MIR877 (microRNA 877) - Rat Genome Database

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Gene: MIR877 (microRNA 877) Homo sapiens
Analyze
Symbol: MIR877
Name: microRNA 877
RGD ID: 2290241
HGNC Page HGNC
Description: Predicted to act upstream of or within cell aging.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-877; mir-877; MIRN877; miRNA877
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl630,584,332 - 30,584,417 (+)EnsemblGRCh38hg38GRCh38
GRCh38630,584,332 - 30,584,417 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37630,552,109 - 30,552,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,660,087 - 30,660,172 (+)NCBINCBI36hg18NCBI36
Celera632,150,226 - 32,150,311 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef630,352,183 - 30,352,268 (+)NCBIHuRef
CHM1_1630,554,223 - 30,554,308 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell aging  (ISO)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16954537   PMID:17604727   PMID:17964270   PMID:21037258   PMID:25973036   PMID:26646931   PMID:27429046   PMID:27542871   PMID:31196742   PMID:31737900   PMID:31811909  
PMID:31957850   PMID:32113822   PMID:32513696   PMID:32543927   PMID:32853022   PMID:32977766   PMID:32981678   PMID:33721456   PMID:33735715   PMID:34254950  


Genomics

Comparative Map Data
MIR877
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl630,584,332 - 30,584,417 (+)EnsemblGRCh38hg38GRCh38
GRCh38630,584,332 - 30,584,417 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37630,552,109 - 30,552,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,660,087 - 30,660,172 (+)NCBINCBI36hg18NCBI36
Celera632,150,226 - 32,150,311 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef630,352,183 - 30,352,268 (+)NCBIHuRef
CHM1_1630,554,223 - 30,554,308 (+)NCBICHM1_1
Mir877
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,271,622 - 36,271,706 (-)NCBIGRCm39mm39
GRCm39 Ensembl1736,271,622 - 36,271,706 (-)Ensembl
GRCm381735,960,730 - 35,960,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,960,730 - 35,960,814 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,097,675 - 36,097,759 (-)NCBIGRCm37mm9NCBIm37
Celera1739,474,255 - 39,474,339 (-)NCBICelera
Cytogenetic Map17B1NCBI
Mir877
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2202,811,476 - 2,811,560 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl202,811,476 - 2,811,560 (+)Ensembl
Rnor_6.0203,318,872 - 3,318,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,318,872 - 3,318,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,416,400 - 5,416,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera20237,323 - 237,407 (+)NCBICelera
Cytogenetic Map20p12NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RPLP1hsa-miR-877-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
SLC6A8hsa-miR-877-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:47036
Count of gene targets:14661
Count of transcripts:32283
Interacting mature miRNAs:hsa-miR-877-3p, hsa-miR-877-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 2 1 10 2 9 1 2 8
Low 311 350 318 27 236 12 648 190 434 21 239 420 18 204 421
Below cutoff 328 316 186 58 206 25 401 303 427 27 147 153 33 148 264

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000401282
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,584,332 - 30,584,417 (+)Ensembl
RefSeq Acc Id: NR_030615
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,584,332 - 30,584,417 (+)NCBI
GRCh37630,552,109 - 30,552,194 (+)RGD
Celera632,150,226 - 32,150,311 (+)RGD
HuRef630,352,183 - 30,352,268 (+)RGD
CHM1_1630,554,223 - 30,554,308 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33660 AgrOrtholog
COSMIC MIR877 COSMIC
Ensembl Genes ENSG00000216101 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000401282 ENTREZGENE
GTEx ENSG00000216101 GTEx
HGNC ID HGNC:33660 ENTREZGENE
Human Proteome Map MIR877 Human Proteome Map
miRBase MI0005561 ENTREZGENE
NCBI Gene 100126314 ENTREZGENE
OMIM 611619 OMIM
PharmGKB PA164722984 PharmGKB
RNAcentral URS0000070B1D RNACentral
  URS00005240FD RNACentral
  URS00006A5378 RNACentral