MIR298 (microRNA 298) - Rat Genome Database

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Gene: MIR298 (microRNA 298) Homo sapiens
Analyze
Symbol: MIR298
Name: microRNA 298
RGD ID: 2290256
HGNC Page HGNC
Description: Predicted to act upstream of or within cellular response to leukemia inhibitory factor and sensory perception of sound. Predicted to be part of RISC complex.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-298; MIRN298
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2058,818,226 - 58,818,313 (-)EnsemblGRCh38hg38GRCh38
GRCh382058,818,226 - 58,818,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,393,281 - 57,393,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,826,675 - 56,826,762 (-)NCBINCBI36hg18NCBI36
Celera2054,133,741 - 54,133,828 (-)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,179,702 - 54,179,789 (-)NCBIHuRef
CHM1_12057,294,921 - 57,295,008 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
RISC complex  (ISO)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20190813   PMID:22521303   PMID:29172698   PMID:29990836   PMID:30133116   PMID:30394665   PMID:30935924   PMID:31621072   PMID:31942037  


Genomics

Comparative Map Data
MIR298
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2058,818,226 - 58,818,313 (-)EnsemblGRCh38hg38GRCh38
GRCh382058,818,226 - 58,818,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,393,281 - 57,393,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,826,675 - 56,826,762 (-)NCBINCBI36hg18NCBI36
Celera2054,133,741 - 54,133,828 (-)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,179,702 - 54,179,789 (-)NCBIHuRef
CHM1_12057,294,921 - 57,295,008 (-)NCBICHM1_1
Mir298
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,109,297 - 174,109,378 (-)NCBIGRCm39mm39
GRCm39 Ensembl2174,109,297 - 174,109,378 (-)Ensembl
GRCm382174,267,504 - 174,267,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,267,504 - 174,267,585 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,093,005 - 174,093,086 (-)NCBIGRCm37mm9NCBIm37
Celera2180,232,502 - 180,232,583 (-)NCBICelera
Cytogenetic Map2H4NCBI
Mir298
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,052,291 - 163,052,372 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3163,052,291 - 163,052,372 (-)Ensembl
Rnor_6.03172,357,943 - 172,358,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,357,943 - 172,358,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,409,241 - 178,409,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,227,403 - 162,227,484 (-)NCBICelera
Cytogenetic Map3q43NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BACE1hsa-miR-298Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18642050
CDKN1Ahsa-miR-298Mirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20190813
ABCB1hsa-miR-298OncomiRDBexternal_infoNANA22521303

Predicted Targets
Summary Value
Count of predictions:29018
Count of gene targets:10228
Count of transcripts:21071
Interacting mature miRNAs:hsa-miR-298
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 3 2 2 9 1 1
Low 49 24 48 10 236 12 186 37 82 44 113 119 1 1 10
Below cutoff 28 16 16 3 21 3 29 13 20 7 22 21 1 6 10 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000401212
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2058,818,226 - 58,818,313 (-)Ensembl
RefSeq Acc Id: NR_030580
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382058,818,226 - 58,818,313 (-)NCBI
GRCh372057,393,281 - 57,393,368 (-)RGD
Celera2054,133,741 - 54,133,828 (-)RGD
HuRef2054,179,702 - 54,179,789 (-)ENTREZGENE
CHM1_12057,294,921 - 57,295,008 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:55630597-60941207)x3 copy number gain See cases [RCV000135622] Chr20:55630597..60941207 [GRCh38]
Chr20:54220678..59516263 [GRCh37]
Chr20:53639062..58949658 [NCBI36]
Chr20:20q13.2-13.33
likely pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:56198032-64277321)x3 copy number gain See cases [RCV000138035] Chr20:56198032..64277321 [GRCh38]
Chr20:54773088..62908674 [GRCh37]
Chr20:54206495..62379118 [NCBI36]
Chr20:20q13.2-13.33
pathogenic
GRCh38/hg38 20q13.31-13.33(chr20:57229415-64273089)x3 copy number gain See cases [RCV000141347] Chr20:57229415..64273089 [GRCh38]
Chr20:55804471..62904442 [GRCh37]
Chr20:55237878..62374886 [NCBI36]
Chr20:20q13.31-13.33
pathogenic
GRCh38/hg38 20q13.32(chr20:58630473-58881669)x3 copy number gain See cases [RCV000141642] Chr20:58630473..58881669 [GRCh38]
Chr20:57205529..57456724 [GRCh37]
Chr20:56638935..56890119 [NCBI36]
Chr20:20q13.32
uncertain significance
GRCh38/hg38 20q13.2-13.33(chr20:53236165-64284202)x3 copy number gain See cases [RCV000143584] Chr20:53236165..64284202 [GRCh38]
Chr20:51852704..62915555 [GRCh37]
Chr20:51286111..62385999 [NCBI36]
Chr20:20q13.2-13.33
likely pathogenic
GRCh37/hg19 20q13.2-13.33(chr20:51542616-62915555)x3 copy number gain See cases [RCV000511980] Chr20:51542616..62915555 [GRCh37]
Chr20:20q13.2-13.33
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20q13.2-13.33(chr20:54143747-62194881) copy number gain not provided [RCV000767669] Chr20:54143747..62194881 [GRCh37]
Chr20:20q13.2-13.33
pathogenic
NC_000020.10:g.(?_56993257)_(57967907_?)dup duplication Amyotrophic lateral sclerosis type 8 [RCV000821283] Chr20:56993257..57967907 [GRCh37]
Chr20:20q13.32
uncertain significance
GRCh37/hg19 20q13.31-13.33(chr20:55743522-62032989)x3 copy number gain not provided [RCV001007097] Chr20:55743522..62032989 [GRCh37]
Chr20:20q13.31-13.33
pathogenic
GRCh37/hg19 20q13.32-13.33(chr20:56788101-62762405)x3 copy number gain not provided [RCV001007098] Chr20:56788101..62762405 [GRCh37]
Chr20:20q13.32-13.33
pathogenic
GRCh37/hg19 20q13.2-13.33(chr20:51799648-62916626)x3 copy number gain not provided [RCV001537917] Chr20:51799648..62916626 [GRCh37]
Chr20:20q13.2-13.33
pathogenic
NC_000020.10:g.(?_56993257)_(57967907_?)dup duplication Amyotrophic lateral sclerosis type 8 [RCV001324796] Chr20:56993257..57967907 [GRCh37]
Chr20:20q13.32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33634 AgrOrtholog
COSMIC MIR298 COSMIC
Ensembl Genes ENSG00000216031 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000401212 ENTREZGENE
GTEx ENSG00000216031 GTEx
HGNC ID HGNC:33634 ENTREZGENE
Human Proteome Map MIR298 Human Proteome Map
miRBase MI0005523 ENTREZGENE
NCBI Gene 100126296 ENTREZGENE
OMIM 614914 OMIM
PharmGKB PA164722626 PharmGKB
RNAcentral URS000069C337 RNACentral
  URS000075E8F5 RNACentral