MIR1914 (microRNA 1914) - Rat Genome Database
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Gene: MIR1914 (microRNA 1914) Homo sapiens
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Symbol: MIR1914
Name: microRNA 1914
RGD ID: 2312982
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1914; MIRN1914
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2063,941,465 - 63,941,544 (-)EnsemblGRCh38hg38GRCh38
GRCh382063,941,465 - 63,941,544 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372062,572,818 - 62,572,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera2059,256,678 - 59,256,757 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2059,306,202 - 59,306,281 (-)NCBIHuRef
CHM1_12062,473,429 - 62,473,508 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:18583537   PMID:23535732   PMID:28990086   PMID:31576658  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PTCD1hsa-miR-1914-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TMF1hsa-miR-1914-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:63967
Count of gene targets:19762
Count of transcripts:49063
Interacting mature miRNAs:hsa-miR-1914-3p, hsa-miR-1914-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL118506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000607800
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2063,941,465 - 63,941,544 (-)Ensembl
RefSeq Acc Id: NR_031735
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382063,941,465 - 63,941,544 (-)NCBI
GRCh372062,572,818 - 62,572,897 (-)RGD
Celera2059,256,678 - 59,256,757 (-)RGD
HuRef2059,306,202 - 59,306,281 (-)RGD
CHM1_12062,473,429 - 62,473,508 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.33(chr20:63199020-64277321)x3 copy number gain See cases [RCV000051131] Chr20:63199020..64277321 [GRCh38]
Chr20:61830372..62908674 [GRCh37]
Chr20:61300817..62379118 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:62561794-64277321)x1 copy number loss See cases [RCV000133842] Chr20:62561794..64277321 [GRCh38]
Chr20:61211869..62908674 [GRCh37]
Chr20:60569446..62379118 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.32-13.33(chr20:59041966-64277321)x3 copy number gain See cases [RCV000135805] Chr20:59041966..64277321 [GRCh38]
Chr20:57617021..62908674 [GRCh37]
Chr20:57050416..62379118 [NCBI36]
Chr20:20q13.32-13.33
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:63199020-64277321)x1 copy number loss See cases [RCV000135514] Chr20:63199020..64277321 [GRCh38]
Chr20:61830372..62908674 [GRCh37]
Chr20:61300817..62379118 [NCBI36]
Chr20:20q13.33
likely pathogenic
GRCh38/hg38 20q13.33(chr20:63153963-64277321)x1 copy number loss See cases [RCV000137385] Chr20:63153963..64277321 [GRCh38]
Chr20:61785315..62908674 [GRCh37]
Chr20:61255760..62379118 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:56198032-64277321)x3 copy number gain See cases [RCV000138035] Chr20:56198032..64277321 [GRCh38]
Chr20:54773088..62908674 [GRCh37]
Chr20:54206495..62379118 [NCBI36]
Chr20:20q13.2-13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:61326549-64277326)x3 copy number gain See cases [RCV000139100] Chr20:61326549..64277326 [GRCh38]
Chr20:59901605..62908679 [GRCh37]
Chr20:59335000..62379123 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.31-13.33(chr20:57229415-64273089)x3 copy number gain See cases [RCV000141347] Chr20:57229415..64273089 [GRCh38]
Chr20:55804471..62904442 [GRCh37]
Chr20:55237878..62374886 [NCBI36]
Chr20:20q13.31-13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:62582073-64284202)x1 copy number loss See cases [RCV000141744] Chr20:62582073..64284202 [GRCh38]
Chr20:61179280..62915555 [GRCh37]
Chr20:60589725..62385999 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:63385523-64270639)x3 copy number gain See cases [RCV000141762] Chr20:63385523..64270639 [GRCh38]
Chr20:62016875..62901992 [GRCh37]
Chr20:61487319..62372436 [NCBI36]
Chr20:20q13.33
uncertain significance
GRCh38/hg38 20q13.33(chr20:62663307-64284202)x1 copy number loss See cases [RCV000141676] Chr20:62663307..64284202 [GRCh38]
Chr20:61294659..62915555 [GRCh37]
Chr20:60765104..62385999 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:53236165-64284202)x3 copy number gain See cases [RCV000143584] Chr20:53236165..64284202 [GRCh38]
Chr20:51852704..62915555 [GRCh37]
Chr20:51286111..62385999 [NCBI36]
Chr20:20q13.2-13.33
likely pathogenic
GRCh38/hg38 20q13.33(chr20:63827808-64100279)x3 copy number gain See cases [RCV000050998] Chr20:63827808..64100279 [GRCh38]
Chr20:62459161..62731632 [GRCh37]
Chr20:61929605..62202076 [NCBI36]
Chr20:20q13.33
uncertain significance
GRCh38/hg38 20q13.33(chr20:62545370-64241486)x1 copy number loss See cases [RCV000052769] Chr20:62545370..64241486 [GRCh38]
Chr20:61142577..62872839 [GRCh37]
Chr20:60553022..62343283 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.33(chr20:63441478-64277321)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052772]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052772]|See cases [RCV000052772] Chr20:63441478..64277321 [GRCh38]
Chr20:62072831..62908674 [GRCh37]
Chr20:61543275..62379118 [NCBI36]
Chr20:20q13.33
pathogenic
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR1914 COSMIC
Ensembl Genes ENSG00000284433 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000607800 ENTREZGENE
GTEx ENSG00000284433 GTEx
HGNC ID HGNC:35398 ENTREZGENE
Human Proteome Map MIR1914 Human Proteome Map
miRBase MI0008335 ENTREZGENE
NCBI Gene 100302137 ENTREZGENE
PharmGKB PA164722548 PharmGKB
RNAcentral URS000075A6FE RNACentral
  URS000075C11C RNACentral
  URS000075E34C RNACentral