Emd (emerin) - Rat Genome Database

Name: Emd
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Emd (emerin) Rattus norvegicus

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Symbol:

Emd

Name:

emerin

RGD ID:

2551

Description:

Predicted to enable actin binding activity and beta-tubulin binding activity. Involved in nuclear membrane reassembly. Located in nuclear envelope. Human ortholog(s) of this gene implicated in Emery-Dreifuss muscular dystrophy; X-linked Emery-Dreifuss muscular dystrophy 1; and dilated cardiomyopathy. Orthologous to human EMD (emerin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EMD (emerin)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Emd (emerin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EMD (emerin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-150o23.2	Alliance	DIOPT (InParanoid\|OrthoFinder\|SonicParanoid)
Danio rerio (zebrafish):	emd (emerin (Emery-Dreifuss muscular dystrophy))	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,190,438 - 157,193,479 (+)	NCBI		GRCr8
mRatBN7.2	X	152,038,990 - 152,042,190 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,038,998 - 152,045,807 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,180,279 - 154,183,290 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,743,512 - 157,746,523 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,415,308 - 155,418,319 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,452,847 - 156,455,858 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,452,818 - 156,456,035 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,192,993 - 152,196,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,351,228 - 160,354,239 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,427,431 - 160,430,442 (-)	NCBI
Celera	1	135,854,577 - 135,857,588 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cardiomyopathy (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1A (ISO)

dilated cardiomyopathy 1B (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

familial hypertrophic cardiomyopathy (ISO)

favism (ISO)

hypertrophic cardiomyopathy (ISO)

immunodeficiency 33 (ISO)

myopathy (ISO)

neuromuscular disease (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked Emery-Dreifuss muscular dystrophy 1 (ISO)

X-linked Emery-Dreifuss muscular dystrophy 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-diaminodiphenylmethane (ISO)

acrolein (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

Brodifacoum (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP)

chromium(6+) (ISO)

clofibrate (ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (EXP)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

inulin (ISO)

ivermectin (ISO)

methyl salicylate (ISO)

ozone (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

temozolomide (ISO)

testosterone enanthate (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid fibril formation (ISO)

cellular response to growth factor stimulus (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IBA,IEA,ISO)

negative regulation of fibroblast proliferation (IEA,ISO)

nuclear membrane organization (IEA,ISO)

nuclear membrane reassembly (IEP)

positive regulation of protein export from nucleus (IEA,ISO)

regulation of canonical Wnt signaling pathway (ISO)

skeletal muscle cell differentiation (IEA,ISO)

Cellular Component

cortical endoplasmic reticulum (IEA,ISO)

cytoplasm (ISO)

endoplasmic reticulum (ISO)

membrane (IEA)

microtubule (IEA)

nuclear envelope (IDA,IEA,ISO)

nuclear inner membrane (IBA,IEA,ISO)

nuclear membrane (ISO)

nuclear outer membrane (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

spindle (IBA)

spindle pole centrosome (IEA,ISO)

TMEM240-body (IEA,ISO)

Molecular Function

actin binding (IBA,IEA,ISO)

beta-tubulin binding (IBA,IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy pathway (IEA)

dilated cardiomyopathy pathway (IEA)

hypertrophic cardiomyopathy pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy.	Bione S, etal., Nat Genet. 1994 Dec;8(4):323-7.
2.	Distribution of emerin during the cell cycle.	Dabauvalle MC, etal., Eur J Cell Biol 1999 Oct;78(10):749-56.
3.	Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype.	Ellis JA, etal., J Cell Sci 1998 Mar;111 ( Pt 6):781-92.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Whole exome sequencing identifies a novel EMD mutation in a Chinese family with dilated cardiomyopathy.	Zhang M, etal., BMC Med Genet. 2014 Jul 5;15:77. doi: 10.1186/1471-2350-15-77.

Additional References at PubMed

PMID:15328537	PMID:16283426	PMID:16858403	PMID:17164264	PMID:17785515	PMID:19167377	PMID:19494128	PMID:19720741	PMID:19933576	PMID:19946888	PMID:21610090	PMID:22349700
PMID:25468996	PMID:27114541	PMID:27534416	PMID:28290476	PMID:32926941

Genomics

Comparative Map Data

Emd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,190,438 - 157,193,479 (+)	NCBI		GRCr8
mRatBN7.2	X	152,038,990 - 152,042,190 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,038,998 - 152,045,807 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,180,279 - 154,183,290 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,743,512 - 157,746,523 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,415,308 - 155,418,319 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,452,847 - 156,455,858 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,452,818 - 156,456,035 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,192,993 - 152,196,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,351,228 - 160,354,239 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,427,431 - 160,430,442 (-)	NCBI
Celera	1	135,854,577 - 135,857,588 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

