Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2)

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Gene: Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2) Rattus norvegicus

Analyze

Symbol:

Gucy1b2

Name:

guanylate cyclase 1 soluble subunit beta 2

RGD ID:

2770

Description:

Enables ion binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GCS-beta-2; guanylate cyclase 1 soluble beta 2; guanylate cyclase 1, soluble, beta 2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit beta-2; guanylate cyclase, soluble, beta 2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); Gucy1b2a; Gucy1b2b; SGC; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b

RGD Orthologs

Human

Mouse

Dog

Pig

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene))	HGNC	Inparanoid, Panther
Mus musculus (house mouse):	Gucy1b2 (guanylate cyclase 1, soluble, beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC485435 (guanylate cyclase soluble subunit beta-2-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100625149 (guanylate cyclase soluble subunit beta-2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene))	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gucy1b2 (guanylate cyclase 1, soluble, beta 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gucy1b2 (guanylate cyclase 1, soluble, beta 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-32	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-34	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-35	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-36	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-37	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gucy1b2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	36,589,501 - 36,669,441 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	36,598,883 - 36,669,441 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	38,483,209 - 38,545,791 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	39,633,844 - 39,696,424 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	38,067,533 - 38,130,118 (-)	NCBI	Rnor_WKY
Rnor_6.0	15	45,479,662 - 45,550,285 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	45,479,658 - 45,550,285 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	49,255,071 - 49,325,713 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	41,620,373 - 41,668,802 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	41,636,072 - 41,684,502 (-)	NCBI
Celera	15	36,296,636 - 36,358,650 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

carmustine (EXP)

copper atom (EXP)

copper(0) (EXP)

decabromodiphenyl ether (EXP)

endosulfan (EXP)

fenvalerate (EXP)

fipronil (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

methotrexate (EXP)

nefazodone (EXP)

ochratoxin A (EXP)

ozone (EXP)

paracetamol (EXP)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP)

rotenone (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

streptozocin (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

tioguanine (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cGMP biosynthetic process (IEA)

cGMP-mediated signaling (IBA)

intracellular signal transduction (IEA)

response to oxygen levels (IBA)

Cellular Component

cytoplasm (IEA)

cytosol (TAS)

guanylate cyclase complex, soluble (IBA)

Molecular Function

GTP binding (IEA)

guanylate cyclase activity (IBA,IEA)

heme binding (IEA)

ion binding (IDA)

metal ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

long term depression (IEA)

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat.	Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
2.	The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney.	Behrends S, etal., Naunyn Schmiedebergs Arch Pharmacol 2001 Dec;364(6):573-6.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Nitric oxide activates the beta 2 subunit of soluble guanylyl cyclase in the absence of a second subunit.	Koglin M, etal., J Biol Chem 2001 Aug 17;276(33):30737-43. Epub 2001 Jun 13.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.	Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
11.	A new form of guanylyl cyclase is preferentially expressed in rat kidney.	Yuen PS, etal., Biochemistry 1990 Dec 11;29(49):10872-8.

Additional References at PubMed

PMID:20623	PMID:1298938	PMID:14687925	PMID:15652699	PMID:16331987

Genomics

Comparative Map Data

Gucy1b2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	36,589,501 - 36,669,441 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	36,598,883 - 36,669,441 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	38,483,209 - 38,545,791 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	39,633,844 - 39,696,424 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	38,067,533 - 38,130,118 (-)	NCBI	Rnor_WKY
Rnor_6.0	15	45,479,662 - 45,550,285 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	45,479,658 - 45,550,285 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	49,255,071 - 49,325,713 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	41,620,373 - 41,668,802 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	41,636,072 - 41,684,502 (-)	NCBI
Celera	15	36,296,636 - 36,358,650 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

