Dennd6b (DENN domain containing 6B) - Rat Genome Database

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Gene: Dennd6b (DENN domain containing 6B) Heterocephalus glaber
Analyze
Symbol: Dennd6b
Name: DENN domain containing 6B
RGD ID: 18936258
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); chromosome 22q13 duplication syndrome (ortholog); congenital disorder of glycosylation Ig (ortholog); FOUND IN recycling endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein DENND6B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752459,087 - 473,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752459,694 - 472,606 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Dennd6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752459,087 - 473,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752459,694 - 472,606 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DENND6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,309,030 - 50,327,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,309,030 - 50,327,012 (-)EnsemblGRCh38hg38GRCh38
GRCh372250,747,459 - 50,765,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,092,964 - 49,100,010 (-)NCBINCBI36Build 36hg18NCBI36
Celera2234,626,857 - 34,634,095 (-)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,648,422 - 33,655,557 (-)NCBIHuRef
CHM1_12250,709,132 - 50,724,188 (-)NCBICHM1_1
T2T-CHM13v2.02250,816,794 - 50,834,878 (-)NCBIT2T-CHM13v2.0
Dennd6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,066,416 - 89,080,793 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,066,416 - 89,080,699 (-)EnsemblGRCm39 Ensembl
GRCm381589,182,213 - 89,198,427 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,182,213 - 89,196,496 (-)EnsemblGRCm38mm10GRCm38
MGSCv371589,012,643 - 89,026,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,012,578 - 89,024,258 (-)NCBIMGSCv36mm8
Celera1591,311,411 - 91,325,670 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.7NCBI
Dennd6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,139,159 - 122,154,720 (-)NCBIGRCr8
mRatBN7.27120,261,679 - 120,273,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,261,679 - 120,273,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,012,826 - 122,024,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,238,988 - 124,250,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,201,862 - 124,213,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,162,728 - 130,178,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,164,675 - 130,176,696 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,850,713 - 129,864,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,486,531 - 127,498,345 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,521,055 - 127,532,596 (-)NCBI
Celera7116,735,546 - 116,747,360 (-)NCBICelera
Cytogenetic Map7q34NCBI
Dennd6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,324,087 - 33,336,518 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,324,081 - 33,336,518 (-)NCBIChiLan1.0ChiLan1.0
DENND6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,215,602 - 60,233,210 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12262,901,777 - 62,919,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,541,364 - 30,556,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,539,957 - 49,547,463 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,539,957 - 49,547,464 (-)Ensemblpanpan1.1panPan2
DENND6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,939,946 - 16,948,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,939,093 - 16,948,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,917,015 - 16,928,053 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,665,772 - 17,676,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,664,878 - 17,676,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,389,904 - 17,400,935 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,712,993 - 17,724,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,845,365 - 17,856,403 (+)NCBIUU_Cfam_GSD_1.0
Dennd6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945498,126 - 509,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629498,127 - 509,751 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936629498,120 - 509,758 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5376,551 - 389,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15376,556 - 389,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DENND6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,801,068 - 32,815,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,534,998 - 92,553,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000009700   ⟹   ENSHGLP00000009593
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624752459,087 - 473,277 (+)Ensembl
RefSeq Acc Id: XM_004845318   ⟹   XP_004845375
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,695 - 470,616 (+)NCBI
RefSeq Acc Id: XM_004845320   ⟹   XP_004845377
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,698 - 470,616 (+)NCBI
RefSeq Acc Id: XM_004845321   ⟹   XP_004845378
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,694 - 470,616 (+)NCBI
RefSeq Acc Id: XM_004845322   ⟹   XP_004845379
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,698 - 470,616 (+)NCBI
RefSeq Acc Id: XM_004845324   ⟹   XP_004845381
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,702 - 470,616 (+)NCBI
RefSeq Acc Id: XM_004845325   ⟹   XP_004845382
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,890 - 470,616 (+)NCBI
RefSeq Acc Id: XM_021258727   ⟹   XP_021114386
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,694 - 472,546 (+)NCBI
RefSeq Acc Id: XM_021258728   ⟹   XP_021114387
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,694 - 472,606 (+)NCBI
RefSeq Acc Id: XM_021258729   ⟹   XP_021114388
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,694 - 470,616 (+)NCBI
RefSeq Acc Id: XM_021258731   ⟹   XP_021114390
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,695 - 470,616 (+)NCBI
RefSeq Acc Id: XM_021258732   ⟹   XP_021114391
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,699 - 470,616 (+)NCBI
RefSeq Acc Id: XM_021258733   ⟹   XP_021114392
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,890 - 470,616 (+)NCBI
RefSeq Acc Id: XM_021258734   ⟹   XP_021114393
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624752459,890 - 470,616 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021114387   ⟸   XM_021258728
- Peptide Label: isoform X1
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114386   ⟸   XM_021258727
- Peptide Label: isoform X1
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114388   ⟸   XM_021258729
- Peptide Label: isoform X2
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845378   ⟸   XM_004845321
- Peptide Label: isoform X4
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845375   ⟸   XM_004845318
- Peptide Label: isoform X1
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114390   ⟸   XM_021258731
- Peptide Label: isoform X6
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845379   ⟸   XM_004845322
- Peptide Label: isoform X5
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845377   ⟸   XM_004845320
- Peptide Label: isoform X3
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114391   ⟸   XM_021258732
- Peptide Label: isoform X8
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845381   ⟸   XM_004845324
- Peptide Label: isoform X7
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114392   ⟸   XM_021258733
- Peptide Label: isoform X9
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114393   ⟸   XM_021258734
- Peptide Label: isoform X10
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845382   ⟸   XM_004845325
- Peptide Label: isoform X11
- UniProtKB: G5B2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000009593   ⟸   ENSHGLT00000009700


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006881 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009700 ENTREZGENE
InterPro cDENN_dom UniProtKB/TrEMBL
  DENND6 UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
NCBI Gene Dennd6b ENTREZGENE
PANTHER PROTEIN DENND6B UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam DENN UniProtKB/TrEMBL
PROSITE DENN UniProtKB/TrEMBL
UniProt G5B2H7 ENTREZGENE, UniProtKB/TrEMBL