Rhox3g (reproductive homeobox 3G) - Rat Genome Database

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Gene: Rhox3g (reproductive homeobox 3G) Mus musculus
Analyze
No known orthologs.
Symbol: Rhox3g
Name: reproductive homeobox 3G
RGD ID: 2289883
MGI Page MGI
Description: This gene is a member of the reproductive homeobox X-linked family (Rhox), which forms part of the superfamily of Homeobox transcription factors. Rhox family members are thought to contribute to early embryo development as well as female and male gametogenesis because they are expressed during embryogenesis and in reproductive tissues. In the mouse, this family expanded to form gene clusters categorized into alpha, beta and gamma, depending on chromosomal locations. Rhox3 paralogs are in the alpha cluster and are reported to be more highly expressed in testes compared to ovaries. This protein is missing a portion of the N-terminus compared to other Rhox3 paralogs, so its functional capacity is unclear. [provided by RefSeq, Dec 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: reproductive homeobox 3F; reproductive homeobox 3G, pseudogene; Rhox3; Rhox3.7; Rhox3f; Rhox3g-ps
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: This gene was previously named "Rhox3f" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox3.7" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox3g. [26 Apr 2013]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,805,084 - 36,809,792 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,804,971 - 36,810,265 (-)EnsemblGRCm39 Ensembl
GRCm38X37,623,431 - 37,628,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX37,623,318 - 37,628,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X35,037,938 - 35,042,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X33,929,275 - 33,939,688 (-)NCBIMGSCv36mm8
CeleraX24,520,228 - 24,534,012 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15707895   PMID:16465597   PMID:16496311   PMID:16574372   PMID:16916441   PMID:18077458   PMID:18562707   PMID:20430877   PMID:21245380  


Genomics

Variants

.
Variants in Rhox3g
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENSMUST00000119965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
1558721Bw1_mbody weight QTL 1 (mouse)Not determinedX2060678347179225Mouse
12738418Lfibq12_mliver fibrosis QTL 12 (mouse)X2572817443635700Mouse
27226750Femd9_mfemur midshaft diameter 9, 10 week (mouse)X3333746355845360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse

Markers in Region
Dppa3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X37,625,732 - 37,625,831UniSTSGRCm38
MGSCv37X35,040,239 - 35,040,338UniSTSGRCm37
CeleraX24,522,529 - 24,522,628UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic MapXA3.3UniSTS
cM Map148.0UniSTS
cM Map6 UniSTS
Dppa3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F2UniSTS
Cytogenetic MapXA3.3UniSTS
cM Map6 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000119965   ⟹   ENSMUSP00000138947
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX36,804,971 - 36,810,265 (-)Ensembl
GRCm38.p6 EnsemblX37,623,318 - 37,628,612 (-)Ensembl
RefSeq Acc Id: NM_001145406   ⟹   NP_001138878
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X36,805,084 - 36,809,792 (-)NCBI
GRCm38X37,623,431 - 37,628,139 (-)NCBI
MGSCv37X35,037,938 - 35,042,776 (-)RGD
CeleraX24,520,228 - 24,534,012 (-)RGD
cM MapX ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001138878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47476 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000138947
  ENSMUSP00000138947.2
Reference Protein Sequences
RefSeq Acc Id: NP_001138878   ⟸   NM_001145406
- UniProtKB: B9EJQ9 (UniProtKB/TrEMBL),   Q6YI58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138947   ⟸   ENSMUST00000119965
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B9EJQ9-F1-model_v2 AlphaFold B9EJQ9 1-160 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3770313 AgrOrtholog
Ensembl Genes ENSMUSG00000080933 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000119965 ENTREZGENE
  ENSMUST00000119965.3 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report mmu:546294 UniProtKB/TrEMBL
MGD MGI:3770313 ENTREZGENE
NCBI Gene 546294 ENTREZGENE
PANTHER MCG113260-RELATED-RELATED UniProtKB/TrEMBL
  PTHR47465:SF4 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Rhox3g PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt B9EJQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q6YI58 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-30 Rhox3g  reproductive homeobox 3G  Rhox3g-ps  reproductive homeobox 3G, pseudogene  Symbol and/or name change 5135510 APPROVED
2011-07-27 Rhox3g-ps  reproductive homeobox 3G, pseudogene  Rhox3g  reproductive homeobox 3G  Symbol and/or name change 5135510 APPROVED