MIR1266 (microRNA 1266) - Rat Genome Database

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Gene: MIR1266 (microRNA 1266) Homo sapiens
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Symbol: MIR1266
Name: microRNA 1266
RGD ID: 2312933
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1266; mir-1266; MIRN1266
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1552,277,117 - 52,277,200 (-)EnsemblGRCh38hg38GRCh38
GRCh381552,277,117 - 52,277,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371552,569,314 - 52,569,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1529,463,780 - 29,463,863 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1529,399,986 - 29,400,069 (-)NCBIHuRef
CHM1_11552,687,274 - 52,687,357 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:21037258   PMID:23034410   PMID:24481448   PMID:25640367   PMID:29917195   PMID:30141307   PMID:30261286   PMID:30556861   PMID:31378882   PMID:31820618  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:54549
Count of gene targets:16211
Count of transcripts:39018
Interacting mature miRNAs:hsa-miR-1266-3p, hsa-miR-1266-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 23 7 17 9 16 11 25 9 3 23 19 8 9
Below cutoff 23 2 8 4 9 5 13 9 11 8 24 20 1 6 7

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408125
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1552,277,117 - 52,277,200 (-)Ensembl
RefSeq Acc Id: NR_031670
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,277,117 - 52,277,200 (-)NCBI
GRCh371552,569,314 - 52,569,397 (-)RGD
Celera1529,463,780 - 29,463,863 (-)RGD
HuRef1529,399,986 - 29,400,069 (-)ENTREZGENE
CHM1_11552,687,274 - 52,687,357 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_018728.3(MYO5C):c.309C>T (p.Ile103=) single nucleotide variant Malignant melanoma [RCV000070824] Chr15:52279013 [GRCh38]
Chr15:52571210 [GRCh37]
Chr15:50358502 [NCBI36]
Chr15:15q21.2
not provided
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1 copy number loss See cases [RCV000135639] Chr15:47460844..52494222 [GRCh38]
Chr15:47753041..52786419 [GRCh37]
Chr15:45540333..50573711 [NCBI36]
Chr15:15q21.1-21.2
pathogenic
GRCh38/hg38 15q21.2-21.3(chr15:51276690-57088386)x1 copy number loss See cases [RCV000136661] Chr15:51276690..57088386 [GRCh38]
Chr15:51568887..57380584 [GRCh37]
Chr15:49356179..55167876 [NCBI36]
Chr15:15q21.2-21.3
pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1 copy number loss See cases [RCV000051619] Chr15:46042302..54195828 [GRCh38]
Chr15:46334500..54488025 [GRCh37]
Chr15:44121792..52275317 [NCBI36]
Chr15:15q21.1-21.3
pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:48695331-53923002)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|See cases [RCV000051620] Chr15:48695331..53923002 [GRCh38]
Chr15:48987528..54215199 [GRCh37]
Chr15:46774820..52002491 [NCBI36]
Chr15:15q21.1-21.3
pathogenic
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1 copy number loss See cases [RCV000051621] Chr15:50864913..59646577 [GRCh38]
Chr15:51157110..59938776 [GRCh37]
Chr15:48944402..57726068 [NCBI36]
Chr15:15q21.2-22.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR1266 COSMIC
Ensembl Genes ENSG00000221052 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408125 ENTREZGENE
GTEx ENSG00000221052 GTEx
HGNC ID HGNC:35334 ENTREZGENE
Human Proteome Map MIR1266 Human Proteome Map
miRBase MI0006403 ENTREZGENE
NCBI Gene 100302202 ENTREZGENE
PharmGKB PA164722411 PharmGKB
RNAcentral URS00005FDCD1 RNACentral
  URS0000759C7A RNACentral
  URS000075C31A RNACentral