Dkk1 (dickkopf WNT signaling pathway inhibitor 1) - Rat Genome Database

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Pathways
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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Heterocephalus glaber
Analyze
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
RGD ID: 18934342
Description: ENCODES a protein that exhibits co-receptor binding (inferred); low-density lipoprotein particle receptor binding (inferred); receptor antagonist activity (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell morphogenesis (ortholog); embryonic limb morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); Bone Fractures (ortholog); Breast Neoplasms (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Dickkopf-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,313,142 - 11,315,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical Wnt signaling pathway  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
endoderm development  (IEA,ISO)
endoderm formation  (IEA,ISO)
face morphogenesis  (IEA,ISO)
forebrain development  (IEA,ISO)
hair follicle development  (IEA,ISO)
head morphogenesis  (IEA,ISO)
heart induction  (IEA)
learning or memory  (IEA)
limb development  (IEA)
mesoderm formation  (IEA,ISO)
motor learning  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell differentiation  (IEA)
negative regulation of mesodermal cell fate specification  (IEA)
negative regulation of neuron projection development  (IEA)
negative regulation of ossification  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA)
negative regulation of presynapse assembly  (IEA)
negative regulation of SMAD protein signal transduction  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of midbrain dopaminergic neuron differentiation  (IEA)
regulation of endodermal cell fate specification  (IEA)
regulation of receptor internalization  (IEA)
regulation of synapse organization  (IEA)
regulation of synaptic transmission, glutamatergic  (IEA)
regulation of Wnt signaling pathway  (IEA,ISO)
response to retinoic acid  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)
Wnt signaling pathway involved in somitogenesis  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dkk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,313,142 - 11,315,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1052,314,281 - 52,318,042 (+)EnsemblGRCh38hg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
T2T-CHM13v2.01053,160,859 - 53,164,235 (+)NCBIT2T-CHM13v2.0
Dkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,523,276 - 30,526,896 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,523,263 - 30,527,065 (-)EnsemblGRCm39 Ensembl
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBIMGSCv36mm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.16NCBI
Dkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,794,969 - 237,798,650 (-)NCBIGRCr8
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,756,597 - 236,760,287 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,686,298 - 243,689,990 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,516,916 - 236,520,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
Dkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
DKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2864,610,223 - 64,613,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11064,615,691 - 64,619,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01048,950,704 - 48,953,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11051,084,963 - 51,088,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,084,027 - 51,089,776 (+)Ensemblpanpan1.1panPan2
DKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,697,428 - 35,701,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,697,618 - 35,701,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,582,535 - 35,586,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02637,227,528 - 37,231,046 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,228,230 - 37,231,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,133,162 - 35,136,678 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,718,578 - 34,722,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,960,801 - 35,964,325 (-)NCBIUU_Cfam_GSD_1.0
Dkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,285,796 - 75,288,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787306,941 - 310,166 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936787307,290 - 309,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,487,226 - 97,490,288 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,487,854 - 97,490,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,115,155 - 106,117,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,836,803 - 78,840,158 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,835,162 - 78,840,146 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,790,339 - 39,794,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005230   ⟹   ENSHGLP00000005163
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479111,313,142 - 11,315,982 (-)Ensembl
RefSeq Acc Id: XM_004858320   ⟹   XP_004858377
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004858377 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005163
  ENSHGLP00100001187
GenBank Protein JAO01790 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004858377   ⟸   XM_004858320
- UniProtKB: G5CAC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005163   ⟸   ENSHGLT00000005230


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003778 Ensembl, ENTREZGENE
  ENSHGLG00100000937 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000005230 ENTREZGENE
  ENSHGLT00100001222 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk1_Cys2 UniProtKB/TrEMBL
  Dkk1_N UniProtKB/TrEMBL
KEGG Report hgl:101706794 UniProtKB/TrEMBL
NCBI Gene Dkk1 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
UniProt G5CAC0 ENTREZGENE, UniProtKB/TrEMBL