MIR1202 (microRNA 1202) - Rat Genome Database

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Gene: MIR1202 (microRNA 1202) Homo sapiens
Analyze
Symbol: MIR1202
Name: microRNA 1202
RGD ID: 2312896
HGNC Page HGNC:35268
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1202; MIRN1202
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386155,946,797 - 155,946,879 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6155,946,797 - 155,946,879 (+)EnsemblGRCh38hg38GRCh38
GRCh376156,267,931 - 156,268,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera6157,002,408 - 157,002,490 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6153,831,578 - 153,831,660 (+)NCBIHuRef
CHM1_16156,530,249 - 156,530,331 (+)NCBICHM1_1
T2T-CHM13v2.06157,149,117 - 157,149,199 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17989717   PMID:24908571   PMID:25315250   PMID:28440476   PMID:28443461   PMID:29217161   PMID:30558403   PMID:32124161   PMID:32252801   PMID:34428251   PMID:35702784  
PMID:38350611  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q25.2-25.3(chr6:154178964-159020369)x1 copy number loss See cases [RCV000134896] Chr6:154178964..159020369 [GRCh38]
Chr6:154500098..159441401 [GRCh37]
Chr6:154541790..159361389 [NCBI36]
Chr6:6q25.2-25.3		 likely pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26		 pathogenic
GRCh38/hg38 6q25.1-25.3(chr6:150381239-159553952)x1 copy number loss See cases [RCV000139578] Chr6:150381239..159553952 [GRCh38]
Chr6:150702375..159974984 [GRCh37]
Chr6:150744068..159894974 [NCBI36]
Chr6:6q25.1-25.3		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27		 pathogenic
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3(chr6:155869250-156798955)x1 copy number loss See cases [RCV000052208] Chr6:155869250..156798955 [GRCh38]
Chr6:156190384..157120089 [GRCh37]
Chr6:156232076..157161781 [NCBI36]
Chr6:6q25.3		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.1-25.3(chr6:150905553-158511926)x1 copy number loss Coffin-Siris syndrome 1 [RCV003327723] Chr6:150905553..158511926 [GRCh38]
Chr6:6q25.1-25.3		 pathogenic
NC_000006.12:g.(?_150381239)_(159553952_?)del deletion Chromosome 6q24-q25 deletion syndrome [RCV003884000] Chr6:150381239..159553952 [GRCh38]
Chr6:6q25.1-25.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:26727
Count of gene targets:11721
Count of transcripts:23677
Interacting mature miRNAs:hsa-miR-1202
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 20
Low 2 4 4 1 55 12 2 4 3 6 5 1 2 11
Below cutoff 3 2 2 4 3 3 2 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6155,946,797 - 155,946,879 (+)Ensembl
RefSeq Acc Id: NR_031606
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386155,946,797 - 155,946,879 (+)NCBI
GRCh376156,267,931 - 156,268,013 (+)RGD
Celera6157,002,408 - 157,002,490 (+)RGD
HuRef6153,831,578 - 153,831,660 (+)ENTREZGENE
CHM1_16156,530,249 - 156,530,331 (+)NCBI
T2T-CHM13v2.06157,149,117 - 157,149,199 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1202 COSMIC
Ensembl Genes ENSG00000221456 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408529 ENTREZGENE
GTEx ENSG00000221456 GTEx
HGNC ID HGNC:35268 ENTREZGENE
Human Proteome Map MIR1202 Human Proteome Map
miRBase MI0006334 ENTREZGENE
NCBI Gene 100302259 ENTREZGENE
PharmGKB PA164722359 PharmGKB
RNAcentral URS000075E4E5 RNACentral
  URS000075E909 RNACentral