Derpc (DERPC proline and glycine rich nuclear protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Derpc (DERPC proline and glycine rich nuclear protein) Rattus norvegicus
Analyze
Symbol: Derpc (Ensembl: Chtf8)
Name: DERPC proline and glycine rich nuclear protein (Ensembl:chromosome transmission fidelity factor 8)
RGD ID: 21079726
Description: Predicted to be located in nucleoplasm. Orthologous to human DERPC (DERPC proline and glycine rich nuclear protein); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: decreased expression in renal and prostate cancer protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,692,005 - 51,702,076 (-)NCBIGRCr8
mRatBN7.21934,782,234 - 34,792,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,597,754 - 41,607,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,251,094 - 42,261,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,550,218 - 44,560,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)

References
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15632090   PMID:22673903  


Genomics

Comparative Map Data
Derpc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,692,005 - 51,702,076 (-)NCBIGRCr8
mRatBN7.21934,782,234 - 34,792,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,597,754 - 41,607,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,251,094 - 42,261,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,550,218 - 44,560,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map19q12NCBI
DERPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,118,010 - 69,132,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,118,010 - 69,132,588 (-)EnsemblGRCh38hg38GRCh38
GRCh371669,151,913 - 69,166,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map16q22.1NCBI
T2T-CHM13v2.01674,914,320 - 74,928,895 (-)NCBIT2T-CHM13v2.0
Derpc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,610,495 - 107,620,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,610,522 - 107,620,225 (-)EnsemblGRCm39 Ensembl
GRCm388106,883,863 - 106,893,593 (-)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map8D3NCBI
DERPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,659,322 - 78,661,730 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,570,921 - 84,573,329 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,489,176 - 49,503,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,877,028 - 68,892,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,877,028 - 68,891,513 (-)Ensemblpanpan1.1panPan2
DERPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha580,500,499 - 80,509,750 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,944,026 - 80,953,277 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,943,583 - 80,954,117 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,771,246 - 80,780,496 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,453,796 - 80,463,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,093,717 - 81,102,968 (+)NCBIUU_Cfam_GSD_1.0
Derpc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,304,392 - 40,306,889 (+)NCBIHiC_Itri_2
CHTF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,841,641 - 17,844,366 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,818,184 - 17,844,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DERPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,275,047 - 58,289,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,274,678 - 58,286,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604721,008,343 - 21,022,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Derpc
25 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070822   ⟹   ENSRNOP00000063969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111805   ⟹   ENSRNOP00000096000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,782,201 - 34,786,234 (-)Ensembl
RefSeq Acc Id: NM_001378380   ⟹   NP_001365309
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,692,005 - 51,702,076 (-)NCBI
mRatBN7.21934,782,234 - 34,792,306 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001365309   ⟸   NM_001378380
- UniProtKB: B2RYL1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000096000   ⟸   ENSRNOT00000111805
RefSeq Acc Id: ENSRNOP00000063969   ⟸   ENSRNOT00000070822

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYL1-F1-model_v2 AlphaFold B2RYL1 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:21079726 AgrOrtholog
BioCyc Gene G2FUF-5773 BioCyc
Ensembl Genes ENSRNOG00000047246 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018725 UniProtKB/Swiss-Prot
  ENSRNOG00060012970 UniProtKB/Swiss-Prot
  ENSRNOG00065012304 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000070822 ENTREZGENE
  ENSRNOT00000070822.2 UniProtKB/Swiss-Prot
  ENSRNOT00000111805.1 UniProtKB/Swiss-Prot
  ENSRNOT00055031897 UniProtKB/Swiss-Prot
  ENSRNOT00055031905 UniProtKB/Swiss-Prot
  ENSRNOT00060022076 UniProtKB/Swiss-Prot
  ENSRNOT00060022080 UniProtKB/Swiss-Prot
  ENSRNOT00065020025 UniProtKB/Swiss-Prot
  ENSRNOT00065020032 UniProtKB/Swiss-Prot
NCBI Gene Derpc ENTREZGENE
PANTHER CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) UniProtKB/Swiss-Prot
  DECREASED EXPRESSION IN RENAL AND PROSTATE CANCER PROTEIN UniProtKB/Swiss-Prot
PhenoGen Derpc PhenoGen
RatGTEx ENSRNOG00000047246 RatGTEx
  ENSRNOG00055018725 RatGTEx
  ENSRNOG00060012970 RatGTEx
  ENSRNOG00065012304 RatGTEx
UniProt B2RYL1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-18 Derpc  DERPC proline and glycine rich nuclear protein      Symbol and Name status set to provisional 70820 PROVISIONAL