Epha1 (EPH receptor A1) - Rat Genome Database

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Gene: Epha1 (EPH receptor A1) Heterocephalus glaber
Analyze
Symbol: Epha1
Name: EPH receptor A1
RGD ID: 18936600
Description: ENCODES a protein that exhibits fibronectin binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); negative regulation of cell migration (ortholog); positive regulation of angiogenesis (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Alzheimer's disease (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendrite (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-A receptor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,364,848 - 11,380,725 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,364,685 - 11,380,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IEA)
membrane  (IEA)
plasma membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Epha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,364,848 - 11,380,725 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,364,685 - 11,380,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EPHA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,391,129 - 143,408,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,390,289 - 143,408,856 (-)EnsemblGRCh38hg38GRCh38
GRCh377143,088,222 - 143,105,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,798,327 - 142,816,107 (-)NCBINCBI36Build 36hg18NCBI36
Build 347142,605,042 - 142,622,822NCBI
Celera7137,925,469 - 137,943,251 (-)NCBICelera
Cytogenetic Map7q34-q35NCBI
HuRef7137,425,521 - 137,443,246 (-)NCBIHuRef
CHM1_17143,025,132 - 143,041,700 (-)NCBICHM1_1
T2T-CHM13v2.07144,746,556 - 144,764,287 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,490,337 - 142,508,118 (-)NCBI
Epha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,335,421 - 42,350,249 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,335,421 - 42,350,202 (-)EnsemblGRCm39 Ensembl
GRCm38642,358,487 - 42,373,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,358,487 - 42,373,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37642,308,486 - 42,323,267 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,288,094 - 42,302,875 (-)NCBIMGSCv36mm8
Celera642,303,129 - 42,317,914 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.65NCBI
Epha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,213,022 - 72,227,543 (-)NCBIGRCr8
mRatBN7.2471,246,409 - 71,260,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,246,409 - 71,260,846 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,166,330 - 76,180,773 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,079,589 - 72,094,032 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,499,006 - 70,513,444 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,749,100 - 71,763,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,749,242 - 71,763,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,553,640 - 136,568,077 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,127,872 - 70,142,309 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1470,404,001 - 70,418,438 (-)NCBI
Celera466,176,888 - 66,191,325 (-)NCBICelera
Cytogenetic Map4q24NCBI
Epha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494255,162 - 268,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955494256,008 - 268,777 (+)NCBIChiLan1.0ChiLan1.0
EPHA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,243,561 - 180,261,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,253,818 - 32,271,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,385,894 - 135,403,632 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,875,028 - 147,892,064 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,875,363 - 147,892,745 (-)Ensemblpanpan1.1panPan2
EPHA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,287,757 - 6,304,082 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,287,910 - 6,304,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,276,373 - 7,292,601 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,141,123 - 6,157,305 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,141,091 - 6,157,301 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,089,005 - 6,105,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,940,565 - 5,956,781 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,015,778 - 6,032,015 (+)NCBIUU_Cfam_GSD_1.0
Epha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,055,439 - 12,069,849 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527830,112 - 848,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527833,578 - 847,824 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,843,299 - 6,860,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,843,305 - 6,860,976 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,081,296 - 7,098,902 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,276,941 - 112,294,505 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,277,427 - 112,294,424 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,023,000 - 9,040,431 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000010709   ⟹   ENSHGLP00000010590
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480011,364,848 - 11,380,725 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000010710   ⟹   ENSHGLP00000010591
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480011,364,905 - 11,380,423 (+)Ensembl
RefSeq Acc Id: XM_004860490   ⟹   XP_004860547
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,364,905 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240922   ⟹   XP_021096581
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,365,200 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240923   ⟹   XP_021096582
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,364,841 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240924   ⟹   XP_021096583
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,365,200 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240925   ⟹   XP_021096584
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,364,685 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240926   ⟹   XP_021096585
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,365,686 - 11,380,725 (+)NCBI
RefSeq Acc Id: XM_021240927   ⟹   XP_021096586
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480011,365,200 - 11,378,713 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021096584   ⟸   XM_021240925
- Peptide Label: isoform X5
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096582   ⟸   XM_021240923
- Peptide Label: isoform X2
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004860547   ⟸   XM_004860490
- Peptide Label: isoform X4
- UniProtKB: A0A0P6JUT9 (UniProtKB/TrEMBL),   G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096581   ⟸   XM_021240922
- Peptide Label: isoform X1
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096583   ⟸   XM_021240924
- Peptide Label: isoform X3
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096586   ⟸   XM_021240927
- Peptide Label: isoform X6
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096585   ⟸   XM_021240926
- Peptide Label: isoform X5
- UniProtKB: G5C2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000010591   ⟸   ENSHGLT00000010710
RefSeq Acc Id: ENSHGLP00000010590   ⟸   ENSHGLT00000010709


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007593 Ensembl, ENTREZGENE
  ENSHGLG00100018795 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000010709 ENTREZGENE
  ENSHGLT00100025890 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphA1_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
KEGG Report hgl:101710388 UniProtKB/TrEMBL
NCBI Gene Epha1 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 3 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0P6JUT9 ENTREZGENE, UniProtKB/TrEMBL
  G5C2M3 ENTREZGENE, UniProtKB/TrEMBL