GUCY1B2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	50,994,511 - 51,066,157 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	13	50,994,511 - 51,080,862 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	51,568,647 - 51,640,293 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	50,466,770 - 50,538,143 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	50,466,648 - 50,538,143	NCBI
Celera	13	32,617,656 - 32,689,305 (-)	NCBI		Celera
Cytogenetic Map	13	q14.3	NCBI
HuRef	13	32,357,567 - 32,429,119 (-)	NCBI		HuRef
CHM1_1	13	51,535,852 - 51,607,823 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	50,209,471 - 50,281,130 (-)	NCBI		T2T-CHM13v2.0

Gucy1b2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	62,610,384 - 62,693,745 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	62,630,125 - 62,693,738 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	62,372,935 - 62,456,291 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	62,392,676 - 62,456,289 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	63,011,513 - 63,075,126 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	61,346,786 - 61,410,399 (-)	NCBI		MGSCv36	mm8
Celera	14	60,167,130 - 60,218,922 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI

LOC485435
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	912,345 - 922,334 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	944,177 - 948,277 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	893,270 - 897,370 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	22	814,253 - 818,352 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	863,454 - 867,552 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	881,784 - 885,883 (+)	NCBI		UU_Cfam_GSD_1.0

LOC100625149
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	11	16,772,313 - 16,811,787 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Variants

Variants in Gucy1b2
360 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	36
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000012948
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			30	23	7	23				8
Low	2		18	16	10	16			31	11	3	5
Below cutoff		24	9	2	2	2	5	5	26	10	17	6	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005493692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB058888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB109448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB109449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB109450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB109451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB114835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC133824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF352566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY004153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M57507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012948 ⟹ ENSRNOP00000012948

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	36,606,870 - 36,669,441 (-)	Ensembl
Rnor_6.0 Ensembl	15	45,487,645 - 45,550,285 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081912 ⟹ ENSRNOP00000071659

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	36,598,883 - 36,643,807 (-)	Ensembl
Rnor_6.0 Ensembl	15	45,479,658 - 45,524,582 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087678 ⟹ ENSRNOP00000073161

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	36,606,870 - 36,664,889 (-)	Ensembl
Rnor_6.0 Ensembl	15	45,487,573 - 45,545,875 (-)	Ensembl

RefSeq Acc Id:

NM_001270711 ⟹ NP_001257640

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,606,854 - 36,669,441 (-)	NCBI
Rnor_6.0	15	45,487,629 - 45,550,285 (-)	NCBI
Rnor_5.0	15	49,255,071 - 49,325,713 (-)	NCBI
Celera	15	36,296,636 - 36,358,650 (-)	NCBI

Sequence:

