MIR1247 (microRNA 1247) - Rat Genome Database
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Gene: MIR1247 (microRNA 1247) Homo sapiens
Analyze
Symbol: MIR1247
Name: microRNA 1247
RGD ID: 2312974
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1247; mir-1247; MIRN1247
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,560,287 - 101,560,422 (-)EnsemblGRCh38hg38GRCh38
GRCh3814101,560,287 - 101,560,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714102,026,624 - 102,026,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1482,081,713 - 82,081,848 (-)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1482,209,325 - 82,209,460 (-)NCBIHuRef
CHM1_114101,965,105 - 101,965,240 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:21037258   PMID:24014021   PMID:24785261   PMID:25731699   PMID:25973030   PMID:28460450   PMID:28586038   PMID:29335551   PMID:29768218   PMID:29793538  
PMID:29872024   PMID:30175411   PMID:30249392   PMID:30312173   PMID:30318507   PMID:30378132   PMID:30967263   PMID:31539113   PMID:32131485   PMID:32366555  


Genomics

Comparative Map Data
MIR1247
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,560,287 - 101,560,422 (-)EnsemblGRCh38hg38GRCh38
GRCh3814101,560,287 - 101,560,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714102,026,624 - 102,026,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1482,081,713 - 82,081,848 (-)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1482,209,325 - 82,209,460 (-)NCBIHuRef
CHM1_114101,965,105 - 101,965,240 (-)NCBICHM1_1
Mir1247
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,244,482 - 110,244,563 (-)NCBIGRCm39mm39
GRCm39 Ensembl12110,244,482 - 110,244,563 (-)Ensembl
GRCm3812110,278,048 - 110,278,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,278,048 - 110,278,129 (-)EnsemblGRCm38mm10GRCm38
Celera12111,468,520 - 111,468,601 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI

Position Markers
STS-S79854  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3714102,028,757 - 102,029,043UniSTSGRCh37
Build 3614101,098,510 - 101,098,796RGDNCBI36
Celera1482,083,846 - 82,084,132RGD
Cytogenetic Map14q32UniSTS
HuRef1482,211,107 - 82,211,393UniSTS
GeneMap99-GB4 RH Map14277.83UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RPL35Ahsa-miR-1247-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:40536
Count of gene targets:14514
Count of transcripts:33309
Interacting mature miRNAs:hsa-miR-1247-3p, hsa-miR-1247-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408206
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl14101,560,287 - 101,560,422 (-)Ensembl
RefSeq Acc Id: NR_031649
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,560,287 - 101,560,422 (-)NCBI
GRCh3714102,026,624 - 102,026,759 (-)RGD
Celera1482,081,713 - 82,081,848 (-)RGD
HuRef1482,209,325 - 82,209,460 (-)ENTREZGENE
CHM1_114101,965,105 - 101,965,240 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
NM_001362.3(DIO3):c.574G>A (p.Asp192Asn) single nucleotide variant Malignant melanoma [RCV000062706] Chr14:101562070 [GRCh38]
Chr14:102028407 [GRCh37]
Chr14:101098160 [NCBI36]
Chr14:14q32.31
not provided
NM_001362.3(DIO3):c.536C>T (p.Ala179Val) single nucleotide variant Malignant melanoma [RCV000070424] Chr14:101562032 [GRCh38]
Chr14:102028369 [GRCh37]
Chr14:101098122 [NCBI36]
Chr14:14q32.31
not provided
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q32.31(chr14:101534151-101561708)x3 copy number gain See cases [RCV000052091] Chr14:101534151..101561708 [GRCh38]
Chr14:102000488..102028045 [GRCh37]
Chr14:101070241..101097798 [NCBI36]
Chr14:14q32.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:35313 AgrOrtholog
COSMIC MIR1247 COSMIC
Ensembl Genes ENSG00000283857 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408206 ENTREZGENE
GTEx ENSG00000283857 GTEx
HGNC ID HGNC:35313 ENTREZGENE
Human Proteome Map MIR1247 Human Proteome Map
miRBase MI0006382 ENTREZGENE
NCBI Gene 100302145 ENTREZGENE
PharmGKB PA164722386 PharmGKB
RNAcentral URS000032835F RNACentral
  URS000057DF36 RNACentral
  URS000075C329 RNACentral