MIR1226 (microRNA 1226) - Rat Genome Database

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Gene: MIR1226 (microRNA 1226) Homo sapiens
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Symbol: MIR1226
Name: microRNA 1226
RGD ID: 2312911
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1226; mir-1226; MIRN1226
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl347,849,555 - 47,849,629 (+)EnsemblGRCh38hg38GRCh38
GRCh38347,849,555 - 47,849,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37347,891,045 - 47,891,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera347,840,904 - 47,840,978 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef347,946,402 - 47,946,476 (+)NCBIHuRef
CHM1_1347,842,291 - 47,842,365 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17964270   PMID:20514397   PMID:21037258   PMID:29680855   PMID:31399552   PMID:33675995   PMID:34592963  


Genomics

Position Markers
RH69910  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37347,891,371 - 47,891,563UniSTSGRCh37
Build 36347,866,375 - 47,866,567RGDNCBI36
Celera347,841,230 - 47,841,422RGD
Cytogenetic Map3p21.31UniSTS
HuRef347,946,728 - 47,946,920UniSTS
RH99010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37347,891,379 - 47,891,563UniSTSGRCh37
Build 36347,866,383 - 47,866,567RGDNCBI36
Celera347,841,238 - 47,841,422RGD
Cytogenetic Map3p21.31UniSTS
HuRef347,946,736 - 47,946,920UniSTS
GeneMap99-GB4 RH Map3156.66UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ATP6AP1hsa-miR-1226-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MUC1hsa-miR-1226-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI20514397
IGF1Rhsa-miR-1226-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MUC1hsa-miR-1226-3pOncomiRDBexternal_infoNANA20514397

Predicted Targets
Summary Value
Count of predictions:76616
Count of gene targets:20927
Count of transcripts:52516
Interacting mature miRNAs:hsa-miR-1226-3p, hsa-miR-1226-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 45 37 35 4 52 2 92 18 53 10 43 43 3 16 51
Below cutoff 25 28 15 6 21 3 52 34 63 1 12 15 3 23 28

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408658
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl347,849,555 - 47,849,629 (+)Ensembl
RefSeq Acc Id: NR_031595
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38347,849,555 - 47,849,629 (+)NCBI
GRCh37347,891,045 - 47,891,119 (+)RGD
Celera347,840,904 - 47,840,978 (+)RGD
HuRef347,946,402 - 47,946,476 (+)ENTREZGENE
CHM1_1347,842,291 - 47,842,365 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR1226 COSMIC
Ensembl Genes ENSG00000221585 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408658 ENTREZGENE
GTEx ENSG00000221585 GTEx
HGNC ID HGNC:33922 ENTREZGENE
Human Proteome Map MIR1226 Human Proteome Map
miRBase MI0006313 ENTREZGENE
NCBI Gene 100302232 ENTREZGENE
PharmGKB PA164722369 PharmGKB
RNAcentral URS00002971AB RNACentral
  URS000064B9B1 RNACentral
  URS000075EAB0 RNACentral