Fbxw28 (F-box and WD-40 domain protein 28) - Rat Genome Database

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Gene: Fbxw28 (F-box and WD-40 domain protein 28) Mus musculus
Analyze
No known orthologs.
Symbol: Fbxw28
Name: F-box and WD-40 domain protein 28
RGD ID: 2307947
MGI Page MGI
Description: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and WD-40 domain protein 14-like; Gm9337
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,151,862 - 109,168,727 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,151,954 - 109,168,727 (-)EnsemblGRCm39 Ensembl
GRCm389109,322,794 - 109,339,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,322,886 - 109,339,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,225,400 - 109,242,173 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,180,293 - 109,197,065 (-)NCBIMGSCv36mm8
Cytogenetic Map9F2NCBI
cM Map959.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Variants

.
Variants in Fbxw28
560 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:144
Interacting mature miRNAs:150
Transcripts:ENSMUST00000112039, ENSMUST00000112040
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000112039   ⟹   ENSMUSP00000107670
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,152,302 - 109,168,727 (-)Ensembl
GRCm38.p6 Ensembl9109,323,234 - 109,339,659 (-)Ensembl
RefSeq Acc Id: ENSMUST00000112040   ⟹   ENSMUSP00000107671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,151,954 - 109,168,727 (-)Ensembl
GRCm38.p6 Ensembl9109,322,886 - 109,339,659 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196351   ⟹   ENSMUSP00000143357
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,159,910 - 109,168,710 (-)Ensembl
GRCm38.p6 Ensembl9109,330,842 - 109,339,642 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200156   ⟹   ENSMUSP00000143361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,152,305 - 109,168,722 (-)Ensembl
GRCm38.p6 Ensembl9109,323,237 - 109,339,654 (-)Ensembl
RefSeq Acc Id: NM_001177419   ⟹   NP_001170890
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,151,954 - 109,168,727 (-)NCBI
GRCm389109,322,886 - 109,339,659 (-)NCBI
MGSCv379109,225,400 - 109,242,173 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177420   ⟹   NP_001170891
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,152,306 - 109,168,727 (-)NCBI
GRCm389109,323,238 - 109,339,659 (-)NCBI
MGSCv379109,225,400 - 109,242,173 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512211   ⟹   XP_006512274
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,151,862 - 109,168,722 (-)NCBI
GRCm389109,322,794 - 109,339,654 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001170890   ⟸   NM_001177419
- Peptide Label: isoform 1
- UniProtKB: Q3UPQ4 (UniProtKB/TrEMBL),   B9EHJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001170891   ⟸   NM_001177420
- Peptide Label: isoform 2
- UniProtKB: E9Q8A4 (UniProtKB/TrEMBL),   B9EHJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512274   ⟸   XM_006512211
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JFZ2 (UniProtKB/TrEMBL),   B7ZN94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107670   ⟸   ENSMUST00000112039
RefSeq Acc Id: ENSMUSP00000107671   ⟸   ENSMUST00000112040
RefSeq Acc Id: ENSMUSP00000143357   ⟸   ENSMUST00000196351
RefSeq Acc Id: ENSMUSP00000143361   ⟸   ENSMUST00000200156
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q8A4-F1-model_v2 AlphaFold E9Q8A4 1-466 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3779847 AgrOrtholog
Ensembl Genes ENSMUSG00000054087 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112039 ENTREZGENE
  ENSMUST00000112039.7 UniProtKB/TrEMBL
  ENSMUST00000112040 ENTREZGENE
  ENSMUST00000112040.9 UniProtKB/TrEMBL
  ENSMUST00000196351.2 UniProtKB/TrEMBL
  ENSMUST00000200156 ENTREZGENE
  ENSMUST00000200156.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report mmu:668758 UniProtKB/TrEMBL
MGD MGI:3779847 ENTREZGENE
NCBI Gene 668758 ENTREZGENE
PANTHER EXPRESSED SEQUENCE C85627-RELATED UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxw28 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JFY8_MOUSE UniProtKB/TrEMBL
  A0A0G2JFZ2 ENTREZGENE, UniProtKB/TrEMBL
  B7ZN94 ENTREZGENE
  B9EHJ2 ENTREZGENE
  E9Q8A4 ENTREZGENE, UniProtKB/TrEMBL
  Q3TS95_MOUSE UniProtKB/TrEMBL
  Q3UPQ4 ENTREZGENE, UniProtKB/TrEMBL