Mthfsl (5, 10-methenyltetrahydrofolate synthetase-like) - Rat Genome Database

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Gene: Mthfsl (5, 10-methenyltetrahydrofolate synthetase-like) Mus musculus
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Symbol: Mthfsl
Name: 5, 10-methenyltetrahydrofolate synthetase-like
RGD ID: 2308490
MGI Page MGI
Description: Predicted to have 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to localize to cytosol and mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ST20-MTHFS (ST20-MTHFS readthrough); PARTICIPATES IN folate mediated one-carbon metabolic pathway; INTERACTS WITH carbon nanotube; thapsigargin; triptonide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 100039707; Gm2382; Gm2388; MGC37660; predicted gene 2388
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39988,567,683 - 88,602,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl988,570,655 - 88,602,349 (-)Ensembl
GRCm38988,685,630 - 88,720,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl988,688,602 - 88,720,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37988,583,443 - 88,614,636 (-)NCBIGRCm37mm9NCBIm37
MGSCv36988,577,770 - 88,614,651 (-)NCBImm8
Celera987,285,814 - 87,287,436 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:23341629  
PMID:24194600   PMID:27626380  


Genomics

Comparative Map Data
Mthfsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39988,567,683 - 88,602,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl988,570,655 - 88,602,349 (-)Ensembl
GRCm38988,685,630 - 88,720,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl988,688,602 - 88,720,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37988,583,443 - 88,614,636 (-)NCBIGRCm37mm9NCBIm37
MGSCv36988,577,770 - 88,614,651 (-)NCBImm8
Celera987,285,814 - 87,287,436 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
ST20-MTHFS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1579,845,150 - 79,923,754 (-)EnsemblGRCh38hg38GRCh38
GRCh381579,843,547 - 79,923,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371580,135,889 - 80,215,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map15q25.1NCBI
HuRef1556,894,007 - 56,973,471 (-)NCBIHuRef
CHM1_11580,252,880 - 80,332,383 (-)NCBICHM1_1

Position Markers
AI119695  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9E3.1UniSTS
Whitehead/MRC_RH9955.88UniSTS
px-31f3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map10A3-A4UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map10C3UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map10B5.1UniSTS
Cytogenetic Map18E4UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map12C2UniSTS
Cytogenetic Map13B2UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map18D3UniSTS
cM Map1060.0UniSTS
cM Map154.6UniSTS
cM Map439.4UniSTS
cM Map1170.0UniSTS
cM Map1336.0UniSTS
cM Map518.2UniSTS
cM Map1229.0UniSTS
cM MapX42.0UniSTS
cM Map1347.01UniSTS
Mthfs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9E3.1UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:72
Interacting mature miRNAs:76
Transcripts:ENSMUST00000113110
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001128601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_379391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_870748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_870749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_870750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000113110   ⟹   ENSMUSP00000108734
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,688,602 - 88,719,813 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185519
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,688,606 - 88,716,210 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186721
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,688,606 - 88,719,581 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186863   ⟹   ENSMUSP00000150907
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,688,692 - 88,719,587 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186975
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,712,873 - 88,716,060 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,693,884 - 88,719,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191235
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl988,703,983 - 88,720,296 (-)Ensembl
RefSeq Acc Id: NM_001128601   ⟹   NP_001122073
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,570,658 - 88,601,851 (-)NCBI
GRCm38988,688,605 - 88,719,798 (-)NCBI
MGSCv37988,583,443 - 88,614,636 (-)RGD
Celera987,292,813 - 87,293,202 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001359992   ⟹   NP_001346921
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,570,658 - 88,601,640 (-)NCBI
GRCm38988,688,605 - 88,719,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510728   ⟹   XP_006510791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,567,696 - 88,601,895 (-)NCBI
GRCm38988,685,643 - 88,719,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510730   ⟹   XP_006510793
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,567,683 - 88,601,874 (-)NCBI
GRCm38988,685,630 - 88,719,821 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242646   ⟹   XP_011240948
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,575,934 - 88,602,373 (-)NCBI
GRCm38988,693,881 - 88,720,320 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154489   ⟹   XP_036010382
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,567,696 - 88,601,895 (-)NCBI
RefSeq Acc Id: XM_036154490   ⟹   XP_036010383
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,575,934 - 88,601,895 (-)NCBI
RefSeq Acc Id: XM_036154491   ⟹   XP_036010384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,570,658 - 88,598,616 (-)NCBI
RefSeq Acc Id: XR_379391
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,570,658 - 88,601,895 (-)NCBI
GRCm38988,688,605 - 88,719,800 (-)NCBI
Sequence:
RefSeq Acc Id: XR_870748
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,567,696 - 88,601,895 (-)NCBI
GRCm38988,685,643 - 88,719,796 (-)NCBI
Sequence:
RefSeq Acc Id: XR_870749
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,570,658 - 88,601,895 (-)NCBI
GRCm38988,688,605 - 88,719,796 (-)NCBI
Sequence:
RefSeq Acc Id: XR_870750
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39988,575,934 - 88,601,895 (-)NCBI
GRCm38988,693,881 - 88,719,796 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001122073   ⟸   NM_001128601
- Peptide Label: isoform 1
- UniProtKB: L7N466 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510793   ⟸   XM_006510730
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006510791   ⟸   XM_006510728
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011240948   ⟸   XM_011242646
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001346921   ⟸   NM_001359992
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000150907   ⟸   ENSMUST00000186863
RefSeq Acc Id: ENSMUSP00000108734   ⟸   ENSMUST00000113110
RefSeq Acc Id: XP_036010382   ⟸   XM_036154489
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036010384   ⟸   XM_036154491
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036010383   ⟸   XM_036154490
- Peptide Label: isoform X1

Promoters
RGD ID:8670394
Promoter ID:EPDNEW_M13227
Type:single initiation site
Name:Mthfsl_2
Description:Mus musculus 5, 10-methenyltetrahydrofolate synthetase-like ,transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13229  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38988,719,324 - 88,719,384EPDNEW
RGD ID:8670398
Promoter ID:EPDNEW_M13229
Type:multiple initiation site
Name:Mthfsl_1
Description:Mus musculus 5, 10-methenyltetrahydrofolate synthetase-like ,transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13227  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38988,719,800 - 88,719,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3780550 AgrOrtholog
Ensembl Genes ENSMUSG00000079427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000108734 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000150907 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000113110 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000186863 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10420 UniProtKB/TrEMBL
InterPro FTHF_cligase UniProtKB/TrEMBL
  FTHF_cligase-like_sf UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
KEGG Report mmu:100039707 UniProtKB/TrEMBL
MGD MGI:3780550 ENTREZGENE
NCBI Gene 100039707 ENTREZGENE
PANTHER PTHR23407:SF1 UniProtKB/TrEMBL
Pfam 5-FTHF_cyc-lig UniProtKB/TrEMBL
PhenoGen Mthfsl PhenoGen
PIRSF FTHF_cligase UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
TIGRFAMs MTHFS_bact UniProtKB/TrEMBL
UniProt L7N466 ENTREZGENE, UniProtKB/TrEMBL
  Q8R1G5_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-28 Mthfsl  5, 10-methenyltetrahydrofolate synthetase-like  Gm2388  predicted gene 2388  Data Merged 737654 PROVISIONAL
2015-01-20 Mthfsl  5, 10-methenyltetrahydrofolate synthetase-like  Gm2382  predicted gene 2382  Symbol and/or name change 5135510 APPROVED