Rps6kb1 (ribosomal protein S6 kinase B1) - Rat Genome Database

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Gene: Rps6kb1 (ribosomal protein S6 kinase B1) Heterocephalus glaber
Analyze
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
RGD ID: 18936925
Description: ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cell migration (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Atrophy (ortholog); autosomal dominant polycystic kidney disease (ortholog); Burns (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ribosomal protein S6 kinase beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248711,667,291 - 1,702,783 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248711,667,292 - 1,705,550 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral fear response  (IEA,ISO)
cell migration  (ISO)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (IEA)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to nutrient  (IEA)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to type II interferon  (IEA)
G1/S transition of mitotic cell cycle  (IEA)
germ cell development  (IEA,ISO)
long-chain fatty acid import into cell  (IEA)
long-term memory  (ISO)
modulation of chemical synaptic transmission  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of TORC1 signaling  (IEA)
positive regulation of translation  (IEA)
positive regulation of translational initiation  (IEA)
protein phosphorylation  (ISO)
regulation of glucose import  (ISO)
response to amino acid  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to ethanol  (ISO)
response to glucagon  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to insulin  (ISO)
response to L-leucine  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (IEA)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
skeletal muscle atrophy  (ISO)
skeletal muscle contraction  (ISO)
TOR signaling  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rps6kb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248711,667,291 - 1,702,783 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248711,667,292 - 1,705,550 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RPS6KB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,893,046 - 59,950,574 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,970,482 - 58,027,935 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36Build 36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
T2T-CHM13v2.01760,761,869 - 60,819,318 (+)NCBIT2T-CHM13v2.0
Rps6kb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,389,695 - 86,435,711 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,389,697 - 86,435,631 (-)EnsemblGRCm39 Ensembl
GRCm381186,498,869 - 86,544,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,498,871 - 86,544,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,312,511 - 86,358,309 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,330,178 - 86,360,969 (-)NCBIMGSCv36mm8
Celera1196,115,093 - 96,160,675 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
Rps6kb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,817,794 - 71,865,211 (-)NCBIGRCr8
mRatBN7.21071,323,777 - 71,367,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,323,777 - 71,367,908 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1075,946,721 - 75,987,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,451,529 - 75,492,547 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,916,142 - 70,957,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Celera1070,248,523 - 70,289,589 (-)NCBICelera
Cytogenetic Map10q26NCBI
Rps6kb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554513,181,085 - 3,225,610 (-)NCBIChiLan1.0ChiLan1.0
RPS6KB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21976,055,147 - 76,111,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11780,866,830 - 80,922,483 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11758,798,930 - 58,856,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)Ensemblpanpan1.1panPan2
RPS6KB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,387,084 - 34,590,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,387,091 - 34,425,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,618,891 - 33,820,779 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,197,993 - 35,401,137 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,198,048 - 35,253,131 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,981,681 - 34,184,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,266,735 - 34,469,058 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,353,112 - 34,555,827 (+)NCBIUU_Cfam_GSD_1.0
Rps6kb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,582,174 - 33,634,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,441,055 - 3,492,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,441,046 - 3,492,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,111,653 - 36,160,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11633,498,098 - 33,556,553 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1633,497,392 - 33,556,453 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660774,283,812 - 4,342,844 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000012181   ⟹   ENSHGLP00000012048
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248711,667,291 - 1,702,783 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000012182   ⟹   ENSHGLP00000012049
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248711,667,389 - 1,692,861 (+)Ensembl
RefSeq Acc Id: XM_004870371   ⟹   XP_004870428
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248711,667,297 - 1,705,550 (+)NCBI
RefSeq Acc Id: XM_004870373   ⟹   XP_004870430
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248711,668,030 - 1,705,550 (+)NCBI
RefSeq Acc Id: XM_004870374   ⟹   XP_004870431
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248711,667,292 - 1,702,170 (+)NCBI
RefSeq Acc Id: XM_013067698   ⟹   XP_012923152
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248711,667,292 - 1,702,143 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870428 (Get FASTA)   NCBI Sequence Viewer  
  XP_004870430 (Get FASTA)   NCBI Sequence Viewer  
  XP_004870431 (Get FASTA)   NCBI Sequence Viewer  
  XP_012923152 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012048
  ENSHGLP00100014640
GenBank Protein JAN98643 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004870431   ⟸   XM_004870374
- Peptide Label: isoform X3
- UniProtKB: G5BD47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923152   ⟸   XM_013067698
- Peptide Label: isoform X4
- UniProtKB: G5BD47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004870428   ⟸   XM_004870371
- Peptide Label: isoform X1
- UniProtKB: G5C898 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004870430   ⟸   XM_004870373
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000012048   ⟸   ENSHGLT00000012181
RefSeq Acc Id: ENSHGLP00000012049   ⟸   ENSHGLT00000012182


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008626 Ensembl, ENTREZGENE
  ENSHGLG00100010833 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000012181 ENTREZGENE
  ENSHGLT00100014801 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report hgl:101724077 UniProtKB/TrEMBL
NCBI Gene Rps6kb1 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE BETA-1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_1 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt G5BD47 ENTREZGENE, UniProtKB/TrEMBL
  G5C898 ENTREZGENE, UniProtKB/TrEMBL