MIR1279 (microRNA 1279) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR1279 (microRNA 1279) Homo sapiens
Analyze
Symbol: MIR1279
Name: microRNA 1279
RGD ID: 2312947
HGNC Page HGNC:35357
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1279; MIRN1279
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381269,273,157 - 69,273,218 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1269,273,157 - 69,273,218 (-)EnsemblGRCh38hg38GRCh38
GRCh371269,666,937 - 69,666,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1269,330,773 - 69,330,834 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,716,634 - 66,716,695 (-)NCBIHuRef
CHM1_11269,635,324 - 69,635,385 (-)NCBICHM1_1
T2T-CHM13v2.01269,252,258 - 69,252,319 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:23957009   PMID:27879428  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q15-21.2(chr12:68011417-75383054)x1 copy number loss See cases [RCV000135587] Chr12:68011417..75383054 [GRCh38]
Chr12:68405197..75776834 [GRCh37]
Chr12:66691464..74063101 [NCBI36]
Chr12:12q15-21.2
likely pathogenic|uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q14.3-15(chr12:65445176-71026337)x1 copy number loss See cases [RCV000142445] Chr12:65445176..71026337 [GRCh38]
Chr12:65838956..71420117 [GRCh37]
Chr12:64125223..69706384 [NCBI36]
Chr12:12q14.3-15
pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:6774
Count of gene targets:3503
Count of transcripts:5934
Interacting mature miRNAs:hsa-miR-1279
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


RefSeq Acc Id: ENST00000636976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1269,273,157 - 69,273,218 (-)Ensembl
RefSeq Acc Id: NR_031692
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381269,273,157 - 69,273,218 (-)NCBI
GRCh371269,666,937 - 69,666,998 (-)RGD
Celera1269,330,773 - 69,330,834 (-)RGD
HuRef1266,716,634 - 66,716,695 (-)ENTREZGENE
CHM1_11269,635,324 - 69,635,385 (-)NCBI
T2T-CHM13v2.01269,252,258 - 69,252,319 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1279 COSMIC
Ensembl Genes ENSG00000283476 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000636976 ENTREZGENE
GTEx ENSG00000283476 GTEx
HGNC ID HGNC:35357 ENTREZGENE
Human Proteome Map MIR1279 Human Proteome Map
miRBase MI0006426 ENTREZGENE
NCBI Gene 100302182 ENTREZGENE
PharmGKB PA164722426 PharmGKB
RNAcentral URS000075A375 RNACentral
  URS000075E663 RNACentral