Topaz1 (testis and ovary specific PAZ domain containing 1) - Rat Genome Database
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Gene: Topaz1 (testis and ovary specific PAZ domain containing 1) Mus musculus
Analyze
Symbol: Topaz1
Name: testis and ovary specific PAZ domain containing 1
RGD ID: 2306857
MGI Page MGI
Description: Involved in several processes, including pachytene; positive regulation of meiotic cell cycle phase transition; and spermatogenesis. Predicted to localize to cytoplasm. Is expressed in germ cell of testis; ovary; and testis. Orthologous to human TOPAZ1 (testis and ovary specific PAZ domain containing 1); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; PCB138.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 671232; gene model 591, (NCBI); Gm591; Gm847; Gm9524; hypothetical protein LOC671232; predicted gene 847; predicted gene 9524; testis and ovary-specific PAZ domain gene 1; testis- and ovary-specific PAZ domain-containing protein 1; topaz 1; uncharacterized protein LOC671232
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,576,264 - 122,631,200 (+)NCBIGRCm39mm39
GRCm389122,747,199 - 122,802,135 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,747,346 - 122,802,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,656,464 - 122,711,253 (+)NCBIGRCm37mm9NCBIm37
MGSCv369122,680,835 - 122,711,253 (+)NCBImm8
Celera9123,196,291 - 123,251,031 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10922068   PMID:21873635   PMID:22069478   PMID:26358182   PMID:32325033  


Genomics

Comparative Map Data
Topaz1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,576,264 - 122,631,200 (+)NCBIGRCm39mm39
GRCm389122,747,199 - 122,802,135 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,747,346 - 122,802,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,656,464 - 122,711,253 (+)NCBIGRCm37mm9NCBIm37
MGSCv369122,680,835 - 122,711,253 (+)NCBImm8
Celera9123,196,291 - 123,251,031 (+)NCBICelera
Cytogenetic Map9F4NCBI
TOPAZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl344,241,886 - 44,332,098 (+)EnsemblGRCh38hg38GRCh38
GRCh38344,241,886 - 44,337,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37344,283,378 - 44,373,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,258,382 - 44,348,594 (+)NCBINCBI36hg18NCBI36
Celera344,221,424 - 44,311,638 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef344,326,973 - 44,417,182 (+)NCBIHuRef
CHM1_1344,233,507 - 44,323,686 (+)NCBICHM1_1
Topaz1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08131,788,816 - 131,843,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,789,575 - 131,843,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08130,944,799 - 130,998,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,448,509 - 127,502,514 (+)NCBIRGSC3.4rn4RGSC3.4
Celera8121,473,442 - 121,530,654 (+)NCBICelera
Cytogenetic Map8q32NCBI
Topaz1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542027,048,713 - 27,107,006 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542027,048,650 - 27,106,983 (-)NCBIChiLan1.0ChiLan1.0
TOPAZ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1345,190,901 - 45,280,601 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl345,190,960 - 45,280,601 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0344,131,729 - 44,221,846 (+)NCBIMhudiblu_PPA_v0panPan3
TOPAZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl232,009,613 - 2,086,697 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1232,009,526 - 2,086,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Topaz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366951,137,867 - 1,206,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOPAZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,574,767 - 27,643,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11327,574,718 - 27,644,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOPAZ1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,665,735 - 5,757,697 (+)NCBI
ChlSab1.1 Ensembl225,666,215 - 5,757,697 (+)Ensembl
Topaz1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473076,011,384 - 76,083,927 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSMUST00000178679
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000178679   ⟹   ENSMUSP00000136304
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9122,747,346 - 122,802,135 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213519
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9122,750,603 - 122,771,322 (+)Ensembl
RefSeq Acc Id: NM_001199736   ⟹   NP_001186665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399122,576,264 - 122,631,200 (+)NCBI
GRCm389122,747,199 - 122,802,135 (+)NCBI
Celera9123,196,291 - 123,250,970 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001186665 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADK36691 (Get FASTA)   NCBI Sequence Viewer  
  E5FYH1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001186665   ⟸   NM_001199736
- UniProtKB: E5FYH1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136304   ⟸   ENSMUST00000178679

Promoters
RGD ID:8671304
Promoter ID:EPDNEW_M13682
Type:multiple initiation site
Name:Topaz1_1
Description:Mus musculus testis and ovary specific PAZ domain containing1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389122,747,319 - 122,747,379EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3779933 AgrOrtholog
Ensembl Genes ENSMUSG00000094985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000136304 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000178679 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TOPAZ1 UniProtKB/Swiss-Prot
  TOPAZ1_dom UniProtKB/Swiss-Prot
KEGG Report mmu:671232 UniProtKB/Swiss-Prot
MGD MGI:3779933 ENTREZGENE
NCBI Gene 671232 ENTREZGENE
PANTHER PTHR35671 UniProtKB/Swiss-Prot
Pfam Asp_Glu_race_2 UniProtKB/Swiss-Prot
PhenoGen Topaz1 PhenoGen
UniGene Mm.296421 ENTREZGENE
UniProt E5FYH1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-21 Topaz1  testis and ovary specific PAZ domain containing 1  Gm847  predicted gene 847  Data Merged 737654 PROVISIONAL
2016-04-01 Topaz1  testis and ovary specific PAZ domain containing 1  Gm591  gene model 591, (NCBI)  Data Merged 737654 PROVISIONAL
2012-12-25 Topaz1  testis and ovary specific PAZ domain containing 1  Gm9524  predicted gene 9524  Symbol and/or name change 5135510 APPROVED