MIR1261 (microRNA 1261) - Rat Genome Database

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Gene: MIR1261 (microRNA 1261) Homo sapiens
Analyze
Symbol: MIR1261
Name: microRNA 1261
RGD ID: 2312913
HGNC Page HGNC:35327
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1261; MIRN1261
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381190,869,121 - 90,869,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1190,869,121 - 90,869,202 (-)EnsemblGRCh38hg38GRCh38
GRCh371190,602,289 - 90,602,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1187,902,969 - 87,903,050 (-)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1186,686,643 - 86,686,724 (-)NCBIHuRef
CHM1_11190,485,370 - 90,485,451 (-)NCBICHM1_1
T2T-CHM13v2.01190,790,370 - 90,790,451 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:22566498   PMID:29842886   PMID:31364003   PMID:32319544  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1		 pathogenic
GRCh38/hg38 11q14.3(chr11:90123486-91218361)x3 copy number gain See cases [RCV000135680] Chr11:90123486..91218361 [GRCh38]
Chr11:89856654..90951529 [GRCh37]
Chr11:89496302..90591177 [NCBI36]
Chr11:11q14.3		 uncertain significance
GRCh38/hg38 11q14.3(chr11:90492596-91725920)x1 copy number loss See cases [RCV000138142] Chr11:90492596..91725920 [GRCh38]
Chr11:90225764..91459086 [GRCh37]
Chr11:89865412..91098734 [NCBI36]
Chr11:11q14.3		 likely benign
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8829
Count of gene targets:4237
Count of transcripts:7394
Interacting mature miRNAs:hsa-miR-1261
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 9 5 16 16 45 16 8 3 4 4 10 7 5 2
Below cutoff 5 1 1 2 4 4 3 1 6 1 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1190,869,121 - 90,869,202 (-)Ensembl
RefSeq Acc Id: NR_031663
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381190,869,121 - 90,869,202 (-)NCBI
GRCh371190,602,289 - 90,602,370 (-)RGD
Celera1187,902,969 - 87,903,050 (-)RGD
HuRef1186,686,643 - 86,686,724 (-)ENTREZGENE
CHM1_11190,485,370 - 90,485,451 (-)NCBI
T2T-CHM13v2.01190,790,370 - 90,790,451 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1261 COSMIC
Ensembl Genes ENSG00000221586 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408659 ENTREZGENE
GTEx ENSG00000221586 GTEx
HGNC ID HGNC:35327 ENTREZGENE
Human Proteome Map MIR1261 Human Proteome Map
miRBase MI0006396 ENTREZGENE
NCBI Gene 100302228 ENTREZGENE
PharmGKB PA164722406 PharmGKB
RNAcentral URS00003975B5 RNACentral
  URS000075992E RNACentral