Tle5 (TLE family member 5, transcriptional modulator) - Rat Genome Database

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Gene: Tle5 (TLE family member 5, transcriptional modulator) Rattus norvegicus
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Symbol: Tle5
Name: TLE family member 5, transcriptional modulator
RGD ID: 2731
Description: Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of anoikis; and response to interleukin-1. Predicted to act upstream of or within several processes, including DNA-templated transcription; regulation of DNA-templated transcription; and skeletal system development. Located in nucleus. Orthologous to human TLE5 (TLE family member 5, transcriptional modulator); INTERACTS WITH bisphenol A; ethanol; nefazodone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Aes; amino enhancer of split; amino-terminal enhancer of split; Grg; Grg-5; groucho-related protein 5; MGC124620; R-esp1; related to Drosophila groucho; related to Drosophila groucho gene; TLE family member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,143,357 - 8,150,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,029,652 - 11,036,443 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,905,315 - 12,912,106 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,772,459 - 10,779,245 (-)NCBIRnor_WKY
Rnor_6.0711,012,843 - 11,018,156 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,180,239 - 11,187,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,616,545 - 9,621,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,616,544 - 9,621,684 (-)NCBI
Celera76,334,418 - 6,339,570 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. Schmidt CJ and Sladek TE, J Biol Chem 1993 Dec 5;268(34):25681-6.
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10322635   PMID:10660609   PMID:11984876   PMID:12050133   PMID:12477932   PMID:15006356   PMID:15489227   PMID:16002402   PMID:19460168   PMID:19796622   PMID:22871113   PMID:22952044  
PMID:27107012  