EMD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,379,295 - 154,381,523 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,379,273 - 154,381,574 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,607,655 - 153,609,883 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,260,981 - 153,263,075 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,128,633 - 153,130,728	NCBI
Celera	X	153,768,677 - 153,770,963 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,185,074 - 142,187,360 (+)	NCBI		HuRef
CHM1_1	X	153,519,221 - 153,521,507 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,610,118 - 152,618,066 (+)	NCBI		T2T-CHM13v2.0

Emd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,298,297 - 73,305,188 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,298,293 - 73,305,154 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,254,674 - 74,261,563 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,254,687 - 74,261,548 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	X	74,261,032 - 74,261,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,500,178 - 71,503,086 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,507,559 - 70,510,467 (+)	NCBI		MGSCv36	mm8
Celera	X	65,508,981 - 65,511,889 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.92	NCBI

Emd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	864,532 - 866,904 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	864,532 - 866,904 (-)	NCBI	ChiLan1.0	ChiLan1.0

EMD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,324,795 - 154,332,696 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,328,400 - 154,330,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,792,178 - 143,794,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

EMD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,050,309 - 122,052,629 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,050,455 - 122,052,524 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	107,379,062 - 107,381,339 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	125,192,020 - 125,194,303 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,192,024 - 125,204,015 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,961,089 - 120,963,363 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,475,997 - 123,478,261 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,237,823 - 123,240,104 (-)	NCBI		UU_Cfam_GSD_1.0

Emd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,389,931 - 119,392,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,127,710 - 1,130,195 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,127,701 - 1,130,195 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,883,049 - 124,885,432 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,883,047 - 124,885,429 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EMD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,689,588 - 128,692,105 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,689,588 - 128,692,625 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	66,578,574 - 66,581,198 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	801,639 - 808,162 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	805,573 - 808,001 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Emd
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	67
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000056282
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

AI176340

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	152,041,906 - 152,042,150 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	156,452,857 - 156,453,100	NCBI	Rnor6.0
Rnor_5.0	1	152,193,003 - 152,193,246	UniSTS	Rnor5.0
RGSC_v3.4	X	160,351,238 - 160,351,481	UniSTS	RGSC3.4
Celera	1	135,854,587 - 135,854,830	UniSTS
Cytogenetic Map	X	q37	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC059151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X98377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080990 ⟹ ENSRNOP00000075584

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,038,998 - 152,042,184 (+)	Ensembl
Rnor_6.0 Ensembl	X	156,452,818 - 156,456,035 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101200 ⟹ ENSRNOP00000083369

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,039,256 - 152,042,188 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103763 ⟹ ENSRNOP00000090616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,038,998 - 152,045,807 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108345 ⟹ ENSRNOP00000096388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,039,149 - 152,042,188 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114008 ⟹ ENSRNOP00000087293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,038,998 - 152,045,736 (+)	Ensembl

RefSeq Acc Id:

NM_012948 ⟹ NP_037080

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,190,438 - 157,193,449 (+)	NCBI
mRatBN7.2	X	152,039,149 - 152,042,160 (+)	NCBI
Rnor_6.0	X	156,452,847 - 156,455,858 (-)	NCBI
Rnor_5.0	1	152,192,993 - 152,196,004 (-)	NCBI
RGSC_v3.4	X	160,351,228 - 160,354,239 (-)	RGD
Celera	1	135,854,577 - 135,857,588 (-)	NCBI

Sequence:

show sequence

AGAGCGGCGCTTCCTCTGCTAGGCTGCGAGCTGTCTGTTTCTTGGGCCCTGTGTATAGGTGCCG
GCCGCCCCTGGCGTTCAACACCGCTTCCAGGTGCCGGCCGTGTCTGCCATGGACGACTATGCGG
TTTTGTCCGATACTGAGCTGGCCGCAGTGCTACGCCAGTACAACATCCCGCATGGGCCTATTCT
GGGCTCCACTCGCAAGCTCTACGAAAAGAAAATCTTCGAGTACGAGACCCAGAGAAGGAGGCTT
TCGCCCCCCAGCTCGTCATCGTCTTCATTCTCCTATCGGTTCTCAGACTTGGATTCAGCCTCCG
TGGACTCAGACATGTATGATCTGCCCAAAAAGGAGGACGCCTTACTTTACCAGAGCAAGGACTA
TAATGATGACTACTATGAGGAGAGCTATTTGACTACCAGGACATACGGGGAGCCCGAGTCTGTG
GGCATGTCCAAGAGCTTCCGCCGGCCAGGGACCTCACTTGTAGATGCTGATGATACCTTCCATC
ACCAGGTGCGTGATGACATTTTCTCTTCTTCAGAAGAGGAAGGCAAGGATAGGGAACGCCCCAT
CTATGGCCGAGACAGTGCCTACCAGAGCATCGCAGAGTACCGCCCCATTTCCAATGTCTCCAGG
AGCTCCCTGGGCTTATCATATTATCCTAGATCCTCCACCTCTTCTGTGTCCTCCTCTTCATCTT
CTCCCTCTTCATGGCTTACCCGACGTGCCATTCGACCAGAAAAGCAGGCCCCTACTGCTGCTCT
GGGCCAGGATCGACAGGTCCCACTCTGGGGCCAGCTGTTACTCTTCCTGGCCTTTGCTACCTTT
CTGCTCTTTGTTTACTATTCCATACAAGCTCAAGAAGGCAACCCCTTCTGGATGGATCCCTAAG
GGTATTGGTTTCAGAGCAGCTCTTAACAGGAGTTTTGGCTGACTGCCTTAGCAGTGTTTGCTGG
GGGTGGGGGGTAGGGGCTTTTTTGTGTATTCTAGTTAGAGGGTACAGGGCCCTTACTACGGCAG
TGCTTGTCTCCACCTCATCTTGCCAAGGAAGCAGCAAATGCTGGCTTTCCACAGCCCAGTAGGC
CCTATGTACCTTCCTCTGGAGCCTCCTAGCCTTATTGCCTCTGACTCTTAGGGTATGGGGATCT
GGTGGGGAGGACCTCACTTCATTAGAGGAAAACTTGGTGGTGGCAGTGGTAGTTGTCATGCATG
CCTGTTTGTTGTCACCTTTTCAGGGGGTATTAACAAGGCCATCCTGGCTTTGCTTTCG

