Mir873 (microRNA 873) - Rat Genome Database

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Gene: Mir873 (microRNA 873) Rattus norvegicus
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Symbol: Mir873
Name: microRNA 873
RGD ID: 2325356
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of cardiac muscle cell proliferation and negative regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within with a positive effect on gene expression. Predicted to act upstream of or within miRNA-mediated gene silencing. Orthologous to human MIR873 (microRNA 873); INTERACTS WITH 2,5-hexanedione; cadmium dichloride; zinc atom.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-873; rno-mir-873
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2551,356,919 - 51,356,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl551,356,919 - 51,356,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx553,320,198 - 53,320,274 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0555,139,368 - 55,139,444 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0555,041,296 - 55,041,372 (-)NCBIRnor_WKY
Rnor_6.0552,481,076 - 52,481,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl552,481,076 - 52,481,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0557,038,981 - 57,039,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera550,059,432 - 50,059,508 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:28583401   PMID:28837808   PMID:31910027   PMID:31960421   PMID:33378038   PMID:34844996  


Genomics

Comparative Map Data
Mir873
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2551,356,919 - 51,356,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl551,356,919 - 51,356,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx553,320,198 - 53,320,274 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0555,139,368 - 55,139,444 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0555,041,296 - 55,041,372 (-)NCBIRnor_WKY
Rnor_6.0552,481,076 - 52,481,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl552,481,076 - 52,481,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0557,038,981 - 57,039,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera550,059,432 - 50,059,508 (-)NCBICelera
Cytogenetic Map5q22NCBI
MIR873
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38928,888,879 - 28,888,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl928,888,879 - 28,888,955 (-)EnsemblGRCh38hg38GRCh38
GRCh37928,888,877 - 28,888,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36928,878,876 - 28,878,952 (-)NCBINCBI36Build 36hg18NCBI36
Celera928,817,754 - 28,817,830 (-)NCBICelera
Cytogenetic Map9p21.1NCBI
HuRef928,841,476 - 28,841,552 (-)NCBIHuRef
CHM1_1928,888,674 - 28,888,750 (-)NCBICHM1_1
T2T-CHM13v2.0928,902,129 - 28,902,205 (-)NCBIT2T-CHM13v2.0
Mir873a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39436,668,510 - 36,668,586 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl436,668,510 - 36,668,586 (-)EnsemblGRCm39 Ensembl
GRCm38436,668,510 - 36,668,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl436,668,510 - 36,668,586 (-)EnsemblGRCm38mm10GRCm38
MGSCv37436,615,543 - 36,615,619 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera436,365,478 - 36,365,554 (-)NCBICelera
Cytogenetic Map4A5NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:9474
Count of gene targets:5587
Count of transcripts:5978
Interacting mature miRNAs:rno-miR-873-3p, rno-miR-873-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium 3
Low 4 4 26 3 4
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000063058
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl551,356,919 - 51,356,995 (-)Ensembl
Rnor_6.0 Ensembl552,481,076 - 52,481,152 (-)Ensembl
RefSeq Acc Id: NR_032297
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2551,356,919 - 51,356,995 (-)NCBI
Rnor_6.0552,481,076 - 52,481,152 (-)NCBI
Rnor_5.0557,038,981 - 57,039,057 (-)NCBI
Celera550,059,432 - 50,059,508 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325356 AgrOrtholog
BioCyc Gene G2FUF-41622 BioCyc
Ensembl Genes ENSRNOG00000041305 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000063058 ENTREZGENE
miRBase MI0006166 ENTREZGENE
NCBI Gene 100314267 ENTREZGENE
PhenoGen Mir873 PhenoGen
RNAcentral URS0000159275 RNACentral
  URS00004996E9 RNACentral
  URS0000664023 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir873  microRNA 873  Mir873  microRNA mir-873  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir873  microRNA mir-873      Symbol and Name status set to provisional 70820 PROVISIONAL