ENSRNOT00000007408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000090659 UniProtKB/Swiss-Prot
InterPro K_chnl_Ca-activ_BK_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29747 UniProtKB/Swiss-Prot
NCBI Gene 29747 ENTREZGENE
PANTHER PTHR10258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnmb1 PhenoGen
PRINTS BKCHANNELB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5U130_RAT UniProtKB/TrEMBL
  KCMB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O35337 UniProtKB/Swiss-Prot
  O88805 UniProtKB/Swiss-Prot
  Q9ESK7 UniProtKB/Swiss-Prot
  Q9QWI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-26 Kcnmb1  potassium large conductance calcium-activated channel, subfamily M, beta member 1  LOC60591  calcium-activated potassium channel beta subunit  Data Merged 737654 APPROVED
2002-06-10 Kcnmb1  potassium large conductance calcium-activated channel, subfamily M, beta member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease expression is decreased during hypertension 1298970
gene_expression expressed in a few discrete populations of neurons 1298969
gene_process modulates the channel activity 1298969