Mast4 (microtubule associated serine/threonine kinase family member 4) - Rat Genome Database

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Gene: Mast4 (microtubule associated serine/threonine kinase family member 4) Heterocephalus glaber
Analyze
Symbol: Mast4
Name: microtubule associated serine/threonine kinase family member 4
RGD ID: 18934677
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); magnesium ion binding (inferred); INVOLVED IN cytoskeleton organization (inferred); intracellular signal transduction (inferred); ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: microtubule-associated serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248152,539,785 - 3,139,696 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248152,539,867 - 3,139,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mast4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248152,539,785 - 3,139,696 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248152,539,867 - 3,139,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAST4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38566,596,393 - 67,169,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl566,596,380 - 67,169,593 (+)EnsemblGRCh38hg38GRCh38
GRCh37565,892,221 - 66,465,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36565,927,932 - 66,498,848 (+)NCBINCBI36Build 36hg18NCBI36
Celera562,890,649 - 63,463,832 (+)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef562,849,136 - 63,424,533 (+)NCBIHuRef
CHM1_1565,892,076 - 66,465,814 (+)NCBICHM1_1
T2T-CHM13v2.0567,418,473 - 67,991,744 (+)NCBIT2T-CHM13v2.0
Mast4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913102,868,996 - 103,471,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13102,868,994 - 103,471,005 (-)EnsemblGRCm39 Ensembl
GRCm3813102,732,486 - 103,335,099 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13102,732,486 - 103,334,497 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713103,522,568 - 104,124,572 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613103,852,872 - 104,455,486 (-)NCBIMGSCv36mm8
Celera13106,322,570 - 106,925,726 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1354.94NCBI
Mast4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8235,627,190 - 36,219,090 (-)NCBIGRCr8
mRatBN7.2233,893,241 - 34,483,682 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl233,894,436 - 34,483,723 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0232,857,576 - 33,451,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl232,444,565 - 32,518,643 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl232,859,856 - 33,025,271 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0251,996,218 - 52,352,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0251,582,787 - 51,662,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4233,648,515 - 34,242,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera229,878,176 - 30,467,200 (-)NCBICelera
Cytogenetic Map2q13NCBI
Mast4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554461,974,363 - 2,514,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,974,363 - 2,514,161 (-)NCBIChiLan1.0ChiLan1.0
MAST4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2446,747,104 - 47,329,678 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1544,900,733 - 45,483,305 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0546,827,595 - 47,414,708 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1548,394,433 - 48,829,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl548,396,973 - 48,970,233 (-)Ensemblpanpan1.1panPan2
MAST4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1252,241,621 - 52,633,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl252,185,407 - 52,633,243 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha249,060,227 - 49,597,951 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0252,591,450 - 53,135,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl252,591,158 - 53,133,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1249,656,736 - 50,200,538 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0250,444,848 - 50,983,150 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0251,332,587 - 51,871,159 (+)NCBIUU_Cfam_GSD_1.0
Mast4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213193,209,037 - 193,760,397 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364802,145,495 - 2,696,582 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364802,145,515 - 2,307,842 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAST4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1645,383,207 - 45,561,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11644,972,519 - 45,562,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21649,238,295 - 49,280,859 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAST4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1462,774,274 - 63,349,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl463,181,153 - 63,349,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604911,429,491 - 12,009,589 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004862844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004862845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004862846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004862847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01078073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01078088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01002891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000007289   ⟹   ENSHGLP00000007204
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248152,539,785 - 2,771,392 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007290   ⟹   ENSHGLP00000007205
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248152,539,785 - 2,731,191 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007291   ⟹   ENSHGLP00000007206
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248152,542,321 - 3,139,696 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007292   ⟹   ENSHGLP00000007207
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248152,542,321 - 2,774,885 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007293   ⟹   ENSHGLP00000007208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248152,609,757 - 2,919,884 (-)Ensembl
RefSeq Acc Id: XM_004862844   ⟹   XP_004862901
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 3,139,943 (-)NCBI
RefSeq Acc Id: XM_004862845   ⟹   XP_004862902
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 3,139,942 (-)NCBI
RefSeq Acc Id: XM_004862846   ⟹   XP_004862903
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,775,098 (-)NCBI
RefSeq Acc Id: XM_004862847   ⟹   XP_004862904
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,730,674 (-)NCBI
RefSeq Acc Id: XM_013078953   ⟹   XP_012934407
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,730,673 (-)NCBI
RefSeq Acc Id: XM_013078954   ⟹   XP_012934408
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,730,314 (-)NCBI
RefSeq Acc Id: XM_021242944   ⟹   XP_021098603
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 3,139,942 (-)NCBI
RefSeq Acc Id: XM_021242945   ⟹   XP_021098604
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 3,139,942 (-)NCBI
RefSeq Acc Id: XM_021242946   ⟹   XP_021098605
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,919,857 (-)NCBI
RefSeq Acc Id: XM_021242947   ⟹   XP_021098606
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248152,539,867 - 2,919,867 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004862901   ⟸   XM_004862844
- Peptide Label: isoform X1
- UniProtKB: G5C369 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862902   ⟸   XM_004862845
- Peptide Label: isoform X4
- UniProtKB: G5C369 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098604   ⟸   XM_021242945
- Peptide Label: isoform X3
- UniProtKB: G5C369 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098603   ⟸   XM_021242944
- Peptide Label: isoform X2
- UniProtKB: G5C369 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098606   ⟸   XM_021242947
- Peptide Label: isoform X9
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098605   ⟸   XM_021242946
- Peptide Label: isoform X5
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862903   ⟸   XM_004862846
- Peptide Label: isoform X6
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862904   ⟸   XM_004862847
- Peptide Label: isoform X7
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012934407   ⟸   XM_013078953
- Peptide Label: isoform X8
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012934408   ⟸   XM_013078954
- Peptide Label: isoform X10
- UniProtKB: A0A0N8EU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007205   ⟸   ENSHGLT00000007290
RefSeq Acc Id: ENSHGLP00000007208   ⟸   ENSHGLT00000007293
RefSeq Acc Id: ENSHGLP00000007206   ⟸   ENSHGLT00000007291
RefSeq Acc Id: ENSHGLP00000007207   ⟸   ENSHGLT00000007292
RefSeq Acc Id: ENSHGLP00000007204   ⟸   ENSHGLT00000007289


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005251 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007290 ENTREZGENE
  ENSHGLT00000007291 ENTREZGENE
  ENSHGLT00000007292 ENTREZGENE
Gene3D-CATH 1.20.1480.20 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MA_Ser/Thr_Kinase_dom UniProtKB/TrEMBL
  MAST UniProtKB/TrEMBL
  MAST_pre-PK_dom_sf UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mast4 ENTREZGENE
PANTHER MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 4 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam DUF1908 UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF140482 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0N8EU09 ENTREZGENE, UniProtKB/TrEMBL
  G5C369 ENTREZGENE, UniProtKB/TrEMBL