MIR1281 (microRNA 1281) - Rat Genome Database

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Gene: MIR1281 (microRNA 1281) Homo sapiens
Analyze
Symbol: MIR1281
Name: microRNA 1281
RGD ID: 2312907
HGNC Page HGNC:35359
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1281; MIRN1281
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,092,513 - 41,092,566 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,092,513 - 41,092,566 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,488,517 - 41,488,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera2225,294,880 - 25,294,933 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,452,910 - 24,452,963 (+)NCBIHuRef
CHM1_12241,448,240 - 41,448,293 (+)NCBICHM1_1
T2T-CHM13v2.02241,567,425 - 41,567,478 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:25916817   PMID:27716620   PMID:29663357   PMID:31049960   PMID:31858553   PMID:31884421   PMID:32849308   PMID:34498706   PMID:34982356  


Genomics

Variants

.
Variants in MIR1281
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000022.10:g.(?_41264983)_(41729217_?)dup duplication Nephronophthisis-like nephropathy 1 [RCV000556646] Chr22:40868979..41333213 [GRCh38]
Chr22:41264983..41729217 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q13.1-13.33(chr22:40202014-50735806)x3 copy number gain See cases [RCV000134513] Chr22:40202014..50735806 [GRCh38]
Chr22:40598018..51174234 [GRCh37]
Chr22:38927964..49521100 [NCBI36]
Chr22:22q13.1-13.33		 pathogenic
GRCh38/hg38 22q13.2(chr22:40769910-41360090)x3 copy number gain See cases [RCV000134514] Chr22:40769910..41360090 [GRCh38]
Chr22:41165914..41756094 [GRCh37]
Chr22:39495860..40086040 [NCBI36]
Chr22:22q13.2		 uncertain significance
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33		 pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:37061769-50738932)x3 copy number gain See cases [RCV000051684] Chr22:37061769..50738932 [GRCh38]
Chr22:37457809..51177360 [GRCh37]
Chr22:35787755..49524226 [NCBI36]
Chr22:22q12.3-13.33		 pathogenic
GRCh38/hg38 22q13.2(chr22:40860894-41306006)x3 copy number gain See cases [RCV000050897] Chr22:40860894..41306006 [GRCh38]
Chr22:41256898..41702010 [GRCh37]
Chr22:39586844..40031956 [NCBI36]
Chr22:22q13.2		 uncertain significance
NR_031694.1(MIR1281):n.10C>T single nucleotide variant not provided [RCV001668908] Chr22:41092522 [GRCh38]
Chr22:41488526 [GRCh37]
Chr22:22q13.2		 benign
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:32105
Count of gene targets:14765
Count of transcripts:30842
Interacting mature miRNAs:hsa-miR-1281
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408233
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2241,092,513 - 41,092,566 (+)Ensembl
RefSeq Acc Id: NR_031694
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382241,092,513 - 41,092,566 (+)NCBI
GRCh372241,488,517 - 41,488,570 (+)RGD
Celera2225,294,880 - 25,294,933 (+)RGD
HuRef2224,452,910 - 24,452,963 (+)RGD
CHM1_12241,448,240 - 41,448,293 (+)NCBI
T2T-CHM13v2.02241,567,425 - 41,567,478 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1281 COSMIC
Ensembl Genes ENSG00000284015 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408233 ENTREZGENE
GTEx ENSG00000284015 GTEx
HGNC ID HGNC:35359 ENTREZGENE
Human Proteome Map MIR1281 Human Proteome Map
miRBase MI0006428 ENTREZGENE
NCBI Gene 100302237 ENTREZGENE
PharmGKB PA164722430 PharmGKB
RNAcentral URS000075DF7B RNACentral
  URS000075E7A3 RNACentral