MIR1827 (microRNA 1827) - Rat Genome Database
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Gene: MIR1827 (microRNA 1827) Homo sapiens
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Symbol: MIR1827
Name: microRNA 1827
RGD ID: 2312922
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1827; MIRN1827
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12100,189,884 - 100,189,949 (+)EnsemblGRCh38hg38GRCh38
GRCh3812100,189,884 - 100,189,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712100,583,662 - 100,583,727 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q23.1NCBI
HuRef1297,644,978 - 97,645,043 (+)NCBIHuRef
CHM1_112100,549,334 - 100,549,399 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
radon atom  (EXP)
radon(0)  (EXP)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:18392026   PMID:21676885   PMID:26840028   PMID:28387248  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:42118
Count of gene targets:15962
Count of transcripts:33857
Interacting mature miRNAs:hsa-miR-1827
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system appendage entire extraembryonic component
High
Medium 1 1 1
Low 21 3 38 28 63 28 13 5 3 15 27 22 3 1 1
Below cutoff 2 3 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC010203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000408549
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12100,189,884 - 100,189,949 (+)Ensembl
RefSeq Acc Id: NR_031728
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812100,189,884 - 100,189,949 (+)NCBI
GRCh3712100,583,662 - 100,583,727 (+)RGD
HuRef1297,644,978 - 97,645,043 (+)NCBI
CHM1_112100,549,334 - 100,549,399 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.1-23.2(chr12:97394550-101410225)x3 copy number gain See cases [RCV000137891] Chr12:97394550..101410225 [GRCh38]
Chr12:97788328..101804003 [GRCh37]
Chr12:96312459..100328134 [NCBI36]
Chr12:12q23.1-23.2
likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q23.1(chr12:100058819-100217800)x1 copy number loss See cases [RCV000141336] Chr12:100058819..100217800 [GRCh38]
Chr12:100452597..100611578 [GRCh37]
Chr12:98976728..99135709 [NCBI36]
Chr12:12q23.1
uncertain significance
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic
GRCh38/hg38 12q23.1(chr12:100078579-100273980)x3 copy number gain See cases [RCV000053685] Chr12:100078579..100273980 [GRCh38]
Chr12:100472357..100667758 [GRCh37]
Chr12:98996488..99191889 [NCBI36]
Chr12:12q23.1
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR1827 COSMIC
Ensembl Genes ENSG00000221476 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408549 ENTREZGENE
GTEx ENSG00000221476 GTEx
HGNC ID HGNC:35391 ENTREZGENE
Human Proteome Map MIR1827 Human Proteome Map
miRBase MI0008195 ENTREZGENE
NCBI Gene 100302217 ENTREZGENE
PharmGKB PA164722530 PharmGKB
RNAcentral URS000056215C RNACentral
  URS0000626831 RNACentral