Lars1 (leucyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Lars1 (leucyl-tRNA synthetase 1) Heterocephalus glaber
Analyze
Symbol: Lars1 (Ensembl: LARS)
Name: leucyl-tRNA synthetase 1
RGD ID: 18934485
Description: ENCODES a protein that exhibits glutamine-tRNA ligase activity (ortholog); GTPase activator activity (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to L-leucine (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Lars; leucine--tRNA ligase, cytoplasmic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247745,609,623 - 5,673,791 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247745,609,623 - 5,673,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247745,609,623 - 5,673,791 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247745,609,623 - 5,673,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385146,113,034 - 146,182,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5146,110,566 - 146,182,696 (-)EnsemblGRCh38hg38GRCh38
GRCh375145,492,597 - 145,562,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365145,472,782 - 145,542,487 (-)NCBINCBI36Build 36hg18NCBI36
Build 345145,473,220 - 145,542,321NCBI
Celera5141,572,531 - 141,642,218 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5140,639,339 - 140,709,091 (-)NCBIHuRef
CHM1_15144,925,472 - 144,995,023 (-)NCBICHM1_1
T2T-CHM13v2.05146,647,338 - 146,718,197 (-)NCBIT2T-CHM13v2.0
Lars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391842,335,363 - 42,395,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1842,335,363 - 42,395,259 (-)EnsemblGRCm39 Ensembl
GRCm381842,202,298 - 42,262,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1842,202,298 - 42,262,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv371842,362,003 - 42,421,725 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361842,328,271 - 42,388,167 (-)NCBIMGSCv36mm8
Celera1843,563,719 - 43,623,468 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1822.37NCBI
Lars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81834,452,567 - 34,507,030 (-)NCBIGRCr8
mRatBN7.21834,201,555 - 34,256,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1834,201,549 - 34,255,931 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1834,305,753 - 34,360,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01835,024,076 - 35,078,405 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01834,400,977 - 34,455,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01836,524,013 - 36,579,471 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1836,524,007 - 36,579,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01836,191,058 - 36,244,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41835,399,197 - 35,455,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11835,434,464 - 35,491,025 (-)NCBI
Celera1833,798,541 - 33,852,822 (-)NCBICelera
Cytogenetic Map18p11NCBI
Lars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554157,923,059 - 7,983,757 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554157,923,292 - 7,983,757 (+)NCBIChiLan1.0ChiLan1.0
LARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24141,366,769 - 141,435,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15139,506,319 - 139,575,029 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05141,562,798 - 141,631,388 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15147,577,848 - 147,646,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5147,578,042 - 147,646,834 (-)Ensemblpanpan1.1panPan2
LARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1240,544,031 - 40,619,268 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl240,544,210 - 40,635,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,588,723 - 37,663,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0241,007,758 - 41,082,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl241,005,058 - 41,082,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,074,367 - 38,149,607 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,890,902 - 38,966,001 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,716,067 - 39,791,315 (-)NCBIUU_Cfam_GSD_1.0
Lars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213146,926,031 - 146,994,504 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365048,499,978 - 8,570,715 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365048,500,024 - 8,568,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2147,477,370 - 147,554,047 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12147,480,132 - 147,554,197 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22153,830,763 - 153,892,032 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12348,691,361 - 48,761,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2348,677,622 - 48,761,596 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603429,029,415 - 29,099,213 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000009776   ⟹   ENSHGLP00000009669
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247745,609,623 - 5,673,791 (-)Ensembl
RefSeq Acc Id: XM_004854345   ⟹   XP_004854402
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247745,609,912 - 5,673,815 (-)NCBI
RefSeq Acc Id: XM_021266161   ⟹   XP_021121820
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247745,609,623 - 5,673,815 (-)NCBI
RefSeq Acc Id: XM_021266162   ⟹   XP_021121821
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247745,609,911 - 5,673,815 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004854402 (Get FASTA)   NCBI Sequence Viewer  
  XP_021121820 (Get FASTA)   NCBI Sequence Viewer  
  XP_021121821 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009669
GenBank Protein JAO02656 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021121820   ⟸   XM_021266161
- Peptide Label: isoform X1
- UniProtKB: G5C840 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121821   ⟸   XM_021266162
- Peptide Label: isoform X3
- UniProtKB: G5C840 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004854402   ⟸   XM_004854345
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JEP3 (UniProtKB/TrEMBL),   G5C840 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000009669   ⟸   ENSHGLT00000009776


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006937 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009776 ENTREZGENE
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  3.90.740.10 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ia UniProtKB/TrEMBL
  Leu-tRNA-synth_Ia_arc/euk UniProtKB/TrEMBL
  M/V/L/I-tRNA-synth_anticd-bd UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNAsynth_Ia_anticodon-bd UniProtKB/TrEMBL
  Val/Leu/Ile-tRNA-synth_edit UniProtKB/TrEMBL
KEGG Report hgl:101697750 UniProtKB/TrEMBL
NCBI Gene Lars1 ENTREZGENE
PANTHER LEUCINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/TrEMBL
  PTHR45794 UniProtKB/TrEMBL
Pfam Anticodon_1 UniProtKB/TrEMBL
  tRNA-synt_1 UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF47323 UniProtKB/TrEMBL
  SSF50677 UniProtKB/TrEMBL
UniProt A0A0P6JEP3 ENTREZGENE, UniProtKB/TrEMBL
  G5C840 ENTREZGENE, UniProtKB/TrEMBL