Ttc5 (tetratricopeptide repeat domain 5) - Rat Genome Database

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Gene: Ttc5 (tetratricopeptide repeat domain 5) Heterocephalus glaber
Analyze
Symbol: Ttc5
Name: tetratricopeptide repeat domain 5
RGD ID: 18936897
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); ribosome binding (ortholog); INVOLVED IN cellular response to starvation (ortholog); DNA damage response (ortholog); positive regulation of mRNA catabolic process (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH genetic disease (ortholog); NEURODEVELOPMENTAL DISORDER WITH CEREBRAL ATROPHY AND VARIABLE FACIAL DYSMORPHISM (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: tetratricopeptide repeat protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,863,028 - 4,900,363 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,863,610 - 4,923,164 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:26763976  


Genomics

Comparative Map Data
Ttc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,863,028 - 4,900,363 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,863,610 - 4,923,164 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TTC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,286,227 - 20,305,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,256,558 - 20,305,960 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,754,386 - 20,774,110 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,827,144 - 19,843,976 (-)NCBINCBI36Build 36hg18NCBI36
Build 341419,827,143 - 19,843,976NCBI
Celera14618,437 - 635,301 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14879,432 - 896,309 (-)NCBIHuRef
CHM1_11420,758,235 - 20,775,107 (-)NCBICHM1_1
T2T-CHM13v2.01414,483,002 - 14,502,708 (-)NCBIT2T-CHM13v2.0
Ttc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,002,866 - 51,022,977 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,002,872 - 51,022,976 (-)EnsemblGRCm39 Ensembl
GRCm381450,765,409 - 50,785,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,765,415 - 50,785,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,385,090 - 51,405,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,697,406 - 49,707,446 (-)NCBIMGSCv36mm8
Celera1447,053,176 - 47,073,234 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.24NCBI
Ttc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,466,613 - 26,484,269 (-)NCBIGRCr8
mRatBN7.21523,993,046 - 24,010,710 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,993,048 - 24,010,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,764,272 - 26,781,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,722,902 - 27,740,465 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,972,796 - 25,990,392 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,698,375 - 27,715,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,698,362 - 27,716,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,530,800 - 31,548,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,749,259 - 26,766,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,764,960 - 26,782,548 (-)NCBI
Celera1524,312,000 - 24,330,147 (-)NCBICelera
Cytogenetic Map15p14NCBI
Ttc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,074,170 - 1,105,357 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,073,697 - 1,105,055 (-)NCBIChiLan1.0ChiLan1.0
TTC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,795,330 - 21,815,184 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,011,312 - 21,031,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,163,280 - 1,180,212 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,214,337 - 19,233,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,216,993 - 19,233,797 (-)Ensemblpanpan1.1panPan2
TTC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,653,008 - 17,670,231 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,638,462 - 17,670,575 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,137,305 - 18,155,363 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01517,910,664 - 17,929,053 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1517,910,691 - 17,929,008 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,594,498 - 17,612,265 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,648,692 - 17,666,694 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,777,371 - 17,795,817 (-)NCBIUU_Cfam_GSD_1.0
Ttc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,515,241 - 77,539,652 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936877501,743 - 520,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936877504,406 - 520,295 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,578,294 - 78,600,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,578,247 - 78,600,794 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,606,604 - 83,626,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,809,004 - 20,825,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,808,945 - 20,826,111 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,595,832 - 25,612,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026834   ⟹   ENSHGLP00000026598
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248254,863,028 - 4,900,363 (+)Ensembl
RefSeq Acc Id: NM_001310261   ⟹   NP_001297190
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248254,863,656 - 4,900,298 (+)NCBI
RefSeq Acc Id: XM_021244497   ⟹   XP_021100156
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248254,863,611 - 4,903,360 (+)NCBI
RefSeq Acc Id: XR_002389378
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248254,863,610 - 4,923,164 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001297190 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ09076 (Get FASTA)   NCBI Sequence Viewer  
  EHB04614 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026598
Reference Protein Sequences
RefSeq Acc Id: XP_021100156   ⟸   XM_021244497
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001297190   ⟸   NM_001310261
- UniProtKB: G5B5Q3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026598   ⟸   ENSHGLT00000026834


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018917 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026834 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.40.50.550 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC5_OB UniProtKB/TrEMBL
  TTC5_OB_sf UniProtKB/TrEMBL
KEGG Report hgl:101713791 UniProtKB/TrEMBL
NCBI Gene Ttc5 ENTREZGENE
PANTHER TETRATRICOPEPTIDE REPEAT PROTEIN 5 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 5 UniProtKB/TrEMBL
Pfam TTC5_OB UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt G5B5Q3 ENTREZGENE, UniProtKB/TrEMBL