Ndufb4b (NADH:ubiquinone oxidoreductase subunit B4B) - Rat Genome Database

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Gene: Ndufb4b (NADH:ubiquinone oxidoreductase subunit B4B) Mus musculus
Analyze
No known orthologs.
Symbol: Ndufb4b (Ensembl: Ndufb4)
Name: NADH:ubiquinone oxidoreductase subunit B4B (Ensembl:NADH:ubiquinone oxidoreductase subunit B4)
RGD ID: 2308268
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of mitochondrial respiratory chain complex I. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 100042503; Gm3873; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; predicted gene 3873
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391925,010,472 - 25,010,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,467,532 - 37,474,815 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1925,010,493 - 25,010,965 (+)EnsemblGRCm39 Ensembl
GRCm381925,033,108 - 25,033,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,647,170 - 37,654,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371925,107,632 - 25,108,021 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361925,107,612 - 25,108,109 (+)NCBIMGSCv36mm8
Cytogenetic Map19BNCBI
cM Map1919.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30550785   PMID:30562941  


Genomics

Variants

.
Variants in Ndufb4b
29 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1301197Tlyr1_mthymic lymphoma resistance 1 (mouse)Not determined192053952825313796Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse

Markers in Region
Ndufb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381925,033,271 - 25,033,509UniSTSGRCm38
GRCm381573,809,529 - 73,809,767UniSTSGRCm38
MGSCv371925,107,761 - 25,107,999UniSTSGRCm37
MGSCv371573,639,959 - 73,640,197UniSTSGRCm37
Cytogenetic Map15D3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map19BUniSTS
cM Map16 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001478443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023514   ⟹   ENSMUSP00000023514
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,467,532 - 37,474,815 (-)Ensembl
GRCm38.p6 Ensembl1637,647,170 - 37,654,453 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,467,963 - 37,469,721 (-)Ensembl
GRCm38.p6 Ensembl1637,647,601 - 37,649,359 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231881
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,473,796 - 37,474,728 (-)Ensembl
GRCm38.p6 Ensembl1637,653,434 - 37,654,366 (-)Ensembl
RefSeq Acc Id: ENSMUST00000243237
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1925,010,493 - 25,010,965 (+)Ensembl
RefSeq Acc Id: XM_001478443   ⟹   XP_001478493
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391925,010,472 - 25,010,942 (+)NCBI
GRCm381925,033,108 - 25,033,578 (+)NCBI
MGSCv371925,107,632 - 25,108,021 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs XP_001478493 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000023514.4
Reference Protein Sequences
RefSeq Acc Id: XP_001478493   ⟸   XM_001478443
- UniProtKB: Q9CQC7 (UniProtKB/Swiss-Prot),   Q4VAE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000023514   ⟸   ENSMUST00000023514

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQC7-F1-model_v2 AlphaFold Q9CQC7 1-129 view protein structure

Promoters
RGD ID:6830070
Promoter ID:MM_KWN:26713
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:XM_001478443_GM3873
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361925,107,721 - 25,108,221 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3782046 AgrOrtholog
Ensembl Genes ENSMUSG00000022820 Ensembl, UniProtKB/Swiss-Prot
  ENSMUSG00000120425 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000023514.4 UniProtKB/Swiss-Prot
  ENSMUST00000243237 ENTREZGENE
InterPro NADH_UbQ_OxRdtase_NDUFB4_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100042503 UniProtKB/Swiss-Prot
  mmu:68194 UniProtKB/Swiss-Prot
MGD MGI:3782046 ENTREZGENE
NCBI Gene 100042503 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam NDUF_B4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufb4b PhenoGen
UniProt NDUB4_MOUSE UniProtKB/Swiss-Prot
  Q4VAE8 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQC7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Ndufb4b  NADH:ubiquinone oxidoreductase subunit B4B  Gm3873  predicted gene 3873  Symbol and/or name change 5135510 APPROVED