MIR668 (microRNA 668) - Rat Genome Database

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Gene: MIR668 (microRNA 668) Homo sapiens
Analyze
Symbol: MIR668
Name: microRNA 668
RGD ID: 2290266
HGNC Page HGNC
Description: Predicted to act upstream of or within with a negative effect on apoptotic process and gene expression. Predicted to act upstream of or within cellular response to hypoxia; gene silencing by miRNA; and mitochondrion organization.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-668; MIRN668
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,055,258 - 101,055,323 (+)EnsemblGRCh38hg38GRCh38
GRCh3814101,055,258 - 101,055,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,521,595 - 101,521,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,591,347 - 100,591,412 (+)NCBINCBI36hg18NCBI36
Celera1481,577,656 - 81,577,721 (+)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1481,704,968 - 81,705,033 (+)NCBIHuRef
CHM1_114101,460,617 - 101,460,682 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

Additional References at PubMed
PMID:16381832   PMID:16954537   PMID:23034410   PMID:28138801   PMID:30325740  


Genomics

Comparative Map Data
MIR668
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,055,258 - 101,055,323 (+)EnsemblGRCh38hg38GRCh38
GRCh3814101,055,258 - 101,055,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,521,595 - 101,521,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,591,347 - 100,591,412 (+)NCBINCBI36hg18NCBI36
Celera1481,577,656 - 81,577,721 (+)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1481,704,968 - 81,705,033 (+)NCBIHuRef
CHM1_114101,460,617 - 101,460,682 (+)NCBICHM1_1
Mir668
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,701,166 - 109,701,231 (+)NCBIGRCm39mm39
GRCm39 Ensembl12109,701,166 - 109,701,231 (+)Ensembl
GRCm3812109,734,732 - 109,734,797 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,734,732 - 109,734,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,972,942 - 110,973,007 (+)NCBIGRCm37mm9NCBIm37
Celera12110,931,963 - 110,932,028 (+)NCBICelera
Cytogenetic Map12F1NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:28079
Count of gene targets:12602
Count of transcripts:25086
Interacting mature miRNAs:hsa-miR-668-3p, hsa-miR-668-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 1
Low 7 14 17 1 11 1 22 9 35 12 16 4 12 2
Below cutoff 1 7 5 3 7 9 25 4 4 3 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_030408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL132709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000611970
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl14101,055,258 - 101,055,323 (+)Ensembl
RefSeq Acc Id: NR_030408
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,055,258 - 101,055,323 (+)NCBI
GRCh3714101,521,595 - 101,521,660 (+)RGD
Celera1481,577,656 - 81,577,721 (+)RGD
HuRef1481,704,968 - 81,705,033 (+)ENTREZGENE
CHM1_114101,460,617 - 101,460,682 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33135 AgrOrtholog
COSMIC MIR668 COSMIC
Ensembl Genes ENSG00000276352 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000611970 ENTREZGENE
GTEx ENSG00000276352 GTEx
HGNC ID HGNC:33135 ENTREZGENE
Human Proteome Map MIR668 Human Proteome Map
miRBase MI0003761 ENTREZGENE
NCBI Gene 768214 ENTREZGENE
PharmGKB PA164722963 PharmGKB
RNAcentral URS00006F5B1B RNACentral
  URS000075A144 RNACentral
  URS000075C6C5 RNACentral