MIR1324 (microRNA 1324) - Rat Genome Database
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Gene: MIR1324 (microRNA 1324) Homo sapiens
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Symbol: MIR1324
Name: microRNA 1324
RGD ID: 2312925
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1324; MIRN1324
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl375,630,763 - 75,630,858 (+)EnsemblGRCh38hg38GRCh38
GRCh38375,630,763 - 75,630,858 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37375,679,914 - 75,680,009 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera376,423,649 - 76,423,744 (+)NCBI
Cytogenetic Map3p12.3NCBI
HuRef375,697,015 - 75,697,110 (+)NCBIHuRef
CHM1_1375,634,027 - 75,634,122 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:18230126   PMID:29895226  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:20752
Count of gene targets:8329
Count of transcripts:16358
Interacting mature miRNAs:hsa-miR-1324
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 44 16 107 2 10 56 20 190 1 70 82 2 16 45
Below cutoff 59 28 57 10 17 2 53 30 244 7 49 33 8 22 29

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000640185
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl375,630,763 - 75,630,858 (+)Ensembl
RefSeq Acc Id: NR_031714
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38375,630,763 - 75,630,858 (+)NCBI
GRCh37375,679,914 - 75,680,009 (+)RGD
Celera376,423,649 - 76,423,744 (+)RGD
HuRef375,697,015 - 75,697,110 (+)RGD
CHM1_1375,634,027 - 75,634,122 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p12.3(chr3:75522003-75744122)x1 copy number loss See cases [RCV000136978] Chr3:75522003..75744122 [GRCh38]
Chr3:75571154..75793273 [GRCh37]
Chr3:75653844..75875963 [NCBI36]
Chr3:3p12.3
benign
GRCh38/hg38 3p12.3(chr3:75422685-75744282)x1 copy number loss See cases [RCV000138636] Chr3:75422685..75744282 [GRCh38]
Chr3:75471836..75793433 [GRCh37]
Chr3:75554526..75876123 [NCBI36]
Chr3:3p12.3
likely benign
GRCh38/hg38 3p12.3(chr3:75522003-75654754)x3 copy number gain See cases [RCV000140562] Chr3:75522003..75654754 [GRCh38]
Chr3:75571154..75703905 [GRCh37]
Chr3:75653844..75786595 [NCBI36]
Chr3:3p12.3
benign
GRCh38/hg38 3p14.1-12.3(chr3:68328980-76764319)x3 copy number gain See cases [RCV000140215] Chr3:68328980..76764319 [GRCh38]
Chr3:68378130..76813470 [GRCh37]
Chr3:68460820..76896160 [NCBI36]
Chr3:3p14.1-12.3
likely pathogenic|uncertain significance
GRCh38/hg38 3p14.3-11.1(chr3:57140424-90259960)x1 copy number loss See cases [RCV000139626] Chr3:57140424..90259960 [GRCh38]
Chr3:57174452..90309110 [GRCh37]
Chr3:57149492..90391800 [NCBI36]
Chr3:3p14.3-11.1
pathogenic
GRCh38/hg38 3p13-11.1(chr3:73824871-90453699)x1 copy number loss See cases [RCV000141881] Chr3:73824871..90453699 [GRCh38]
Chr3:73874022..90502849 [GRCh37]
Chr3:73956712..90585539 [NCBI36]
Chr3:3p13-11.1
pathogenic
GRCh38/hg38 3p12.3(chr3:75153221-76021659)x3 copy number gain See cases [RCV000142357] Chr3:75153221..76021659 [GRCh38]
Chr3:75202372..76070810 [GRCh37]
Chr3:75285062..76153500 [NCBI36]
Chr3:3p12.3
likely benign
GRCh38/hg38 3p12.3-11.1(chr3:74649382-89495681)x1 copy number loss See cases [RCV000143665] Chr3:74649382..89495681 [GRCh38]
Chr3:74698533..89544831 [GRCh37]
Chr3:74781223..89627521 [NCBI36]
Chr3:3p12.3-11.1
pathogenic
GRCh38/hg38 3p14.1-12.3(chr3:64761248-78410098)x1 copy number loss See cases [RCV000051512] Chr3:64761248..78410098 [GRCh38]
Chr3:64746924..78459248 [GRCh37]
Chr3:64721964..78541938 [NCBI36]
Chr3:3p14.1-12.3
pathogenic
NR_031714.1(MIR1324):n.-251239_47012del deletion Gestational diabetes mellitus uncontrolled [RCV000161299]|Normal pregnancy [RCV000161295]|Preeclampsia [RCV000161297] Chr3:75379524..75677774 [GRCh38]
Chr3:75428675..75726925 [GRCh37]
Chr3:3p12.3
not provided

Additional Information

Database Acc Id Source(s)
COSMIC MIR1324 COSMIC
Ensembl Genes ENSG00000283894 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000640185 ENTREZGENE
GTEx ENSG00000283894 GTEx
HGNC ID HGNC:35377 ENTREZGENE
Human Proteome Map MIR1324 Human Proteome Map
miRBase MI0006657 ENTREZGENE
NCBI Gene 100302212 ENTREZGENE
PharmGKB PA164722476 PharmGKB
RNAcentral URS000075D73A RNACentral
  URS000075F046 RNACentral

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.