Necab2 (N-terminal EF-hand calcium binding protein 2) - Rat Genome Database

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Gene: Necab2 (N-terminal EF-hand calcium binding protein 2) Heterocephalus glaber
Analyze
Symbol: Necab2
Name: N-terminal EF-hand calcium binding protein 2
RGD ID: 18936588
Description: ENCODES a protein that exhibits A2A adenosine receptor binding (ortholog); identical protein binding (ortholog); type 5 metabotropic glutamate receptor binding (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor internalization (ortholog); positive regulation of adenosine receptor signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH genetic disease (ortholog); Malonic Aciduria (ortholog); persistent fetal circulation syndrome (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-terminal EF-hand calcium-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,552,719 - 3,577,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,552,719 - 3,574,124 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Necab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,552,719 - 3,577,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,552,719 - 3,574,124 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NECAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381683,965,177 - 84,002,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1683,968,244 - 84,002,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371684,001,849 - 84,036,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,559,738 - 82,593,880 (+)NCBINCBI36Build 36hg18NCBI36
Build 341682,559,737 - 82,593,878NCBI
Celera1668,304,639 - 68,338,784 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1669,754,045 - 69,790,327 (+)NCBIHuRef
CHM1_11685,413,645 - 85,447,739 (+)NCBICHM1_1
T2T-CHM13v2.01690,031,233 - 90,068,832 (+)NCBIT2T-CHM13v2.0
Necab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,173,431 - 120,199,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,173,458 - 120,199,379 (+)EnsemblGRCm39 Ensembl
GRCm388119,446,719 - 119,472,640 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,446,719 - 119,472,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv378121,970,619 - 121,996,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,332,696 - 122,358,612 (+)NCBIMGSCv36mm8
Celera8123,664,580 - 123,689,964 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.73NCBI
Necab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,409,627 - 64,436,371 (+)NCBIGRCr8
mRatBN7.21947,501,351 - 47,527,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,501,302 - 47,527,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,295,727 - 54,322,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01954,976,533 - 55,002,936 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,189,946 - 57,216,301 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,086,325 - 52,112,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,086,325 - 52,112,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,834,865 - 62,861,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,691,466 - 49,718,718 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,696,347 - 49,723,599 (+)NCBI
Celera1946,743,032 - 46,786,775 (+)NCBICelera
Cytogenetic Map19q12NCBI
Necab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564258,222 - 277,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955564257,781 - 279,937 (-)NCBIChiLan1.0ChiLan1.0
NECAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,716,998 - 93,750,851 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,633,754 - 99,668,065 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,636,198 - 64,670,019 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11683,979,108 - 84,013,436 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1683,983,626 - 84,013,436 (+)Ensemblpanpan1.1panPan2
NECAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,313,699 - 68,342,253 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,314,000 - 68,378,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,327,774 - 68,357,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,612,120 - 68,641,500 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,612,421 - 68,641,500 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,559,839 - 68,589,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,396,250 - 68,425,583 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,812,005 - 68,841,393 (-)NCBIUU_Cfam_GSD_1.0
Necab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934928,025,477 - 28,046,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,779,374 - 3,799,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,779,024 - 3,802,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NECAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.164,598,752 - 4,641,450 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NECAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,380,328 - 69,413,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660476,360,688 - 6,394,401 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000019378   ⟹   ENSHGLP00000019187
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247463,552,719 - 3,577,433 (-)Ensembl
RefSeq Acc Id: XM_021256652   ⟹   XP_021112311
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,572,144 (-)NCBI
RefSeq Acc Id: XM_021256653   ⟹   XP_021112312
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,574,121 (-)NCBI
RefSeq Acc Id: XM_021256654   ⟹   XP_021112313
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,571,576 (-)NCBI
RefSeq Acc Id: XM_021256655   ⟹   XP_021112314
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,572,141 (-)NCBI
RefSeq Acc Id: XM_021256656   ⟹   XP_021112315
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,571,566 (-)NCBI
RefSeq Acc Id: XM_021256657   ⟹   XP_021112316
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,554,798 - 3,572,145 (-)NCBI
RefSeq Acc Id: XM_021256658   ⟹   XP_021112317
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,574,115 (-)NCBI
RefSeq Acc Id: XM_021256659   ⟹   XP_021112318
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,574,115 (-)NCBI
RefSeq Acc Id: XM_021256661   ⟹   XP_021112320
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247463,552,719 - 3,574,124 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021112320   ⟸   XM_021256661
- Peptide Label: isoform X7
RefSeq Acc Id: XP_021112312   ⟸   XM_021256653
- Peptide Label: isoform X2
- UniProtKB: G5BFX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112318   ⟸   XM_021256659
- Peptide Label: isoform X7
RefSeq Acc Id: XP_021112317   ⟸   XM_021256658
- Peptide Label: isoform X7
RefSeq Acc Id: XP_021112311   ⟸   XM_021256652
- Peptide Label: isoform X1
- UniProtKB: G5BFX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112314   ⟸   XM_021256655
- Peptide Label: isoform X4
- UniProtKB: G5BFX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112313   ⟸   XM_021256654
- Peptide Label: isoform X3
- UniProtKB: G5BFX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112315   ⟸   XM_021256656
- Peptide Label: isoform X5
- UniProtKB: G5BFX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112316   ⟸   XM_021256657
- Peptide Label: isoform X6
RefSeq Acc Id: ENSHGLP00000019187   ⟸   ENSHGLT00000019378


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013768 Ensembl
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro ABM_dom UniProtKB/TrEMBL
  Dimeric_a/b-barrel UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  NECAB1/2/3 UniProtKB/TrEMBL
NCBI Gene Necab2 ENTREZGENE
PANTHER EF-HAND DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 2 UniProtKB/TrEMBL
Pfam ABM UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PROSITE ABM UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP Dimeric alpha+beta barrel UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
UniProt G5BFX8 ENTREZGENE, UniProtKB/TrEMBL