Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2) - Rat Genome Database

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Gene: Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2) Rattus norvegicus
Analyze
Symbol: Gucy1b2
Name: guanylate cyclase 1 soluble subunit beta 2
RGD ID: 2770
Description: Enables ion binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GCS-beta-2; guanylate cyclase 1 soluble beta 2; guanylate cyclase 1, soluble, beta 2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit beta-2; guanylate cyclase, soluble, beta 2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); Gucy1b2a; Gucy1b2b; SGC; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21536,589,501 - 36,669,441 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1536,598,883 - 36,669,441 (-)Ensembl
Rnor_6.01545,479,662 - 45,550,285 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,479,658 - 45,550,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,255,071 - 49,325,713 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,620,373 - 41,668,802 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11541,636,072 - 41,684,502 (-)NCBI
Celera1536,296,636 - 36,358,650 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat. Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
2. The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney. Behrends S, etal., Naunyn Schmiedebergs Arch Pharmacol 2001 Dec;364(6):573-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Nitric oxide activates the beta 2 subunit of soluble guanylyl cyclase in the absence of a second subunit. Koglin M, etal., J Biol Chem 2001 Aug 17;276(33):30737-43. Epub 2001 Jun 13.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
11. A new form of guanylyl cyclase is preferentially expressed in rat kidney. Yuen PS, etal., Biochemistry 1990 Dec 11;29(49):10872-8.
Additional References at PubMed
PMID:20623   PMID:1298938   PMID:14687925   PMID:15652699   PMID:16331987  