show sequence

CTCGGTTGCTACAAGTCCACATCCAGAGACTTGGCAAGAAACTTGCTGTGCGGCTCCAGCCTGG
AGACACATCGCTGGACACCATGTATGGATTCATCAACACCTGCCTGCAGTCTCTTGTGACAGAG
AAATTTGGTGAGGAGACATGGGAGAAGCTGAAGGCTTCTGCAGAAGTGCAAGATGTCTTCATGA
CCTACACCGTGTATGATGACATCATCACCATTAAGCTCATCCAAGAAGCCTGCAAGGTTCTGGA
TGTGTCCATGGAAGCCATTCTGAAGCTCTTTGGCGAATACTTCTTTAAGTTCTGTAAGATGTCT
GGCTATGACAGGATGCTGCGGACACTTGGAGGAAATCTCACCGAGTTTATTGAAAACCTAGATG
CACTCCACAGTTACCTGGCACTGTCCTATCAGGAAATGAACGCACCATCCTTTCGAGTGGAGGA
AGGAGCTGACGGGGCGATGCTTCTCCACTACTACTCAGACAGACATGGTCTGTGTCACATTGTA
CCAGGTATCATTGAAGCTGTGGCCAAGGACTTCTTTGACACTGATGTGGCCATGAGTATCCTGG
ATATGAACGAAGAGGTGGAAAGGACAGGGAAGAAAGAACATGTTGTGTTTCTGGTCGTGCAGAA
GGCTCACAGACAGATAAGAGGAGCAAAGGCAAGCCGGCCACAAGGCAGTGAGGACAGCCAGGCA
GACCAGGAGGCTCTCCAGGGAACACTCCTTCGGATGAAGGAGAGATATTTAAACATCCCTGTTT
GCCCTGGGGAGAAATCTCACTCAACTGCTGTGAGGGCATCGGTCCTTTTTGGAAAAGGGCCCCT
CAGGGACACCTTCCAGCCCGTCTATCCTGAGAGACTATGGGTCGAAGAGGAGGTGTTCTGTGAT
GCTTTTCCTTTCCACATTGTCTTTGATGAAGCACTAAGGGTCAAGCAAGCTGGAGTGAATATTC
AGAAGTATGTCCCTGGAATCTTAACCCAGAAGTTTGCACTAGATGAGTATTTTTCCATCATCCA
CCCTCAAGTTACTTTCAACATCTCCAGCATCTGCAAGTTCATTAACAGTCAGTTTGTCTTGAAG
ACAAGAAAAGAAATGATGCCCAAAGCAAGGAAGAGCCAGCCGATGCTCAAACTCCGGGGTCAGA
TGATCTGGATGGAGTCTCTGAGGTGCATGATCTTCATGTGTTCCCCAAAGCTCCGCAGCCTGCA
AGAGCTGGAAGAGAGCAAGATGCATCTTTCTGATATCGCTCCGCACGACACGACCAGGGATCTC
ATCCTCCTCAACCAGCAGAGGCTGGCAGAGATGGAGCTGTCCTGCCAACTGGAAAAGAAGAAGG
AGGAGTTGCGTGTCCTTTCCAATCACCTGGCCATCGAGAAGAAGAAGACAGAGACCTTGCTGTA
TGCCATGCTGCCTGAACATGTGGCCAACCAACTCAAGGAGGGCAGAAAGGTGGCTGCAGGAGAA
TTTGAAACATGTACAATCCTTTTCAGCGATGTTGTGACATTTACCAACATCTGTGCAGCCTGTG
AACCTATCCAAATCGTGAACATGCTGAATTCAATGTACTCCAAGTTTGACAGGTTAACCAGTGT
CCATGATGTCTACAAAGTAGAAACAATAGGGGATGCTTACATGGTGGTGGGTGGAGTACCAGTA
CCCGTTGAAAGCCATGCTCAAAGAGTCGCCAATTTTGCTCTGGGGATGAGAATTTCTGCAAAAG
AAGTGATGAATCCTGTCACTGGGGAACCTATCCAGATCAGAGTGGGAATCCACACTGGACCAGT
CTTAGCAGGTGTTGTGGGAGACAAGATGCCTCGGTACTGCTTGTTTGGTGACACTGTAAACACA
GCCTCTAGGATGGAAAGTCACGGGCTTCCCAGCAAAGTGCATCTGAGCCCCACAGCCCACAGAG
CCCTGAAAAACAAAGGGTTTGAAATTGTCAGGAGAGGCGAGATCGAAGTGAAGGGGAAAGGAAA
GATGACCACATACTTTCTGATCCAGAACCTGAATGCCACCGAGGATGAGATAATGGGGCGACCT
TCAGCCCCCGCTGATGGGAAGGAAGTATGTACTCCCGGAAACCAAGTCAGGAAGTCCCCTGCTG
TCCCGAGGAACACAGACCATCAGCAACAAGTCTACAAAGGAGACCCAGCAGACGCTTCTAATGA
AGTCACACTTGCTGGGAGCCCAGTGGCAGGGCGAAACTCCACAGATGCAGTCAATAACCAGCCA
TCACCAGATGAGACCAAGACAAGTGTCGTTGCTAGTGGCCCTGTGCTGTCTGCTTTCTGTGTTG
TGCTGTGATCACGAGAAAAAGTGATCCTATGGGATCCATTTCCTGTATTCCATGGCAGCAAAGG
GAATTAATTTATAAAAATGCTTAAGTTCAAAATGTTTTTGTTTCCATATCTCCCTTGGGGCCCC
TTTGAGAATAAAAAAATTAG

hide sequence

RefSeq Acc Id:

NM_012770 ⟹ NP_036902

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,606,854 - 36,655,285 (-)	NCBI
Rnor_6.0	15	45,487,629 - 45,536,058 (-)	NCBI
Rnor_5.0	15	49,255,071 - 49,325,713 (-)	NCBI
RGSC_v3.4	15	41,620,373 - 41,668,802 (-)	RGD
Celera	15	36,296,636 - 36,345,017 (-)	NCBI

Sequence:

show sequence

CTCCAGTGGCTGAGTGATCAACTATACTCGATGTATCTTCCAGGGCTTCTGCAGAAGTGCAAGA
TGTCTTCATGACCTACACCGTGTATGATGACATCATCACCATTAAGCTCATCCAAGAAGCCTGC
AAGGTTCTGGATGTGTCCATGGAAGCCATTCTGAAGCTCTTTGGCGAATACTTCTTTAAGTTCT
GTAAGATGTCTGGCTATGACAGGATGCTGCGGACACTTGGAGGAAATCTCACCGAGTTTATTGA
AAACCTAGATGCACTCCACAGTTACCTGGCACTGTCCTATCAGGAAATGAACGCACCATCCTTT
CGAGTGGAGGAAGGAGCTGACGGGGCGATGCTTCTCCACTACTACTCAGACAGACATGGTCTGT
GTCACATTGTACCAGGTATCATTGAAGCTGTGGCCAAGGACTTCTTTGACACTGATGTGGCCAT
GAGTATCCTGGATATGAACGAAGAGGTGGAAAGGACAGGGAAGAAAGAACATGTTGTGTTTCTG
GTCGTGCAGAAGGCTCACAGACAGATAAGAGGAGCAAAGGCAAGCCGGCCACAAGGCAGTGAGG
ACAGCCAGGCAGACCAGGAGGCTCTCCAGGGAACACTCCTTCGGATGAAGGAGAGATATTTAAA
CATCCCTGTTTGCCCTGGGGAGAAATCTCACTCAACTGCTGTGAGGGCATCGGTCCTTTTTGGA
AAAGGGCCCCTCAGGGACACCTTCCAGCCCGTCTATCCTGAGAGACTATGGGTCGAAGAGGAGG
TGTTCTGTGATGCTTTTCCTTTCCACATTGTCTTTGATGAAGCACTAAGGGTCAAGCAAGCTGG
AGTGAATATTCAGAAGTATGTCCCTGGAATCTTAACCCAGAAGTTTGCACTAGATGAGTATTTT
TCCATCATCCACCCTCAAGTTACTTTCAACATCTCCAGCATCTGCAAGTTCATTAACAGTCAGT
TTGTCTTGAAGACAAGAAAAGAAATGATGCCCAAAGCAAGGAAGAGCCAGCCGATGCTCAAACT
CCGGGGTCAGATGATCTGGATGGAGTCTCTGAGGTGCATGATCTTCATGTGTTCCCCAAAGCTC
CGCAGCCTGCAAGAGCTGGAAGAGAGCAAGATGCATCTTTCTGATATCGCTCCGCACGACACGA
CCAGGGATCTCATCCTCCTCAACCAGCAGAGGCTGGCAGAGATGGAGCTGTCCTGCCAACTGGA
AAAGAAGAAGGAGGAGTTGCGTGTCCTTTCCAATCACCTGGCCATCGAGAAGAAGAAGACAGAG
ACCTTGCTGTATGCCATGCTGCCTGAACATGTGGCCAACCAACTCAAGGAGGGCAGAAAGGTGG
CTGCAGGAGAATTTGAAACATGTACAATCCTTTTCAGCGATGTTGTGACATTTACCAACATCTG
TGCAGCCTGTGAACCTATCCAAATCGTGAACATGCTGAATTCAATGTACTCCAAGTTTGACAGG
TTAACCAGTGTCCATGATGTCTACAAAGTAGAAACAATAGGGGATGCTTACATGGTGGTGGGTG
GAGTACCAGTACCCGTTGAAAGCCATGCTCAAAGAGTCGCCAATTTTGCTCTGGGGATGAGAAT
TTCTGCAAAAGAAGTGATGAATCCTGTCACTGGGGAACCTATCCAGATCAGAGTGGGAATCCAC
ACTGGACCAGTCTTAGCAGGTGTTGTGGGAGACAAGATGCCTCGGTACTGCTTGTTTGGTGACA
CTGTAAACACAGCCTCTAGGATGGAAAGTCACGGGCTTCCCAGCAAAGTGCATCTGAGCCCCAC
AGCCCACAGAGCCCTGAAAAACAAAGGGTTTGAAATTGTCAGGAGAGGCGAGATCGAAGTGAAG
GGGAAAGGAAAGATGACCACATACTTTCTGATCCAGAACCTGAATGCCACCGAGGATGAGATAA
TGGGGCGACCTTCAGCCCCCGCTGATGGGAAGGAAGTATGTACTCCCGGAAACCAAGTCAGGAA
GTCCCCTGCTGTCCCGAGGAACACAGACCATCAGCAACAAGTCTACAAAGGAGACCCAGCAGAC
GCTTCTAATGAAGTCACACTTGCTGGGAGCCCAGTGGCAGGGCGAAACTCCACAGATGCAGTCA
ATAACCAGCCATCACCAGATGAGACCAAGACAAGTGTCGTTGCTAGTGGCCCTGTGCTGTCTGC
TTTCTGTGTTGTGCTGTGATCACGAGAAAAAGTGATCCTATGGGATCCATTTCCTGTATTCCAT
GGCAGCAAAGGGAATTAATTTATAAAAATGCTTAAGTTCAAAATGTTTTTGTTTCCATATCTCC
CTTGGGGCCCCTTTGAGAATAAAAAAATTAG

