Mir489 (microRNA 489) - Rat Genome Database

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Gene: Mir489 (microRNA 489) Rattus norvegicus
Analyze
Symbol: Mir489
Name: microRNA 489
RGD ID: 2314886
Description: Predicted to act upstream of or within cellular response to leukemia inhibitory factor; miRNA-mediated post-transcriptional gene silencing; and myoblast differentiation involved in skeletal muscle regeneration. Orthologous to human MIR489 (microRNA 489); INTERACTS WITH 6-propyl-2-thiouracil; aristolochic acid A; bis(2-ethylhexyl) phthalate.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-489; rno-mir-489
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,648,039 - 32,648,144 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2431,693,355 - 31,693,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl431,693,355 - 31,693,460 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx436,666,067 - 36,666,172 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,592,177 - 32,592,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0430,951,670 - 30,951,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,659,523 - 28,659,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,659,523 - 28,659,628 (-)Ensemblrn6Rnor6.0
Rnor_5.0428,564,161 - 28,564,266 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4428,518,260 - 28,518,365 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera427,079,905 - 27,080,010 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:20403161   PMID:20439489   PMID:22358842   PMID:31378911   PMID:32144602   PMID:32880387   PMID:34914969   PMID:35304174  


Genomics

Comparative Map Data
Mir489
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,648,039 - 32,648,144 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2431,693,355 - 31,693,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl431,693,355 - 31,693,460 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx436,666,067 - 36,666,172 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,592,177 - 32,592,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0430,951,670 - 30,951,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,659,523 - 28,659,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,659,523 - 28,659,628 (-)Ensemblrn6Rnor6.0
Rnor_5.0428,564,161 - 28,564,266 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4428,518,260 - 28,518,365 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera427,079,905 - 27,080,010 (-)NCBICelera
Cytogenetic Map4q13NCBI
MIR489
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38793,483,936 - 93,484,019 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl793,483,936 - 93,484,019 (-)Ensemblhg38GRCh38
GRCh37793,113,248 - 93,113,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,951,183 - 92,951,266 (-)NCBIBuild 36Build 36hg18NCBI36
Celera787,817,753 - 87,817,836 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef787,724,023 - 87,724,106 (-)NCBIHuRef
CHM1_1793,043,239 - 93,043,322 (-)NCBICHM1_1
T2T-CHM13v2.0794,726,396 - 94,726,479 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2792,442,558 - 92,442,641 (-)NCBI
Mir489
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3963,721,897 - 3,722,003 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl63,721,897 - 3,722,003 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3863,721,897 - 3,722,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl63,721,897 - 3,722,003 (-)Ensemblmm10GRCm38
MGSCv3763,671,897 - 3,672,003 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera63,874,416 - 3,874,522 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.81NCBI
MIR489
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,980,180 - 18,980,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,980,180 - 18,980,263 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1418,539,043 - 18,539,126 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01418,787,216 - 18,787,299 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1418,787,216 - 18,787,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11418,946,098 - 18,946,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01418,681,874 - 18,681,957 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,932,529 - 18,932,612 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR489
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl973,330,690 - 73,330,770 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1973,330,690 - 73,330,770 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2980,161,824 - 80,161,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir489
1 total Variants
miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:4931
Count of gene targets:3646
Count of transcripts:3897
Interacting mature miRNAs:rno-miR-489-3p, rno-miR-489-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
2 2

Sequence


Ensembl Acc Id: ENSRNOT00000054394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl431,693,355 - 31,693,460 (-)Ensembl
Rnor_6.0 Ensembl428,659,523 - 28,659,628 (-)Ensembl
RefSeq Acc Id: NR_032105
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8432,648,039 - 32,648,144 (-)NCBI
mRatBN7.2431,693,355 - 31,693,460 (-)NCBI
Rnor_6.0428,659,523 - 28,659,628 (-)NCBI
Rnor_5.0428,564,161 - 28,564,266 (-)NCBI
RGSC_v3.4428,518,260 - 28,518,365 (-)RGD
Celera427,079,905 - 27,080,010 (-)RGD
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2314886 AgrOrtholog
BioCyc Gene G2FUF-45731 BioCyc
Ensembl Genes ENSRNOG00000036271 Ensembl
miRBase MI0003477 ENTREZGENE
NCBI Gene 100314071 ENTREZGENE
PhenoGen Mir489 PhenoGen
RatGTEx ENSRNOG00000036271 RatGTEx
RNAcentral URS000075BB94 RNACentral
  URS000075DF50 RNACentral
  URS000075EE66 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-25 Mir489  microRNA 489  Mir489  microRNA mir-489  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-04 Mir489  microRNA mir-489      Symbol and Name status set to provisional 70820 PROVISIONAL