hide sequence

RefSeq Acc Id:

XM_039099500 ⟹ XP_038955428

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,190,488 - 157,193,479 (+)	NCBI
mRatBN7.2	X	152,038,992 - 152,042,190 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037080	(Get FASTA)	NCBI Sequence Viewer
	XP_038955428	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH59151	(Get FASTA)	NCBI Sequence Viewer
	CAA67023	(Get FASTA)	NCBI Sequence Viewer
	EDL84988	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075584.1
	ENSRNOP00000083369.1
	ENSRNOP00000087293.1
	ENSRNOP00000090616.1
	ENSRNOP00000096388.1
GenBank Protein	Q63190	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037080 ⟸ NM_012948

- UniProtKB:

Q63190 (UniProtKB/Swiss-Prot), Q6PCU4 (UniProtKB/TrEMBL), A0A0G2KAZ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDYAVLSDTELAAVLRQYNIPHGPILGSTRKLYEKKIFEYETQRRRLSPPSSSSSSFSYRFSD
LDSASVDSDMYDLPKKEDALLYQSKDYNDDYYEESYLTTRTYGEPESVGMSKSFRRPGTSLVDA
DDTFHHQVRDDIFSSSEEEGKDRERPIYGRDSAYQSIAEYRPISNVSRSSLGLSYYPRSSTSSV
SSSSSSPSSWLTRRAIRPEKQAPTAALGQDRQVPLWGQLLLFLAFATFLLFVYYSIQAQEGNPF
WMDP

hide sequence

Ensembl Acc Id:

ENSRNOP00000075584 ⟸ ENSRNOT00000080990

RefSeq Acc Id:	XP_038955428 ⟸ XM_039099500
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G8X3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000096388 ⟸ ENSRNOT00000108345

Ensembl Acc Id:

ENSRNOP00000090616 ⟸ ENSRNOT00000103763

Ensembl Acc Id:

ENSRNOP00000087293 ⟸ ENSRNOT00000114008

Ensembl Acc Id:

ENSRNOP00000083369 ⟸ ENSRNOT00000101200

Protein Domains

LEM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63190-F1-model_v2	AlphaFold	Q63190	1-260	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2551	AgrOrtholog
BioCyc Gene	G2FUF-637	BioCyc
Ensembl Genes	ENSRNOG00000058882	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000080990.2	UniProtKB/TrEMBL
	ENSRNOT00000101200.1	UniProtKB/TrEMBL
	ENSRNOT00000103763.1	UniProtKB/TrEMBL
	ENSRNOT00000108345.1	UniProtKB/TrEMBL
	ENSRNOT00000114008.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.720.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6919042	IMAGE-MGC_LOAD
InterPro	Emerin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LEM/LEM-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LEM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LEM_emerin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25437	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72923	IMAGE-MGC_LOAD
NCBI Gene	25437	ENTREZGENE
PANTHER	EMERIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15171	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LEM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Emd	PhenoGen
PROSITE	LEM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058882	RatGTEx
SMART	LEM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF63451	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC206342
UniProt	A0A0G2KAZ3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A5J4_RAT	UniProtKB/TrEMBL
	A0A8I6ADW3_RAT	UniProtKB/TrEMBL
	A0A8I6AV07_RAT	UniProtKB/TrEMBL
	A0A8I6G8X3	ENTREZGENE, UniProtKB/TrEMBL
	EMD_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6PCU4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Emd	Emerin			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)