hide sequence

RefSeq Acc Id:

XM_008770741 ⟹ XP_008768963

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,598,884 - 36,655,498 (-)	NCBI
Rnor_6.0	15	45,479,662 - 45,545,932 (-)	NCBI

Sequence:

show sequence

GTCCAGATATATGCAGTCAACTTCCAGCCAGACAGTGAGAAATAAAAAGATCCTTCGCTTTTGG
TAGAAAACTTCTAGAACTCAGGTCATTTGGCCTGAATTCATGCCTGGGGTAGGGGCCCAGGAGT
TGAGGAGGGTAGTGTGGCTGAATGCATTGGGCATAACTGAGCACTAAAGAGAGGTGCTTAGGAG
CCCTTCCTCCAGCTCTGCTGGAGCAAAGAAGACAACAGAGGAGGAGGGAGCCTATTGGAAACTT
CTCCCTGTTTCTCTGTGTTATCTTTTGGGGAGTGAGACTTGGGGTAGAGTCAGGTTCACCCTTC
CAGTGTTATCCTTTTCTCTCCTTCTCTTCCTTCTCTCCCTCCTCCATCTCCTCTTCTCTTTCTT
CATTCCAGTGAGGGAACCCAGGCTTTTGCACAGACCAGGCAAGTGCTCAAACACTGAGCCATAC
CTCTGCTCGTCTTCCTCAGTCTGTACTGTTGGTTCCTTTTTCCTCCGCTGTTTGCTTCCTGAAC
ACATACCCTGACCTAGATTCATTTTTATAAAGAAAACAATGTGTCTTTTCACTTCTCTTTGGAA
CCTGTATGGATTCATCAACACCTGCCTGCAGTCTCTTGTGACAGAGAAATTTGGTGAGGAGACA
TGGGAGAAGCTGAAGGCTTCTGCAGAAGTGCAAGATGTCTTCATGACCTACACCGTGTATGATG
ACATCATCACCATTAAGCTCATCCAAGAAGCCTGCAAGGTTCTGGATGTGTCCATGGAAGCCAT
TCTGAAGCTCTTTGGCGAATACTTCTTTAAGTTCTGTAAGATGTCTGGCTATGACAGGATGCTG
CGGACACTTGGAGGAAATCTCACCGAGTTTATTGAAAACCTAGATGCACTCCACAGTTACCTGG
CACTGTCCTATCAGGAAATGAACGCACCATCCTTTCGAGTGGAGGAAGGAGCTGACGGGGCGAT
GCTTCTCCACTACTACTCAGACAGACATGGTCTGTGTCACATTGTACCAGGTATCATTGAAGCT
GTGGCCAAGGACTTCTTTGACACTGATGTGGCCATGAGTATCCTGGATATGAACGAAGAGGTGG
AAAGGACAGGGAAGAAAGAACATGTTGTGTTTCTGGTCGTGCAGAAGGCTCACAGACAGATAAG
AGGAGCAAAGGCAAGCCGGCCACAAGGCAGTGAGGACAGCCAGGCAGACCAGGAGGCTCTCCAG
GGAACACTCCTTCGGATGAAGGAGAGATATTTAAACATCCCTGTTTGCCCTGGGGAGAAATCTC
ACTCAACTGCTGTGAGGGCATCGGTCCTTTTTGGAAAAGGGCCCCTCAGGGACACCTTCCAGCC
CGTCTATCCTGAGAGACTATGGGTCGAAGAGGAGGTGTTCTGTGATGCTTTTCCTTTCCACATT
GTCTTTGATGAAGCACTAAGGGTCAAGCAAGCTGGAGTGAATATTCAGAAGTATGTCCCTGGAA