Genomics

Comparative Map Data
Tle5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,143,357 - 8,150,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,029,652 - 11,036,443 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,905,315 - 12,912,106 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,772,459 - 10,779,245 (-)NCBIRnor_WKY
Rnor_6.0711,012,843 - 11,018,156 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,180,239 - 11,187,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,616,545 - 9,621,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,616,544 - 9,621,684 (-)NCBI
Celera76,334,418 - 6,339,570 (-)NCBICelera
Cytogenetic Map7q11NCBI
TLE5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,052,910 - 3,062,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,052,910 - 3,063,107 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,052,908 - 3,062,964 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,003,908 - 3,013,964 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,003,907 - 3,013,371NCBI
Celera192,987,104 - 2,997,160 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,819,951 - 2,846,898 (-)NCBIHuRef
CHM1_1193,053,022 - 3,063,007 (-)NCBICHM1_1
T2T-CHM13v2.0193,026,363 - 3,036,419 (-)NCBIT2T-CHM13v2.0
Tle5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,395,278 - 81,402,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,395,322 - 81,402,196 (+)EnsemblGRCm39 Ensembl
GRCm381081,559,444 - 81,566,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,559,488 - 81,566,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv371081,022,305 - 81,029,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,962,732 - 80,969,293 (+)NCBIMGSCv36mm8
Celera1082,582,741 - 82,589,545 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tle5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,327,595 - 5,336,715 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,328,299 - 5,336,195 (+)NCBIChiLan1.0ChiLan1.0
TLE5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,029,627 - 3,038,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,030,550 - 3,040,375 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,078,933 - 2,089,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TLE5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2055,914,532 - 55,922,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,849,569 - 56,857,811 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,803,938 - 56,857,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,904,684 - 55,912,933 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,388,895 - 56,397,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,587,646 - 56,595,884 (+)NCBIUU_Cfam_GSD_1.0
Tle5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,081,073 - 216,088,483 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,746,843 - 1,752,275 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365881,746,300 - 1,753,727 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,492,233 - 75,501,542 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,492,208 - 75,501,543 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TLE5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,822,814 - 2,832,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660815,749,591 - 5,759,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tle5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,113,044 - 6,121,720 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,113,037 - 6,121,951 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tle5
21 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH127590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,375 - 8,143,590 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,862 - 11,013,076NCBIRnor6.0
Rnor_5.0711,180,258 - 11,180,472UniSTSRnor5.0
RGSC_v3.479,616,564 - 9,616,778UniSTSRGSC3.4
Celera76,334,437 - 6,334,651UniSTS
Cytogenetic Map7q11UniSTS
RH135261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,145,954 - 8,146,136 (+)MAPPERmRatBN7.2
Rnor_6.0711,015,602 - 11,015,783NCBIRnor6.0
Rnor_5.0711,182,837 - 11,183,018UniSTSRnor5.0
RGSC_v3.479,619,143 - 9,619,324UniSTSRGSC3.4
Celera76,337,016 - 6,337,197UniSTS
RH 3.4 Map716.4UniSTS
Cytogenetic Map7q11UniSTS
RH125487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,376 - 8,143,592 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,863 - 11,013,078NCBIRnor6.0
Rnor_5.0711,180,259 - 11,180,474UniSTSRnor5.0
RGSC_v3.479,616,565 - 9,616,780UniSTSRGSC3.4
Celera76,334,438 - 6,334,653UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:532261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,385 - 8,143,805 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,872 - 11,013,291NCBIRnor6.0
Rnor_5.0711,180,268 - 11,180,687UniSTSRnor5.0
Celera76,334,447 - 6,334,866UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 1 2
Medium 3 41 57 41 19 41 8 10 72 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000092061   ⟹   ENSRNOP00000071178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,143,357 - 8,148,740 (-)Ensembl
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098364   ⟹   ENSRNOP00000079330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,143,357 - 8,149,184 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100632   ⟹   ENSRNOP00000097044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,143,357 - 8,149,231 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113477   ⟹   ENSRNOP00000092723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)Ensembl
RefSeq Acc Id: NM_019220   ⟹   NP_062093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,143,357 - 8,150,156 (-)NCBI
Rnor_6.0711,012,843 - 11,018,156 (-)NCBI
Rnor_5.0711,180,239 - 11,187,223 (-)NCBI
RGSC_v3.479,616,545 - 9,621,697 (-)RGD
Celera76,334,418 - 6,339,570 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078583   ⟹   XP_038934511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,143,357 - 8,150,273 (-)NCBI
RefSeq Acc Id: XM_039078584   ⟹   XP_038934512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,143,357 - 8,150,279 (-)NCBI
RefSeq Acc Id: XM_039078585   ⟹   XP_038934513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,143,357 - 8,150,273 (-)NCBI
RefSeq Acc Id: XM_039078586   ⟹   XP_038934514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,144,838 - 8,150,287 (-)NCBI
RefSeq Acc Id: XM_039078587   ⟹   XP_038934515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,145,766 - 8,150,295 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062093   ⟸   NM_019220
- UniProtKB: Q3MIF3 (UniProtKB/Swiss-Prot),   P63003 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071178   ⟸   ENSRNOT00000092061
RefSeq Acc Id: XP_038934512   ⟸   XM_039078584
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934513   ⟸   XM_039078585
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934511   ⟸   XM_039078583
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934514   ⟸   XM_039078586
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934515   ⟸   XM_039078587
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000097044   ⟸   ENSRNOT00000100632
RefSeq Acc Id: ENSRNOP00000079330   ⟸   ENSRNOT00000098364
RefSeq Acc Id: ENSRNOP00000092723   ⟸   ENSRNOT00000113477
Protein Domains
TLE_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63003-F1-model_v2 AlphaFold P63003 1-197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694967
Promoter ID:EPDNEW_R5492
Type:single initiation site
Name:Aes_1
Description:amino-terminal enhancer of split
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,018,137 - 11,018,197EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2731 AgrOrtholog
BioCyc Gene G2FUF-35040 BioCyc
Ensembl Genes ENSRNOG00000052025 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071178.2 UniProtKB/TrEMBL
  ENSRNOP00000079330.1 UniProtKB/TrEMBL
  ENSRNOP00000092723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000097044 ENTREZGENE
  ENSRNOP00000097044.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092061.2 UniProtKB/TrEMBL
  ENSRNOT00000098364.1 UniProtKB/TrEMBL
  ENSRNOT00000100632 ENTREZGENE
  ENSRNOT00000100632.1 UniProtKB/TrEMBL
  ENSRNOT00000113477 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933368 IMAGE-MGC_LOAD
InterPro Groucho/TLE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Groucho_enhance UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29466 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124620 IMAGE-MGC_LOAD
NCBI Gene 29466 ENTREZGENE
PANTHER PTHR10814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TLE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tle5 PhenoGen
TIGR TC216876
UniProt A0A0G2JZT6_RAT UniProtKB/TrEMBL
  A0A8I6ARX3_RAT UniProtKB/TrEMBL
  A0A8I6G347_RAT UniProtKB/TrEMBL
  P63003 ENTREZGENE
  Q3MIF3 ENTREZGENE
  TLE5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q06195 UniProtKB/Swiss-Prot
  Q3MIF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Tle5  TLE family member 5, transcriptional modulator  Aes  amino-terminal enhancer of split  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aes  amino-terminal enhancer of split       Name updated 70584 APPROVED
2001-10-24 Aes  amino-terminal enhancer of split      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state 724707