Mir450a1 (microRNA 450a-1) - Rat Genome Database

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Gene: Mir450a1 (microRNA 450a-1) Rattus norvegicus
Analyze
Symbol: Mir450a1
Name: microRNA 450a-1
RGD ID: 2325535
Description: Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Orthologous to human MIR450A1 (microRNA 450a-1); INTERACTS WITH 2,5-hexanedione; atrazine; bleomycin A2.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: ENSRNOG00000069292; microRNA 450a; microRNA mir-450a; Mir450a; rno-mir-450a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,720,933 - 137,721,023 (-)NCBIGRCr8
mRatBN7.2X132,801,380 - 132,801,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,801,380 - 132,801,470 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,961,429 - 134,961,519 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,544,277 - 138,544,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X136,109,989 - 136,110,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,153,377 - 158,153,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,153,377 - 158,153,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,778,684 - 152,778,774 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15735639   PMID:16381832   PMID:20403161   PMID:20439489   PMID:28167681  


Genomics

Comparative Map Data
Mir450a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,720,933 - 137,721,023 (-)NCBIGRCr8
mRatBN7.2X132,801,380 - 132,801,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,801,380 - 132,801,470 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,961,429 - 134,961,519 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,544,277 - 138,544,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X136,109,989 - 136,110,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,153,377 - 158,153,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,153,377 - 158,153,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,778,684 - 152,778,774 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic MapXq36NCBI
MIR450A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,540,341 - 134,540,431 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,540,341 - 134,540,431 (-)EnsemblGRCh38hg38GRCh38
GRCh37X133,674,371 - 133,674,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,502,036 - 133,502,126 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX134,061,199 - 134,061,289 (-)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX123,073,367 - 123,073,457 (-)NCBIHuRef
CHM1_1X133,586,121 - 133,586,211 (-)NCBICHM1_1
T2T-CHM13v2.0X132,865,540 - 132,865,630 (-)NCBIT2T-CHM13v2.0
Mir450-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X52,137,031 - 52,137,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX52,137,031 - 52,137,121 (-)EnsemblGRCm39 Ensembl
GRCm38X53,048,154 - 53,048,244 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX53,048,154 - 53,048,244 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X50,401,331 - 50,401,421 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX40,474,149 - 40,474,239 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.31NCBI
MIR450A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X105,177,439 - 105,177,529 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX105,177,439 - 105,177,529 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,288,110 - 91,288,200 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X107,037,191 - 107,037,281 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX107,037,191 - 107,037,281 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,450,644 - 104,450,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,316,621 - 106,316,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X106,108,087 - 106,108,177 (-)NCBIUU_Cfam_GSD_1.0
MIR450A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,381,746 - 110,381,851 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,381,746 - 110,381,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Hnrnpkrno-miR-450a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18230805

Predicted Targets
Summary Value
Count of predictions:9664
Count of gene targets:6017
Count of transcripts:6422
Interacting mature miRNAs:rno-miR-450a-3p, rno-miR-450a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 20 6 4 4 10 12 27 1
Below cutoff 4 3 2 2 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000072575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX158,153,377 - 158,153,467 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,801,380 - 132,801,470 (-)Ensembl
RefSeq Acc Id: NR_031951
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,720,933 - 137,721,023 (-)NCBI
mRatBN7.2X132,801,380 - 132,801,470 (-)NCBI
Rnor_6.0X158,153,377 - 158,153,467 (+)NCBI
Rnor_5.0X152,778,684 - 152,778,774 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325535 AgrOrtholog
BioCyc Gene G2FUF-1001 BioCyc
Ensembl Genes ENSRNOG00000047823 Ensembl
  ENSRNOG00000069292 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000113417 ENTREZGENE
miRBase MI0001654 ENTREZGENE
NCBI Gene 100314069 ENTREZGENE
PhenoGen Mir450a1 PhenoGen
RatGTEx ENSRNOG00000047823 RatGTEx
  ENSRNOG00000069292 RatGTEx
RNAcentral URS00006D76DD RNACentral
  URS000075994E RNACentral
  URS000075DC83 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mir450a1  microRNA 450a-1  ENSRNOG00000069292    Data merged from RGD:150343115 737654 PROVISIONAL
2021-08-31 ENSRNOG00000069292        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-10-15 Mir450a1  microRNA 450a-1  Mir450a  microRNA 450a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-15 Mir450a  microRNA 450a  Mir450a  microRNA mir-450a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir450a  microRNA mir-450a      Symbol and Name status set to provisional 70820 PROVISIONAL