TCTTAACCCAGAAGTTTGCACTAGATGAGTATTTTTCCATCATCCACCCTCAAGTTACTTTCAA
CATCTCCAGCATCTGCAAGTTCATTAACAGTCAGTTTGTCTTGAAGACAAGAAAAGAAATGATG
CCCAAAGCAAGGAAGAGCCAGCCGATGCTCAAACTCCGGGGTCAGATGATCTGGATGGAGTCTC
TGAGGTGCATGATCTTCATGTGTTCCCCAAAGCTCCGCAGCCTGCAAGAGCTGGAAGAGAGCAA
GATGCATCTTTCTGATATCGCTCCGCACGACACGACCAGGGATCTCATCCTCCTCAACCAGCAG
AGGCTGGCAGAGATGGAGCTGTCCTGCCAACTGGAAAAGAAGAAGGAGGAGTTGCGTGTCCTTT
CCAATCACCTGGCCATCGAGAAGAAGAAGACAGAGACCTTGCTGTATGCCATGCTGCCTGAACA
TGTGGCCAACCAACTCAAGGAGGGCAGAAAGGTGGCTGCAGGAGAATTTGAAACATGTACAATC
CTTTTCAGCGATGTTGTGACATTTACCAACATCTGTGCAGCCTGTGAACCTATCCAAATCGTGA
ACATGCTGAATTCAATGTACTCCAAGTTTGACAGGTTAACCAGTGTCCATGATGTCTACAAAGT
AGAAACAATAGGGGATGCTTACATGGTGGTGGGTGGAGTACCAGTACCCGTTGAAAGCCATGCT
CAAAGAGTCGCCAATTTTGCTCTGGGGATGAGAATTTCTGCAAAAGAAGTGATGAATCCTGTCA
CTGGGGAACCTATCCAGATCAGAGTGGGAATCCACACTGGACCAGTCTTAGCAGGTGTTGTGGG
AGACAAGATGCCTCGGTACTGCTTGTTTGGTGACACTGTAAACACAGCCTCTAGGATGGAAAGT
CACGGGCTTCCCAGCAAAGTGCATCTGAGCCCCACAGCCCACAGAGCCCTGAAAAACAAAGGGT
TTGAAATTGTCAGGAGAGGCGAGATCGAAGTGAAGGGGAAAGGAAAGATGACCACATACTTTCT
GATCCAGAACCTGAATGCCACCGAGGATGAGATAATGGGGCGACCTTCAGCCCCCGCTGATGGG
AAGGAAGTATGTACTCCCGGAAACCAAGTCAGGAAGTCCCCTGCTGTCCCGAGGAACACAGACC
ATCAGCAACAAGTCTACAAAGGAGACCCAGCAGACGGAACATGAACGATAAAGTCGGTAACGGA
GCTGCACGATGCTGCGAGGTGTGCAGGAGACCATGAAGGACCTTCTTGTGCCCTAAGAATCCTT
GAGACAGTAACTGTCTCAGACAGGAGGGTATGGGCTGTCCTCTCTCAAGAGCTCTTGATTCCAG
TTTCGTCTGGTTCTGAAAAGAAAGGTTCTGTCTTGCCAGCAGGTTTTACAGCCTTGTCACCTCT
TTTTCTACAAGCTAATTAGTGTGGGAGACTTCTTGCTGCCTTGGGCCATATGCTGCTTCTATGG
CTGTTAATGTGGGACATAAACCCCACTCCCTACCTCACCTGTGTTTGAAAGTTGCATCTGTTGA
CTCGGTCTGATCTCTGCAGCCTAAAACCCTTCCTCTTTGATCTGATGCTGTGCTGATTTGTCTG
GCCATTACTCCTCTTTGCTGGTTGTGACTTTATTTTTCAGTCTTACTGAAAAGGAAATTAAAAA
GTTGTTTTAAAA

