Pigy (phosphatidylinositol glycan anchor biosynthesis, class Y) - Rat Genome Database

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Gene: Pigy (phosphatidylinositol glycan anchor biosynthesis, class Y) Rattus norvegicus
Analyze
Symbol: Pigy
Name: phosphatidylinositol glycan anchor biosynthesis, class Y
RGD ID: 2318067
Description: Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 6. Orthologous to human PIGY (phosphatidylinositol glycan anchor biosynthesis class Y); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100365921; phosphatidylinositol glycan anchor biosynthesis, class Y-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; Pigyl; rCG31672-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,965,634 - 28,967,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,965,617 - 28,968,508 (+)EnsemblGRCr8
mRatBN7.2820,689,621 - 20,691,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,689,502 - 20,692,585 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,718,077 - 24,720,311 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0823,015,228 - 23,017,462 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,919,167 - 20,921,408 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,167,974 - 23,170,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,167,974 - 23,170,209 (+)Ensemblrn6Rnor6.0
Rnor_5.0823,221,295 - 23,223,536 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera822,078,318 - 22,080,559 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:16162815  


Genomics

Comparative Map Data
Pigy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,965,634 - 28,967,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,965,617 - 28,968,508 (+)EnsemblGRCr8
mRatBN7.2820,689,621 - 20,691,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,689,502 - 20,692,585 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,718,077 - 24,720,311 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0823,015,228 - 23,017,462 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,919,167 - 20,921,408 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,167,974 - 23,170,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,167,974 - 23,170,209 (+)Ensemblrn6Rnor6.0
Rnor_5.0823,221,295 - 23,223,536 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera822,078,318 - 22,080,559 (+)NCBICelera
Cytogenetic Map8q13NCBI
PIGY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,520,998 - 88,523,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl488,520,998 - 88,523,776 (-)Ensemblhg38GRCh38
GRCh37489,442,149 - 89,444,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,661,158 - 89,663,978 (-)NCBIBuild 36Build 36hg18NCBI36
Celera486,738,822 - 86,741,642 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef485,194,129 - 85,196,952 (-)NCBIHuRef
CHM1_1489,418,607 - 89,421,430 (-)NCBICHM1_1
T2T-CHM13v2.0491,852,644 - 91,855,421 (-)NCBIT2T-CHM13v2.0
Pigyl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39922,068,142 - 22,069,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl922,068,142 - 22,069,654 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38922,156,846 - 22,158,355 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl922,156,846 - 22,158,358 (+)Ensemblmm10GRCm38
MGSCv37921,961,290 - 21,962,799 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,907,268 - 21,908,750 (+)NCBIMGSCv36mm8
Celera919,425,815 - 19,427,324 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.46NCBI
Pigy
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547411,944,302 - 11,947,092 (+)Ensembl
ChiLan1.0NW_00495547411,945,871 - 11,946,419 (+)NCBIChiLan1.0ChiLan1.0
LOC103784916
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2386,524,595 - 86,527,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,787,084 - 86,790,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,810,555 - 80,813,329 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1491,533,268 - 91,536,090 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,533,268 - 91,536,850 (-)EnsemblpanPan2panpan1.1
PIGY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,808,967 - 11,812,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,142,083 - 30,145,550 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03211,862,485 - 11,865,733 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13211,945,115 - 11,953,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,770,336 - 11,773,803 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,143,350 - 28,146,819 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pigy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530129,570,615 - 29,571,337 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936685984,606 - 985,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110256448
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113162,392,377 - 162,394,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pigy
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475716,159,263 - 16,159,777 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pigy
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1818,406,721 - 18,408,988 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pigy
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:108
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000008973
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH127336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,691,598 - 20,691,798 (+)MAPPERmRatBN7.2
Rnor_6.0823,169,952 - 23,170,151NCBIRnor6.0
Rnor_5.0823,223,273 - 23,223,472UniSTSRnor5.0
Celera822,080,296 - 22,080,495UniSTS
RH128875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,690,796 - 20,690,984 (+)MAPPERmRatBN7.2
Rnor_6.0823,169,150 - 23,169,337NCBIRnor6.0
Rnor_5.0823,222,471 - 23,222,658UniSTSRnor5.0
Celera822,079,494 - 22,079,681UniSTS
RH 3.4 Map8180.8UniSTS
RH133518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,503,850 - 87,504,030 (+)MAPPERmRatBN7.2
Rnor_6.0488,586,234 - 88,586,413NCBIRnor6.0
Rnor_5.04153,409,109 - 153,409,288UniSTSRnor5.0
RGSC_v3.4487,257,924 - 87,258,103UniSTSRGSC3.4
Celera482,268,768 - 82,268,947UniSTS
RH 3.4 Map4543.3UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078067   ⟹   ENSRNOP00000069790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,965,617 - 28,968,508 (+)Ensembl
mRatBN7.2 Ensembl820,689,502 - 20,692,585 (+)Ensembl
Rnor_6.0 Ensembl823,167,974 - 23,170,209 (+)Ensembl
RefSeq Acc Id: NM_001271975   ⟹   NP_001258904
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,965,634 - 28,967,876 (+)NCBI
mRatBN7.2820,689,621 - 20,691,863 (+)NCBI
Rnor_6.0823,167,974 - 23,170,215 (+)NCBI
Rnor_5.0823,221,295 - 23,223,536 (+)NCBI
Celera822,078,318 - 22,080,559 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78222 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107981
  ENSRNOP00000107981.1
RefSeq Acc Id: NP_001258904   ⟸   NM_001271975
- UniProtKB: A6JNZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069790   ⟸   ENSRNOT00000078067

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7L2-F1-model_v2 AlphaFold M0R7L2 1-71 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695809
Promoter ID:EPDNEW_R6331
Type:initiation region
Name:Pigy_1
Description:phosphatidylinositol glycan anchor biosynthesis, class Y
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0823,167,976 - 23,168,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318067 AgrOrtholog
BioCyc Gene G2FUF-31385 BioCyc
Ensembl Genes ENSRNOG00000052134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078067 ENTREZGENE
  ENSRNOT00000078067.3 UniProtKB/TrEMBL
InterPro PIG-Y UniProtKB/TrEMBL
KEGG Report rno:100365921 UniProtKB/TrEMBL
NCBI Gene 100365921 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Y UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Y UniProtKB/TrEMBL
Pfam PIG-Y UniProtKB/TrEMBL
PhenoGen Pigy PhenoGen
RatGTEx ENSRNOG00000052134 RatGTEx
RNAcentral URS00022B2CDB RNACentral
UniProt A0ABK0M0F7_RAT UniProtKB/TrEMBL
  A6JNZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-21 Pigy  phosphatidylinositol glycan anchor biosynthesis, class Y  LOC100365921  rCG31672-like  Name and Symbol changed 629549 APPROVED
2010-05-05 LOC100365921  rCG31672-like      Symbol and Name status set to provisional 70820 PROVISIONAL