TRL-AAG1-1 (tRNA-Leu (anticodon AAG) 1-1) - Rat Genome Database

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Gene: TRL-AAG1-1 (tRNA-Leu (anticodon AAG) 1-1) Homo sapiens
Analyze
Symbol: TRL-AAG1-1
Name: tRNA-Leu (anticodon AAG) 1-1
RGD ID: 2300615
HGNC Page HGNC:34930
Description:
Type: trna
RefSeq Status: MODEL
Previously known as: transfer RNA-Leu (AAG) 1-1; tRNA-Leu (AAG) 1-1; TRNAL34
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385181,097,474 - 181,097,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375180,524,474 - 180,524,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map5q35.3NCBI
HuRef5175,251,611 - 175,251,692 (-)NCBIHuRef
CHM1_15179,955,122 - 179,955,203 (-)NCBICHM1_1
T2T-CHM13v2.05181,657,108 - 181,657,189 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:18984615  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:164386701-181269805)x3 copy number gain See cases [RCV000135546] Chr5:164386701..181269805 [GRCh38]
Chr5:163813707..180696806 [GRCh37]
Chr5:163746285..180629412 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.3(chr5:180636182-181269805)x3 copy number gain See cases [RCV000136903] Chr5:180636182..181269805 [GRCh38]
Chr5:180063182..180696806 [GRCh37]
Chr5:179995788..180629412 [NCBI36]
Chr5:5q35.3		 uncertain significance
GRCh38/hg38 5q35.1-35.3(chr5:169334755-181285301)x3 copy number gain See cases [RCV000141249] Chr5:169334755..181285301 [GRCh38]
Chr5:168761759..180712302 [GRCh37]
Chr5:168694337..180644908 [NCBI36]
Chr5:5q35.1-35.3		 pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:175536771-181292788)x1 copy number loss See cases [RCV000141987] Chr5:175536771..181292788 [GRCh38]
Chr5:174963774..180719789 [GRCh37]
Chr5:174896380..180652395 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.3(chr5:178235909-181292788)x3 copy number gain See cases [RCV000142298] Chr5:178235909..181292788 [GRCh38]
Chr5:177662910..180719789 [GRCh37]
Chr5:177595516..180652395 [NCBI36]
Chr5:5q35.3		 likely pathogenic
GRCh38/hg38 5q35.2-35.3(chr5:176700128-181269805)x1 copy number loss See cases [RCV000142648] Chr5:176700128..181269805 [GRCh38]
Chr5:176127129..180696806 [GRCh37]
Chr5:176059735..180629412 [NCBI36]
Chr5:5q35.2-35.3		 pathogenic
GRCh38/hg38 5q35.3(chr5:178529878-181269805)x3 copy number gain See cases [RCV000051205] Chr5:178529878..181269805 [GRCh38]
Chr5:177956879..180696806 [GRCh37]
Chr5:177889485..180629412 [NCBI36]
Chr5:5q35.3		 uncertain significance
GRCh38/hg38 5q35.3(chr5:181033562-181131973)x3 copy number gain See cases [RCV000051212] Chr5:181033562..181131973 [GRCh38]
Chr5:180460562..180558973 [GRCh37]
Chr5:180393168..180491579 [NCBI36]
Chr5:5q35.3		 benign
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:168689326-181269946)x3 copy number gain See cases [RCV000051866] Chr5:168689326..181269946 [GRCh38]
Chr5:168116331..180696947 [GRCh37]
Chr5:168048909..180629553 [NCBI36]
Chr5:5q34-35.3		 pathogenic

Expression


Sequence



Additional Information

Database Acc Id Source(s)
COSMIC TRL-AAG1-1 COSMIC
GTEx TRL-AAG1-1 GTEx
HGNC ID HGNC:34930 ENTREZGENE
Human Proteome Map TRL-AAG1-1 Human Proteome Map
NCBI Gene 100189362 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 TRL-AAG1-1  tRNA-Leu (anticodon AAG) 1-1    tRNA-Leu (AAG) 1-1  Symbol and/or name change 5135510 APPROVED
2018-11-29 TRL-AAG1-1  tRNA-Leu (AAG) 1-1    transfer RNA-Leu (AAG) 1-1  Symbol and/or name change 5135510 APPROVED
2014-06-24 TRL-AAG1-1  transfer RNA-Leu (AAG) 1-1  TRNAL34  transfer RNA leucine 34 (anticodon AAG)  Symbol and/or name change 5135510 APPROVED