hide sequence

RefSeq Acc Id:

XM_039093002 ⟹ XP_038948930

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,589,501 - 36,656,021 (-)	NCBI

RefSeq Acc Id:

XM_039093003 ⟹ XP_038948931

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,628,103 - 36,656,021 (-)	NCBI

RefSeq Acc Id:

XR_005493692

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	36,624,913 - 36,656,019 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001257640	(Get FASTA)	NCBI Sequence Viewer
	NP_036902	(Get FASTA)	NCBI Sequence Viewer
	XP_008768963	(Get FASTA)	NCBI Sequence Viewer
	XP_038948930	(Get FASTA)	NCBI Sequence Viewer
	XP_038948931	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41207	(Get FASTA)	NCBI Sequence Viewer
	AAF86581	(Get FASTA)	NCBI Sequence Viewer
	BAB68564	(Get FASTA)	NCBI Sequence Viewer
	BAC76406	(Get FASTA)	NCBI Sequence Viewer
	BAC76407	(Get FASTA)	NCBI Sequence Viewer
	BAC76408	(Get FASTA)	NCBI Sequence Viewer
	BAC76409	(Get FASTA)	NCBI Sequence Viewer
	BAC79379	(Get FASTA)	NCBI Sequence Viewer
	BAC79380	(Get FASTA)	NCBI Sequence Viewer
	EDL85290	(Get FASTA)	NCBI Sequence Viewer
	EDL85291	(Get FASTA)	NCBI Sequence Viewer
	EDL85292	(Get FASTA)	NCBI Sequence Viewer
	EDL85293	(Get FASTA)	NCBI Sequence Viewer
	EDL85294	(Get FASTA)	NCBI Sequence Viewer
	EDL85295	(Get FASTA)	NCBI Sequence Viewer
	EDL85296	(Get FASTA)	NCBI Sequence Viewer
	P22717	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_036902 ⟸ NM_012770
- Peptide Label:	isoform 2
- UniProtKB:	P22717 (UniProtKB/Swiss-Prot), A0A0G2K4T2 (UniProtKB/TrEMBL), Q80WX7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTYTVYDDIITIKLIQEACKVLDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENL DALHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSI LDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIP VCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVN IQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRG QMIWMESLRCMIFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKK KEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAA CEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISA KEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAH RALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSP AVPRNTDHQQQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSPDETKTSVVASGPVLSAFC VVL hide sequence

