Mir448 (microRNA 448) - Rat Genome Database

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Gene: Mir448 (microRNA 448) Rattus norvegicus
Analyze
Symbol: Mir448
Name: microRNA 448
RGD ID: 2325372
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of sodium ion import across plasma membrane; positive regulation of vascular associated smooth muscle cell migration; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within negative regulation of fat cell differentiation and negative regulation of translation. Orthologous to human MIR448 (microRNA 448); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH atrazine; bisphenol A; furan.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-448
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,641,955 - 115,642,066 (+)NCBIGRCr8
mRatBN7.2X110,829,918 - 110,830,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX110,829,918 - 110,830,029 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX112,915,695 - 112,915,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,414,554 - 116,414,665 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X113,973,880 - 113,973,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,277,684 - 118,277,795 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,277,684 - 118,277,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X118,420,170 - 118,420,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX110,139,473 - 110,139,584 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15735639   PMID:16381832   PMID:20403161   PMID:20719859   PMID:29067448   PMID:29561961   PMID:30322616   PMID:32012267   PMID:32542696   PMID:33994507  


Genomics

Comparative Map Data
Mir448
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,641,955 - 115,642,066 (+)NCBIGRCr8
mRatBN7.2X110,829,918 - 110,830,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX110,829,918 - 110,830,029 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX112,915,695 - 112,915,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,414,554 - 116,414,665 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X113,973,880 - 113,973,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,277,684 - 118,277,795 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,277,684 - 118,277,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X118,420,170 - 118,420,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX110,139,473 - 110,139,584 (+)NCBICelera
Cytogenetic MapXq34NCBI
MIR448
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X114,823,454 - 114,823,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX114,823,454 - 114,823,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37X114,058,017 - 114,058,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,964,272 - 113,964,382 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX114,493,182 - 114,493,292 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX103,645,551 - 103,645,661 (+)NCBIHuRef
CHM1_1X113,968,888 - 113,968,998 (+)NCBICHM1_1
T2T-CHM13v2.0X113,232,146 - 113,232,256 (+)NCBIT2T-CHM13v2.0
Mir448
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,941,206 - 145,941,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX145,941,206 - 145,941,317 (+)EnsemblGRCm39 Ensembl
GRCm38X147,158,210 - 147,158,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX147,158,210 - 147,158,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X143,592,753 - 143,592,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX131,097,223 - 131,097,272 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
MIR448
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X87,558,063 - 87,558,172 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX87,558,063 - 87,558,172 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX73,676,255 - 73,676,364 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X89,270,890 - 89,270,999 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX89,270,890 - 89,270,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X86,714,503 - 86,714,612 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X88,388,781 - 88,388,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,221,445 - 88,221,554 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:7343
Count of gene targets:4691
Count of transcripts:5044
Interacting mature miRNAs:rno-miR-448-3p, rno-miR-448-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system respiratory system
High
Medium
Low 3 1
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX110,829,918 - 110,830,029 (+)Ensembl
Rnor_6.0 EnsemblX118,277,684 - 118,277,795 (+)Ensembl
RefSeq Acc Id: NR_031948
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,641,955 - 115,642,066 (+)NCBI
mRatBN7.2X110,829,918 - 110,830,029 (+)NCBI
Rnor_6.0X118,277,684 - 118,277,795 (+)NCBI
Rnor_5.0X118,420,170 - 118,420,281 (+)NCBI
CeleraX110,139,473 - 110,139,584 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325372 AgrOrtholog
BioCyc Gene G2FUF-1444 BioCyc
Ensembl Genes ENSRNOG00000035635 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053758 ENTREZGENE
miRBase MI0001639 ENTREZGENE
NCBI Gene 100314251 ENTREZGENE
PhenoGen Mir448 PhenoGen
RatGTEx ENSRNOG00000035635 RatGTEx
RNAcentral URS00006670FC RNACentral
  URS000075A1C9 RNACentral
  URS000075A855 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir448  microRNA 448  Mir448  microRNA mir-448  Name updated 61478 APPROVED
2010-06-02 Mir448  microRNA mir-448      Symbol and Name status set to provisional 70820 PROVISIONAL