Genomics

Comparative Map Data
Gucy1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21536,589,501 - 36,669,441 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1536,598,883 - 36,669,441 (-)Ensembl
Rnor_6.01545,479,662 - 45,550,285 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,479,658 - 45,550,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,255,071 - 49,325,713 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,620,373 - 41,668,802 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11541,636,072 - 41,684,502 (-)NCBI
Celera1536,296,636 - 36,358,650 (-)NCBICelera
Cytogenetic Map15p12NCBI
GUCY1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,994,511 - 51,066,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1350,994,511 - 51,080,862 (-)EnsemblGRCh38hg38GRCh38
GRCh371351,568,647 - 51,640,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,466,770 - 50,538,143 (-)NCBINCBI36hg18NCBI36
Build 341350,466,648 - 50,538,143NCBI
Celera1332,617,656 - 32,689,305 (-)NCBI
Cytogenetic Map13q14.3NCBI
HuRef1332,357,567 - 32,429,119 (-)NCBIHuRef
CHM1_11351,535,852 - 51,607,823 (-)NCBICHM1_1
T2T-CHM13v2.01350,209,471 - 50,281,130 (-)NCBI
Gucy1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,610,384 - 62,693,745 (-)NCBIGRCm39mm39
GRCm39 Ensembl1462,630,125 - 62,693,738 (-)Ensembl
GRCm381462,372,935 - 62,456,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,392,676 - 62,456,289 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,011,513 - 63,075,126 (-)NCBIGRCm37mm9NCBIm37
MGSCv361461,346,786 - 61,410,399 (-)NCBImm8
Celera1460,167,130 - 60,218,922 (-)NCBICelera
Cytogenetic Map14D1NCBI
LOC485435
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122912,345 - 922,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22944,177 - 948,277 (+)NCBI
ROS_Cfam_1.022893,270 - 897,370 (+)NCBI
UMICH_Zoey_3.122814,253 - 818,352 (+)NCBI
UNSW_CanFamBas_1.022863,454 - 867,552 (+)NCBI
UU_Cfam_GSD_1.022881,784 - 885,883 (+)NCBI
LOC100625149
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11116,772,313 - 16,811,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:36
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 30 23 7 23 8
Low 2 18 16 10 16 31 11 3 5
Below cutoff 24 9 2 2 2 5 5 26 10 17 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB114835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY004153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012948   ⟹   ENSRNOP00000012948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,606,870 - 36,669,441 (-)Ensembl
Rnor_6.0 Ensembl1545,487,645 - 45,550,285 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081912   ⟹   ENSRNOP00000071659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,598,883 - 36,643,807 (-)Ensembl
Rnor_6.0 Ensembl1545,479,658 - 45,524,582 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087678   ⟹   ENSRNOP00000073161
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,606,870 - 36,664,889 (-)Ensembl
Rnor_6.0 Ensembl1545,487,573 - 45,545,875 (-)Ensembl
RefSeq Acc Id: NM_001270711   ⟹   NP_001257640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,606,854 - 36,669,441 (-)NCBI
Rnor_6.01545,487,629 - 45,550,285 (-)NCBI
Rnor_5.01549,255,071 - 49,325,713 (-)NCBI
Celera1536,296,636 - 36,358,650 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012770   ⟹   NP_036902
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,606,854 - 36,655,285 (-)NCBI
Rnor_6.01545,487,629 - 45,536,058 (-)NCBI
Rnor_5.01549,255,071 - 49,325,713 (-)NCBI
RGSC_v3.41541,620,373 - 41,668,802 (-)RGD
Celera1536,296,636 - 36,345,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770741   ⟹   XP_008768963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,598,884 - 36,655,498 (-)NCBI
Rnor_6.01545,479,662 - 45,545,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093002   ⟹   XP_038948930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,589,501 - 36,656,021 (-)NCBI
RefSeq Acc Id: XM_039093003   ⟹   XP_038948931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,628,103 - 36,656,021 (-)NCBI
RefSeq Acc Id: XR_005493692
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21536,624,913 - 36,656,019 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036902   ⟸   NM_012770
- Peptide Label: isoform 2
- UniProtKB: P22717 (UniProtKB/Swiss-Prot),   A0A0G2K4T2 (UniProtKB/TrEMBL),   Q80WX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257640   ⟸   NM_001270711
- Peptide Label: isoform 1
- UniProtKB: P22717 (UniProtKB/Swiss-Prot),   A0A0G2QC51 (UniProtKB/TrEMBL),   Q80WX7 (UniProtKB/TrEMBL),   Q91XJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768963   ⟸   XM_008770741
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000073161   ⟸   ENSRNOT00000087678
RefSeq Acc Id: ENSRNOP00000071659   ⟸   ENSRNOT00000081912
RefSeq Acc Id: ENSRNOP00000012948   ⟸   ENSRNOT00000012948
RefSeq Acc Id: XP_038948930   ⟸   XM_039093002
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948931   ⟸   XM_039093003
- Peptide Label: isoform X3
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22717-F1-model_v2 AlphaFold P22717 1-682 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 45520671 45520672 G A snv MR/N (2020)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 49263213 49263214 G T snv DOB/Oda (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2770 AgrOrtholog
BioCyc Gene G2FUF-13462 BioCyc
Ensembl Genes ENSRNOG00000009440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012948 ENTREZGENE
  ENSRNOP00000012948.4 UniProtKB/TrEMBL
  ENSRNOP00000071659 ENTREZGENE
  ENSRNOP00000071659.1 UniProtKB/TrEMBL
  ENSRNOP00000073161.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012948 ENTREZGENE
  ENSRNOT00000012948.6 UniProtKB/TrEMBL
  ENSRNOT00000081912 ENTREZGENE
  ENSRNOT00000081912.2 UniProtKB/TrEMBL
  ENSRNOT00000087678.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H-NOX_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heme_NO-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25206 ENTREZGENE
Pfam Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gucy1b2 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2QC51 ENTREZGENE, UniProtKB/TrEMBL
  GCYB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80WX7 ENTREZGENE, UniProtKB/TrEMBL
  Q91XJ7 ENTREZGENE, UniProtKB/TrEMBL
  Q920Q1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Gucy1b2  guanylate cyclase 1 soluble subunit beta 2  Gucy1b2  guanylate cyclase 1, soluble, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gucy1b2  guanylate cyclase 1, soluble, beta 2    guanylate cyclase, soluble, beta 2  Name updated 1299863 APPROVED
2003-04-09 Gucy1b2  guanylate cyclase, soluble, beta 2    guanylate cyclase 1, soluble, beta 2  Name updated 629478 APPROVED
2002-06-10 Gucy1b2  guanylate cyclase 1, soluble, beta 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation 61495
gene_expression expressed at higher levels in kidney and liver than Gucy1b1 61495
gene_process maybe involved in the regulation of blood pressure 61495
gene_process may control salt-sensitive hypertension 61495