Lrriq4 (leucine-rich repeats and IQ motif containing 4) - Rat Genome Database

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Gene: Lrriq4 (leucine-rich repeats and IQ motif containing 4) Rattus norvegicus
Analyze
Symbol: Lrriq4
Name: leucine-rich repeats and IQ motif containing 4
RGD ID: 2323202
Description: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Orthologous to human LRRIQ4 (leucine rich repeats and IQ motif containing 4); INTERACTS WITH arsane (ortholog); arsenic atom (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Lap1-like; leucine-rich repeat and IQ domain-containing protein 4; LOC100363341
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,657,816 - 114,685,245 (-)NCBIGRCr8
mRatBN7.22112,729,298 - 112,756,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,729,417 - 112,753,234 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02116,347,125 - 116,372,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,347,336 - 116,374,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02136,040,977 - 136,066,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42117,147,469 - 117,174,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2107,908,333 - 107,933,912 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Lrriq4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,657,816 - 114,685,245 (-)NCBIGRCr8
mRatBN7.22112,729,298 - 112,756,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,729,417 - 112,753,234 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02116,347,125 - 116,372,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,347,336 - 116,374,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02136,040,977 - 136,066,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42117,147,469 - 117,174,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2107,908,333 - 107,933,912 (-)NCBICelera
Cytogenetic Map2q24NCBI
LRRIQ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383169,812,870 - 169,837,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3169,812,870 - 169,837,773 (+)EnsemblGRCh38hg38GRCh38
GRCh373169,530,658 - 169,555,561 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,022,404 - 171,038,255 (+)NCBINCBI36Build 36hg18NCBI36
Celera3167,938,185 - 167,954,845 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3166,909,642 - 166,925,430 (+)NCBIHuRef
CHM1_13169,502,722 - 169,518,551 (+)NCBICHM1_1
T2T-CHM13v2.03172,597,096 - 172,621,997 (+)NCBIT2T-CHM13v2.0
Lrriq4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39330,698,636 - 30,726,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl330,698,656 - 30,726,580 (+)EnsemblGRCm39 Ensembl
GRCm38330,644,487 - 30,672,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl330,644,507 - 30,672,431 (+)EnsemblGRCm38mm10GRCm38
MGSCv37330,543,429 - 30,571,353 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36330,835,345 - 30,863,204 (+)NCBIMGSCv36mm8
Celera330,557,284 - 30,585,561 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map314.27NCBI
Lrriq4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542071,451 - 102,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542066,770 - 100,154 (+)NCBIChiLan1.0ChiLan1.0
LRRIQ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22167,706,296 - 167,732,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13167,711,019 - 167,736,944 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03166,826,765 - 166,851,766 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13174,880,261 - 174,905,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3174,880,261 - 174,905,120 (+)Ensemblpanpan1.1panPan2
LRRIQ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,422,443 - 34,442,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,428,699 - 34,442,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03434,501,030 - 34,521,195 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,505,958 - 34,521,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,447,437 - 34,467,541 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,414,523 - 34,434,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03434,679,224 - 34,699,532 (+)NCBIUU_Cfam_GSD_1.0
Lrriq4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,021,923 - 101,038,666 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,583,296 - 2,602,648 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365932,583,280 - 2,600,043 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRIQ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13108,487,546 - 108,519,806 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113108,500,055 - 108,520,792 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,222,727 - 117,257,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRIQ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,561,764 - 19,586,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1519,561,865 - 19,577,286 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606328,367,772 - 28,383,892 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrriq4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473047,863,874 - 47,892,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrriq4
184 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:30
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000011932, ENSRNOT00000058919
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 8 19 2 1 8 11
Below cutoff 2 13 14 6 6 5 6 34 34 11 5

Sequence


RefSeq Acc Id: ENSRNOT00000011932   ⟹   ENSRNOP00000011932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,729,417 - 112,753,234 (-)Ensembl
Rnor_6.0 Ensembl2116,347,336 - 116,372,226 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000058919   ⟹   ENSRNOP00000055703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2116,347,336 - 116,374,584 (-)Ensembl
RefSeq Acc Id: XM_039103607   ⟹   XP_038959535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,657,816 - 114,685,245 (-)NCBI
mRatBN7.22112,729,298 - 112,756,338 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038959535 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011932
  ENSRNOP00000011932.7
RefSeq Acc Id: ENSRNOP00000011932   ⟸   ENSRNOT00000011932
RefSeq Acc Id: ENSRNOP00000055703   ⟸   ENSRNOT00000058919
RefSeq Acc Id: XP_038959535   ⟸   XM_039103607
- UniProtKB: F1M0Y2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVF0-F1-model_v2 AlphaFold F1LVF0 1-594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323202 AgrOrtholog
BioCyc Gene G2FUF-53454 BioCyc
Ensembl Genes ENSRNOG00000009004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011932.8 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
NCBI Gene 100363341 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT CONTAINING PROTEIN UniProtKB/TrEMBL
  LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
PhenoGen Lrriq4 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009004 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt F1M0Y2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-11 Lrriq4  leucine-rich repeats and IQ motif containing 4  LOC100363341  Lap1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363341  Lap1-like      Symbol and Name status set to provisional 70820 PROVISIONAL