Plcb4 (phospholipase C beta 4) - Rat Genome Database

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Gene: Plcb4 (phospholipase C beta 4) Heterocephalus glaber
Analyze
Symbol: Plcb4
Name: phospholipase C beta 4
RGD ID: 18935985
Description: ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); negative regulation of potassium ion transport (ortholog); phospholipase C-activating endothelin receptor signaling pathway (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH Alagille syndrome (ortholog); ALAGILLE SYNDROME 1 (ortholog); Auriculocondylar Syndrome (ortholog); FOUND IN dendrite (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474110,277,805 - 10,430,327 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plcb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474110,277,805 - 10,430,327 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PLCB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38209,068,678 - 9,480,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl209,067,825 - 9,504,593 (+)EnsemblGRCh38hg38GRCh38
GRCh37209,049,325 - 9,461,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36209,024,932 - 9,409,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 34209,024,931 - 9,409,460NCBI
Celera209,119,817 - 9,531,474 (+)NCBICelera
Cytogenetic Map20p12.3-p12.2NCBI
HuRef209,001,542 - 9,413,398 (+)NCBIHuRef
CHM1_1209,050,899 - 9,462,613 (+)NCBICHM1_1
T2T-CHM13v2.0209,111,633 - 9,523,716 (+)NCBIT2T-CHM13v2.0
Plcb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392135,500,523 - 135,856,522 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2135,500,931 - 135,856,513 (+)EnsemblGRCm39 Ensembl
GRCm382135,658,603 - 136,014,602 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2135,659,011 - 136,014,593 (+)EnsemblGRCm38mm10GRCm38
MGSCv372135,567,566 - 135,838,804 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362135,433,271 - 135,704,509 (+)NCBIMGSCv36mm8
Celera2136,939,191 - 137,211,347 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map266.64NCBI
Plcb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83143,405,721 - 143,775,129 (+)NCBIGRCr8
mRatBN7.23122,952,965 - 123,322,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3122,953,196 - 123,322,392 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3126,861,256 - 127,230,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03135,448,283 - 135,807,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03133,116,870 - 133,485,687 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03128,601,163 - 128,971,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3128,756,799 - 128,971,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03135,089,551 - 135,459,248 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43123,706,313 - 124,077,381 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13123,611,885 - 123,982,941 (+)NCBI
Celera3121,694,557 - 122,062,160 (+)NCBICelera
Cytogenetic Map3q36NCBI
Plcb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541519,310,917 - 19,463,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541519,108,120 - 19,462,084 (+)NCBIChiLan1.0ChiLan1.0
PLCB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2219,967,849 - 10,403,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1209,964,676 - 10,400,261 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0209,042,127 - 9,454,207 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1208,846,152 - 9,456,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl209,192,061 - 9,456,443 (+)Ensemblpanpan1.1panPan2
PLCB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12412,750,631 - 13,169,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2412,752,083 - 13,169,745 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2412,575,552 - 12,993,940 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02413,157,425 - 13,576,878 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2413,157,425 - 13,576,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12412,769,385 - 13,187,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02412,868,981 - 13,288,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02413,206,767 - 13,626,337 (-)NCBIUU_Cfam_GSD_1.0
Plcb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640161,560,396 - 161,921,708 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364859,991,299 - 10,353,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364859,991,731 - 10,353,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1717,916,110 - 18,402,532 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11717,915,984 - 18,402,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21720,428,956 - 20,770,454 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,650,604 - 29,059,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,650,421 - 28,915,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607115,510,020 - 15,919,543 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021255048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01019100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01003517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000025810   ⟹   ENSHGLP00000025584
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474110,277,805 - 10,430,307 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000025811   ⟹   ENSHGLP00000025585
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474110,362,767 - 10,430,327 (+)Ensembl
RefSeq Acc Id: XM_021255048   ⟹   XP_021110707
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255049   ⟹   XP_021110708
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255050   ⟹   XP_021110709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255051   ⟹   XP_021110710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255053   ⟹   XP_021110712
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,047,899 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255054   ⟹   XP_021110713
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,048,216 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255055   ⟹   XP_021110714
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,048,070 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255056   ⟹   XP_021110715
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,048,213 - 10,435,088 (+)NCBI
RefSeq Acc Id: XM_021255057   ⟹   XP_021110716
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474110,276,278 - 10,435,088 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021110707   ⟸   XM_021255048
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110710   ⟸   XM_021255051
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110708   ⟸   XM_021255049
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110712   ⟸   XM_021255053
- Peptide Label: isoform X5
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110709   ⟸   XM_021255050
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110714   ⟸   XM_021255055
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110715   ⟸   XM_021255056
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110713   ⟸   XM_021255054
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110716   ⟸   XM_021255057
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J799 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000025585   ⟸   ENSHGLT00000025811
RefSeq Acc Id: ENSHGLP00000025584   ⟸   ENSHGLT00000025810


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018217 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100016298 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000025810 ENTREZGENE
  ENSHGLT00000078436 UniProtKB/TrEMBL
  ENSHGLT00100056229 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1230.10 UniProtKB/TrEMBL
  2.30.29.240 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-beta UniProtKB/TrEMBL
  PLC-beta_C_sf UniProtKB/TrEMBL
  PLC-beta_CS UniProtKB/TrEMBL
  PLC-beta_PH UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
NCBI Gene Plcb4 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 UniProtKB/TrEMBL
  PTHR10336 UniProtKB/TrEMBL
Pfam DUF1154 UniProtKB/TrEMBL
  EF-hand_like UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PH_14 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
PIRSF PLC-beta UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
PROSITE PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
UniProt A0A0P6J799 ENTREZGENE, UniProtKB/TrEMBL