RefSeq Acc Id:	NP_001257640 ⟸ NM_001270711
- Peptide Label:	isoform 1
- UniProtKB:	P22717 (UniProtKB/Swiss-Prot), A0A0G2QC51 (UniProtKB/TrEMBL), Q80WX7 (UniProtKB/TrEMBL), Q91XJ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYGFINTCLQSLVTEKFGEETWEKLKASAEVQDVFMTYTVYDDIITIKLIQEACKVLDVSMEAI LKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAM LLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQIR GAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQP VYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFN ISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPKLRSLQELEESK MHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEH VANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKV ETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVG DKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFL IQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADASNEVTLAGS PVAGRNSTDAVNNQPSPDETKTSVVASGPVLSAFCVVL hide sequence

RefSeq Acc Id:

XP_008768963 ⟸ XM_008770741

- Peptide Label:

isoform X2

- Sequence:

show sequence

MCLFTSLWNLYGFINTCLQSLVTEKFGEETWEKLKASAEVQDVFMTYTVYDDIITIKLIQEACK
VLDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFR
VEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLV
VQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGK
GPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFS
IIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPKLR
SLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTET
LLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRL
TSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHT
GPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKG
KGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADG
T

hide sequence

RefSeq Acc Id:

ENSRNOP00000073161 ⟸ ENSRNOT00000087678

RefSeq Acc Id:

ENSRNOP00000071659 ⟸ ENSRNOT00000081912

RefSeq Acc Id:

ENSRNOP00000012948 ⟸ ENSRNOT00000012948

RefSeq Acc Id:	XP_038948930 ⟸ XM_039093002
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038948931 ⟸ XM_039093003
- Peptide Label:	isoform X3

Protein Domains

Guanylate cyclase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P22717-F1-model_v2	AlphaFold	P22717	1-682	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2770	AgrOrtholog
BioCyc Gene	G2FUF-13462	BioCyc
Ensembl Genes	ENSRNOG00000009440	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012948	ENTREZGENE
	ENSRNOP00000012948.4	UniProtKB/TrEMBL
	ENSRNOP00000071659	ENTREZGENE
	ENSRNOP00000071659.1	UniProtKB/TrEMBL
	ENSRNOP00000073161.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012948	ENTREZGENE
	ENSRNOT00000012948.6	UniProtKB/TrEMBL
	ENSRNOT00000081912	ENTREZGENE
	ENSRNOT00000081912.2	UniProtKB/TrEMBL
	ENSRNOT00000087678.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.450.260	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.70.1230	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.1520.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.780	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	A/G_cyclase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	H-NOX_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Heme_NO-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOB_dom_associated	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOB_dom_associated_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NO_sig/Golgi_transp_ligand-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25206	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	25206	ENTREZGENE
PANTHER	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2	UniProtKB/Swiss-Prot
	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2	UniProtKB/Swiss-Prot
	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2	UniProtKB/TrEMBL
	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2	UniProtKB/TrEMBL
Pfam	Guanylate_cyc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gucy1b2	PhenoGen
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CYCc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF111126	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55073	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K4T2	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2QC51	ENTREZGENE, UniProtKB/TrEMBL
	GCYB2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q80WX7	ENTREZGENE, UniProtKB/TrEMBL
	Q91XJ7	ENTREZGENE, UniProtKB/TrEMBL
	Q920Q1_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-27	Gucy1b2	guanylate cyclase 1 soluble subunit beta 2	Gucy1b2	guanylate cyclase 1, soluble, beta 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Gucy1b2	guanylate cyclase 1, soluble, beta 2		guanylate cyclase, soluble, beta 2	Name updated	1299863	APPROVED
2003-04-09	Gucy1b2	guanylate cyclase, soluble, beta 2		guanylate cyclase 1, soluble, beta 2	Name updated	629478	APPROVED
2002-06-10	Gucy1b2	guanylate cyclase 1, soluble, beta 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation	61495
gene_expression	expressed at higher levels in kidney and liver than Gucy1b1	61495
gene_process	maybe involved in the regulation of blood pressure	61495
gene_process	may control salt-sensitive hypertension	61495

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)